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• W1999007864 abstract "To investigate possible mechanisms and association of increased oxidized Lp(a) [ox-Lp(a)] levels with presence and extent of acute coronary syndromes (ACS). Ox-Lp(a) levels were studied in 96 patients with ACS, 89 patients with stable coronary artery disease (CAD), and 100 control subjects. Compared to control, ox-Lp(a) levels increased in stable CAD patients (P < 0.001), and especially in ACS (P < 0.001) (ACS, 16.29 ± 13.80 µg/ml; stable CAD, 10.04 ± 10.32 µg/ml; control, 7.10 ± 9.16 µg/ml). The ratio of ox-Lp(a) to Lp(a) was higher in the ACS than those in the stable CAD (P < 0.05) and control (P < 0.001). Ox-Lp(a) levels were found associated with a graded increase in extent of angiographically documented CAD in the ACS (R = 0.275, P = 0.007), while not in the stable CAD (R = 0.090, P = 0.402). Multiple linear regression analysis found ox-Lp(a) (β = 0.271, P = 0.019), age (β = 0.244, P = 0.038) and TG (β = 0.213, P = 0.070) accounted for 11.1% of the variation in the extent of angiographically documented CAD in ACS patients; Lp(a) (β = 0.415, P = 0.000) and extent of CAD (β = 0.193, P = 0.071) accounted for 21.5% of that in ox-Lp(a) levels. Elevated ox-Lp(a) levels are associated with presence and severity of ACS, and may be useful for identification of patients with ACS." @default.
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• W1999007864 date "2009-10-01" @default.
• W1999007864 modified "2023-09-22" @default.
• W1999007864 title "Elevated concentrations of oxidized lipoprotein(a) are associated with the presence and severity of acute coronary syndromes" @default.
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• W1999007864 doi "https://doi.org/10.1016/j.cca.2009.07.013" @default.
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