FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999050465> ?p ?o ?g. }

• W1999050465 endingPage "906" @default.
• W1999050465 startingPage "898" @default.
• W1999050465 abstract "Silibinin, a flavonolignan from milk thistle seeds, possesses cancer chemopreventive properties in rodent models of carcinogenesis. We tested the hypotheses that silibinin or silipide, silibinin formulated with phospholipids, delays tumour development in TRAMP or Apc(Min) mice, genetic models of prostate or intestinal malignancies, respectively. Mice received silibinin or silipide with their diet (0.2% silibinin equivalents) from weaning. Intervention with silipide reduced the size of well differentiated TRAMP adenocarcinomas by 31%. Silipide and silibinin decreased the incidence of poorly differentiated carcinomas by 61% compared to mice on control diet. Silipide decreased plasma levels of insulin-like growth factor (IGF)-1 by 36%. Levels of circulating IGF binding protein (IGFBP)-3 in mice on silipide or silibinin were 3.9- or 5.9-fold, respectively, elevated over those in control TRAMP mice. In Apc(Min) mice silibinin, but not silipide, had only a marginal adenoma number-reducing effect. The results cautiously support the advancement of silipide to the stage of clinical investigation in prostate cancer." @default.
• W1999050465 created "2016-06-24" @default.
• W1999050465 creator A5035716657 @default.
• W1999050465 creator A5053371660 @default.
• W1999050465 creator A5055907524 @default.
• W1999050465 creator A5058052872 @default.
• W1999050465 creator A5073989904 @default.
• W1999050465 creator A5087576978 @default.
• W1999050465 creator A5090645051 @default.
• W1999050465 date "2008-04-01" @default.
• W1999050465 modified "2023-10-14" @default.
• W1999050465 title "Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels" @default.
• W1999050465 cites W1574172480 @default.
• W1999050465 cites W1972486056 @default.
• W1999050465 cites W1974917142 @default.
• W1999050465 cites W1974967245 @default.
• W1999050465 cites W1988959205 @default.
• W1999050465 cites W1993855694 @default.
• W1999050465 cites W2002412557 @default.
• W1999050465 cites W2005508694 @default.
• W1999050465 cites W2010057554 @default.
• W1999050465 cites W2019809922 @default.
• W1999050465 cites W2033032904 @default.
• W1999050465 cites W2039299190 @default.
• W1999050465 cites W2044826176 @default.
• W1999050465 cites W2074954985 @default.
• W1999050465 cites W2080835467 @default.
• W1999050465 cites W2084450801 @default.
• W1999050465 cites W2098419763 @default.
• W1999050465 cites W2099054500 @default.
• W1999050465 cites W2105271234 @default.
• W1999050465 cites W2109596707 @default.
• W1999050465 cites W2119122462 @default.
• W1999050465 cites W2125894780 @default.
• W1999050465 cites W2131080175 @default.
• W1999050465 cites W2131257484 @default.
• W1999050465 cites W2142285790 @default.
• W1999050465 cites W2144111899 @default.
• W1999050465 cites W2148083325 @default.
• W1999050465 cites W2170275689 @default.
• W1999050465 cites W2171943253 @default.
• W1999050465 cites W2315175787 @default.
• W1999050465 cites W2396478796 @default.
• W1999050465 cites W2479044294 @default.
• W1999050465 doi "https://doi.org/10.1016/j.ejca.2008.02.020" @default.
• W1999050465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18343654" @default.
• W1999050465 hasPublicationYear "2008" @default.
• W1999050465 type Work @default.
• W1999050465 sameAs 1999050465 @default.
• W1999050465 citedByCount "38" @default.
• W1999050465 countsByYear W19990504652012 @default.
• W1999050465 countsByYear W19990504652013 @default.
• W1999050465 countsByYear W19990504652014 @default.
• W1999050465 countsByYear W19990504652015 @default.
• W1999050465 countsByYear W19990504652016 @default.
• W1999050465 countsByYear W19990504652017 @default.
• W1999050465 countsByYear W19990504652019 @default.
• W1999050465 countsByYear W19990504652020 @default.
• W1999050465 countsByYear W19990504652021 @default.
• W1999050465 countsByYear W19990504652022 @default.
• W1999050465 countsByYear W19990504652023 @default.
• W1999050465 crossrefType "journal-article" @default.
• W1999050465 hasAuthorship W1999050465A5035716657 @default.
• W1999050465 hasAuthorship W1999050465A5053371660 @default.
• W1999050465 hasAuthorship W1999050465A5055907524 @default.
• W1999050465 hasAuthorship W1999050465A5058052872 @default.
• W1999050465 hasAuthorship W1999050465A5073989904 @default.
• W1999050465 hasAuthorship W1999050465A5087576978 @default.
• W1999050465 hasAuthorship W1999050465A5090645051 @default.
• W1999050465 hasConcept C121608353 @default.
• W1999050465 hasConcept C126322002 @default.
• W1999050465 hasConcept C134018914 @default.
• W1999050465 hasConcept C2777130413 @default.
• W1999050465 hasConcept C2780192828 @default.
• W1999050465 hasConcept C2780940892 @default.
• W1999050465 hasConcept C502942594 @default.
• W1999050465 hasConcept C555283112 @default.
• W1999050465 hasConcept C71924100 @default.
• W1999050465 hasConcept C86803240 @default.
• W1999050465 hasConceptScore W1999050465C121608353 @default.
• W1999050465 hasConceptScore W1999050465C126322002 @default.
• W1999050465 hasConceptScore W1999050465C134018914 @default.
• W1999050465 hasConceptScore W1999050465C2777130413 @default.
• W1999050465 hasConceptScore W1999050465C2780192828 @default.
• W1999050465 hasConceptScore W1999050465C2780940892 @default.
• W1999050465 hasConceptScore W1999050465C502942594 @default.
• W1999050465 hasConceptScore W1999050465C555283112 @default.
• W1999050465 hasConceptScore W1999050465C71924100 @default.
• W1999050465 hasConceptScore W1999050465C86803240 @default.
• W1999050465 hasIssue "6" @default.
• W1999050465 hasLocation W19990504651 @default.
• W1999050465 hasLocation W19990504652 @default.
• W1999050465 hasOpenAccess W1999050465 @default.
• W1999050465 hasPrimaryLocation W19990504651 @default.
• W1999050465 hasRelatedWork W1499339123 @default.
• W1999050465 hasRelatedWork W2117059884 @default.
• W1999050465 hasRelatedWork W2595647585 @default.
• W1999050465 hasRelatedWork W2708327784 @default.

• next