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• W1999036268 abstract "To determine if corticotroph nonsuppression, as reflected by beta-endorphin nonsuppression, occurs before cortisol nonsuppression (defined as a cortisol level of > 140 nmol/L) when examining multiple time points in a day.The General Medical Clinical Research Center and Inpatient Depression Research Unit, Ann Arbor, Mich.Multiple blood samples were obtained through an intravenous catheter around the time points of 8 AM, noon, and 4 PM and assayed for beta-endorphin and cortisol.Patients meeting Research Diagnostic Criteria for the diagnosis of major depressive disorder, primary and simple. A total of 73 subjects, both inpatients and outpatients, were studied.Samples were obtained both at baseline and 1 day after administration of 1 mg of dexamethasone at 11:30 PM.Overall 39 patients (53%) demonstrated beta-endorphin nonsuppression after administration of dexamethasone at any of the three time points, while only eight patients (11%) demonstrated cortisol nonsuppression at any of these time points. Cortisol nonsuppression, but not beta-endorphin nonsuppression, was associated with lower concentrations of dexamethasone in plasma. Baseline cortisol and menopausal status were significantly associated with beta-endorphin nonsuppression in women." @default.
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• W1999036268 date "1993-05-01" @default.
• W1999036268 modified "2023-09-24" @default.
• W1999036268 title "Dissociation Between Pituitary and Adrenal Suppression to Dexamethasone in Depression" @default.
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• W1999036268 doi "https://doi.org/10.1001/archpsyc.1993.01820170073010" @default.
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