FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999013309> ?p ?o ?g. }

• W1999013309 endingPage "781" @default.
• W1999013309 startingPage "775" @default.
• W1999013309 abstract "Cancer cells prefer to metabolize glucose through aerobic glycolysis, known as the Warburg effect. It plays a crucial role in proliferation and progression of cancer cells. However, the complete mechanism remains elusive. In recent studies, the signal transducer and activator of transcription 3 (STAT3) signaling has been discovered to have roles in cancer‑associated changes in metabolism. In this study, we find that the ginsenoside 20(S)‑Rg3, a pharmacologically active component of the traditional Chinese herb Panax ginseng, inhibits glycolysis in ovarian cancer cells by regulating hexokinase 2 (HK2) and pyruvate kinase M2 (PKM2). We also show that 20(S)‑Rg3 regulates HK2 through downregulation of p‑STAT3 (Tyr705). Furthermore, overexpression of STAT3 in ovarian cancer cells weakened the suppression of Warburg effect induced by 20(S)‑Rg3. Importantly, 20(S)‑Rg3 treatment represses HK2 expression in nude mouse xenograft models of ovarian cancer. Taken together, our results show that 20(S)‑Rg3 inhibits the Warburg effect by targeting STAT3/HK2 pathway in ovarian cancer cells, highlighting the potentiality of 20(S)‑Rg3 to be used as a therapeutic agent for ovarian cancer." @default.
• W1999013309 created "2016-06-24" @default.
• W1999013309 creator A5002375604 @default.
• W1999013309 creator A5016082098 @default.
• W1999013309 creator A5035857982 @default.
• W1999013309 creator A5064229931 @default.
• W1999013309 creator A5068252474 @default.
• W1999013309 creator A5070078107 @default.
• W1999013309 creator A5089791620 @default.
• W1999013309 date "2014-11-18" @default.
• W1999013309 modified "2023-10-01" @default.
• W1999013309 title "Ginsenoside 20(S)-Rg3 inhibits the Warburg effect through STAT3 pathways in ovarian cancer cells" @default.
• W1999013309 cites W181556572 @default.
• W1999013309 cites W1970587977 @default.
• W1999013309 cites W1981423336 @default.
• W1999013309 cites W1990090167 @default.
• W1999013309 cites W1996852003 @default.
• W1999013309 cites W2005166524 @default.
• W1999013309 cites W2007793189 @default.
• W1999013309 cites W2009062406 @default.
• W1999013309 cites W2019820921 @default.
• W1999013309 cites W2024308488 @default.
• W1999013309 cites W2030588801 @default.
• W1999013309 cites W2046401757 @default.
• W1999013309 cites W2049548558 @default.
• W1999013309 cites W2072451938 @default.
• W1999013309 cites W2074086229 @default.
• W1999013309 cites W2079990274 @default.
• W1999013309 cites W2092787533 @default.
• W1999013309 cites W2097259163 @default.
• W1999013309 cites W2101061199 @default.
• W1999013309 cites W2116201681 @default.
• W1999013309 cites W2137960344 @default.
• W1999013309 cites W2138118245 @default.
• W1999013309 cites W2138365783 @default.
• W1999013309 cites W2153524297 @default.
• W1999013309 cites W2155612395 @default.
• W1999013309 cites W2159118796 @default.
• W1999013309 cites W2161817637 @default.
• W1999013309 cites W2165316668 @default.
• W1999013309 cites W2170781836 @default.
• W1999013309 cites W4212835986 @default.
• W1999013309 doi "https://doi.org/10.3892/ijo.2014.2767" @default.
• W1999013309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25405516" @default.
• W1999013309 hasPublicationYear "2014" @default.
• W1999013309 type Work @default.
• W1999013309 sameAs 1999013309 @default.
• W1999013309 citedByCount "61" @default.
• W1999013309 countsByYear W19990133092015 @default.
• W1999013309 countsByYear W19990133092016 @default.
• W1999013309 countsByYear W19990133092017 @default.
• W1999013309 countsByYear W19990133092018 @default.
• W1999013309 countsByYear W19990133092019 @default.
• W1999013309 countsByYear W19990133092020 @default.
• W1999013309 countsByYear W19990133092021 @default.
• W1999013309 countsByYear W19990133092022 @default.
• W1999013309 countsByYear W19990133092023 @default.
• W1999013309 crossrefType "journal-article" @default.
• W1999013309 hasAuthorship W1999013309A5002375604 @default.
• W1999013309 hasAuthorship W1999013309A5016082098 @default.
• W1999013309 hasAuthorship W1999013309A5035857982 @default.
• W1999013309 hasAuthorship W1999013309A5064229931 @default.
• W1999013309 hasAuthorship W1999013309A5068252474 @default.
• W1999013309 hasAuthorship W1999013309A5070078107 @default.
• W1999013309 hasAuthorship W1999013309A5089791620 @default.
• W1999013309 hasBestOaLocation W19990133091 @default.
• W1999013309 hasConcept C10730799 @default.
• W1999013309 hasConcept C109156525 @default.
• W1999013309 hasConcept C121608353 @default.
• W1999013309 hasConcept C171958077 @default.
• W1999013309 hasConcept C181199279 @default.
• W1999013309 hasConcept C20251656 @default.
• W1999013309 hasConcept C2778923194 @default.
• W1999013309 hasConcept C2779826832 @default.
• W1999013309 hasConcept C2780427987 @default.
• W1999013309 hasConcept C2780854706 @default.
• W1999013309 hasConcept C2781018059 @default.
• W1999013309 hasConcept C29537977 @default.
• W1999013309 hasConcept C502942594 @default.
• W1999013309 hasConcept C54355233 @default.
• W1999013309 hasConcept C55493867 @default.
• W1999013309 hasConcept C55885012 @default.
• W1999013309 hasConcept C62478195 @default.
• W1999013309 hasConcept C86803240 @default.
• W1999013309 hasConcept C95444343 @default.
• W1999013309 hasConcept C96232424 @default.
• W1999013309 hasConceptScore W1999013309C10730799 @default.
• W1999013309 hasConceptScore W1999013309C109156525 @default.
• W1999013309 hasConceptScore W1999013309C121608353 @default.
• W1999013309 hasConceptScore W1999013309C171958077 @default.
• W1999013309 hasConceptScore W1999013309C181199279 @default.
• W1999013309 hasConceptScore W1999013309C20251656 @default.
• W1999013309 hasConceptScore W1999013309C2778923194 @default.
• W1999013309 hasConceptScore W1999013309C2779826832 @default.
• W1999013309 hasConceptScore W1999013309C2780427987 @default.
• W1999013309 hasConceptScore W1999013309C2780854706 @default.
• W1999013309 hasConceptScore W1999013309C2781018059 @default.
• W1999013309 hasConceptScore W1999013309C29537977 @default.

• next