FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999033072> ?p ?o ?g. }

• W1999033072 endingPage "149" @default.
• W1999033072 startingPage "143" @default.
• W1999033072 abstract "Trichomonas vaginalis, a parasitic protozoan and the causative agent of trichomoniasis, lacks de novo purine nucleotide synthesis and possesses a unique purine salvage pathway, consisting of a bacterial type purine nucleoside phosphorylase and a purine nucleoside kinase. It is generally believed that adenine and guanine are converted to their corresponding nucleosides and then further phosphorylated to form AMP and GMP, respectively, as the main as well as the essential pathway of replenishing the purine nucleotide pool in the organism. Formycin A, an analogue of adenosine, inhibits both enzymes as well as the in vitro growth of T. vaginalis with an estimated IC50 of 0.27 μM. This growth inhibition was reversed by adding adenine to the culture medium but not by adding guanine or hypoxanthine. Furthermore, T. vaginalis can grow in semi-defined medium supplemented with only adenine but not with guanine or hypoxanthine. Radiolabeling experiments followed by HPLC analysis of the purine nucleotide pool in T. vaginalis demonstrated incorporation of [8-14C]adenine into both adenine and guanine nucleotides, whereas [8-14C]guanine was incorporated only into guanine nucleotides. Substantial adenosine deaminase activity and significant IMP dehydrogenase and GMP synthetase activities were identified in T. vaginalis lysate, suggesting a pathway capable of converting adenine to GMP via adenosine. This purine salvage scheme depicts adenosine the primary precursor of the entire purine nucleotide pool in T. vaginalis and the purine nucleoside kinase one of the most pivotal enzymes in purine salvage and a potential target for anti-trichomoniasis chemotherapy." @default.
• W1999033072 created "2016-06-24" @default.
• W1999033072 creator A5013340169 @default.
• W1999033072 creator A5090487503 @default.
• W1999033072 date "2003-04-01" @default.
• W1999033072 modified "2023-10-14" @default.
• W1999033072 title "Adenosine is the primary precursor of all purine nucleotides in Trichomonas vaginalis" @default.
• W1999033072 cites W1014017984 @default.
• W1999033072 cites W1564988623 @default.
• W1999033072 cites W1687051724 @default.
• W1999033072 cites W1980034957 @default.
• W1999033072 cites W1982524397 @default.
• W1999033072 cites W1985292832 @default.
• W1999033072 cites W1987354667 @default.
• W1999033072 cites W1992771067 @default.
• W1999033072 cites W1994039834 @default.
• W1999033072 cites W1999427682 @default.
• W1999033072 cites W1999966576 @default.
• W1999033072 cites W2000425642 @default.
• W1999033072 cites W2002002015 @default.
• W1999033072 cites W2006732267 @default.
• W1999033072 cites W2009868920 @default.
• W1999033072 cites W2011558271 @default.
• W1999033072 cites W2011584599 @default.
• W1999033072 cites W2033746571 @default.
• W1999033072 cites W2041735993 @default.
• W1999033072 cites W2051992969 @default.
• W1999033072 cites W2069841722 @default.
• W1999033072 cites W2070953605 @default.
• W1999033072 cites W2074962159 @default.
• W1999033072 cites W2075487159 @default.
• W1999033072 cites W2075541528 @default.
• W1999033072 cites W2091908982 @default.
• W1999033072 cites W2122459084 @default.
• W1999033072 cites W2144550154 @default.
• W1999033072 cites W2164702049 @default.
• W1999033072 cites W4214926555 @default.
• W1999033072 doi "https://doi.org/10.1016/s0166-6851(02)00330-4" @default.
• W1999033072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12672523" @default.
• W1999033072 hasPublicationYear "2003" @default.
• W1999033072 type Work @default.
• W1999033072 sameAs 1999033072 @default.
• W1999033072 citedByCount "37" @default.
• W1999033072 countsByYear W19990330722012 @default.
• W1999033072 countsByYear W19990330722015 @default.
• W1999033072 countsByYear W19990330722016 @default.
• W1999033072 countsByYear W19990330722017 @default.
• W1999033072 countsByYear W19990330722018 @default.
• W1999033072 countsByYear W19990330722019 @default.
• W1999033072 countsByYear W19990330722020 @default.
• W1999033072 countsByYear W19990330722021 @default.
• W1999033072 countsByYear W19990330722023 @default.
• W1999033072 crossrefType "journal-article" @default.
• W1999033072 hasAuthorship W1999033072A5013340169 @default.
• W1999033072 hasAuthorship W1999033072A5090487503 @default.
• W1999033072 hasConcept C104317684 @default.
• W1999033072 hasConcept C153911025 @default.
• W1999033072 hasConcept C181199279 @default.
• W1999033072 hasConcept C194101687 @default.
• W1999033072 hasConcept C2776476023 @default.
• W1999033072 hasConcept C2776991684 @default.
• W1999033072 hasConcept C2778301229 @default.
• W1999033072 hasConcept C2781116151 @default.
• W1999033072 hasConcept C34628245 @default.
• W1999033072 hasConcept C512185932 @default.
• W1999033072 hasConcept C55493867 @default.
• W1999033072 hasConcept C71615608 @default.
• W1999033072 hasConcept C86803240 @default.
• W1999033072 hasConceptScore W1999033072C104317684 @default.
• W1999033072 hasConceptScore W1999033072C153911025 @default.
• W1999033072 hasConceptScore W1999033072C181199279 @default.
• W1999033072 hasConceptScore W1999033072C194101687 @default.
• W1999033072 hasConceptScore W1999033072C2776476023 @default.
• W1999033072 hasConceptScore W1999033072C2776991684 @default.
• W1999033072 hasConceptScore W1999033072C2778301229 @default.
• W1999033072 hasConceptScore W1999033072C2781116151 @default.
• W1999033072 hasConceptScore W1999033072C34628245 @default.
• W1999033072 hasConceptScore W1999033072C512185932 @default.
• W1999033072 hasConceptScore W1999033072C55493867 @default.
• W1999033072 hasConceptScore W1999033072C71615608 @default.
• W1999033072 hasConceptScore W1999033072C86803240 @default.
• W1999033072 hasIssue "2" @default.
• W1999033072 hasLocation W19990330721 @default.
• W1999033072 hasLocation W19990330722 @default.
• W1999033072 hasOpenAccess W1999033072 @default.
• W1999033072 hasPrimaryLocation W19990330721 @default.
• W1999033072 hasRelatedWork W1504841080 @default.
• W1999033072 hasRelatedWork W1985654998 @default.
• W1999033072 hasRelatedWork W2000723263 @default.
• W1999033072 hasRelatedWork W2016119250 @default.
• W1999033072 hasRelatedWork W2049601230 @default.
• W1999033072 hasRelatedWork W2079469928 @default.
• W1999033072 hasRelatedWork W2086038894 @default.
• W1999033072 hasRelatedWork W2159710370 @default.
• W1999033072 hasRelatedWork W2413534244 @default.
• W1999033072 hasRelatedWork W54361237 @default.
• W1999033072 hasVolume "127" @default.
• W1999033072 isParatext "false" @default.

• next