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• W1999054014 endingPage "1002" @default.
• W1999054014 startingPage "996" @default.
• W1999054014 abstract "Telomere length shortens with age and predicts the onset of replicative senescence. Recently, short telomeres have been linked to the etiology of degenerative diseases such as idiopathic pulmonary fibrosis, bone marrow failure, and cryptogenic liver cirrhosis. These disorders have recognizable clinical manifestations, and the telomere defect explains their genetics and informs the approach to their treatment. Here, I review how telomere biology has become intimately connected to clinical paradigms both for understanding pathophysiology and for individualizing therapy decisions. I also critically examine nuances of interpreting telomere length measurement in clinical studies." @default.
• W1999054014 created "2016-06-24" @default.
• W1999054014 creator A5023060225 @default.
• W1999054014 date "2013-03-01" @default.
• W1999054014 modified "2023-10-13" @default.
• W1999054014 title "Telomeres and age-related disease: how telomere biology informs clinical paradigms" @default.
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• W1999054014 doi "https://doi.org/10.1172/jci66370" @default.
• W1999054014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3673231" @default.
• W1999054014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23454763" @default.
• W1999054014 hasPublicationYear "2013" @default.
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