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• W1999023373 abstract "The reaction of [(H2O)(NH3)5RuII]2+ with bleomycin forms at least two stable products following oxidation to the Ru(III) analog. Spectroscopic and electrochemical measurements indicate monodentate binding of [(NH3)5RuIII] to the imidazole and pyrimidine moieties, with coordination to the latter involving the exocyclic amine nitrogen. DNA cleavage studies show the complexes to be ineffective in DNA strand scission. In vitro biological studies reveal these adducts to be cytotoxic." @default.
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• W1999023373 date "1986-01-01" @default.
• W1999023373 modified "2023-09-26" @default.
• W1999023373 title "Chemical and biological properties of pentaammineruthenium-bleomycin complexes" @default.
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• W1999023373 doi "https://doi.org/10.1016/s0009-2797(86)80069-2" @default.
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