FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999056362> ?p ?o ?g. }

• W1999056362 endingPage "168" @default.
• W1999056362 startingPage "160" @default.
• W1999056362 abstract "Available studies indicate that the adrenergic stimulation of pineal cyclic GMP production involves stimulation of guanylyl cyclase activity by nitric oxide (NO) derived from arginine. This line of investigation was extended in the present study. Using a highly sensitive microassay, it was found that pineal NO synthase activity is present at levels approximately 30% of those in the cerebellum, that approximately 95% of enzyme activity is cytoplasmic, that the enzyme is Ca2+/calmodulin-dependent and that enzyme activity is inhibited by the arginine analog NG-nitro-L-arginine methyl ester (L-NAME). Norepinephrine treatment of intact glands in culture increased [3H]citrulline formation from [3H]arginine. This treatment also increased the formation of an NO-like compound, indicating that NO synthase activity in the intact gland is elevated by adrenergic stimulation. Studies on the effects of inhibition of NO synthase activity indicated that treatments known to inhibit NO synthase activity and the adrenergic stimulation of cyclic GMP accumulation did not inhibit adrenergic stimulation of pineal cyclic AMP, N-acetyltransferase activity or melatonin production. These observations support the hypothesis that NE stimulation of pineal cyclic GMP accumulation involves stimulation of a Ca2+/calmodulin-sensitive form of NO synthase, resulting in enhanced accumulation of NO; and, that although NO appears to play a role in the adrenergic stimulation of pineal cyclic GMP accumulation, it does not appear to play a critical role in the adrenergic stimulation of cyclic AMP, N-acetyltransferase activity or melatonin production." @default.
• W1999056362 created "2016-06-24" @default.
• W1999056362 creator A5068515709 @default.
• W1999056362 creator A5070313847 @default.
• W1999056362 creator A5073549812 @default.
• W1999056362 creator A5077150324 @default.
• W1999056362 creator A5086526301 @default.
• W1999056362 date "1994-07-01" @default.
• W1999056362 modified "2023-09-23" @default.
• W1999056362 title "Pineal nitric oxide synthase: characteristics, adrenergic regulation and function" @default.
• W1999056362 cites W1502454614 @default.
• W1999056362 cites W1523578031 @default.
• W1999056362 cites W1555929637 @default.
• W1999056362 cites W1580622719 @default.
• W1999056362 cites W1587748294 @default.
• W1999056362 cites W1602807836 @default.
• W1999056362 cites W1668450698 @default.
• W1999056362 cites W1972616722 @default.
• W1999056362 cites W1999445464 @default.
• W1999056362 cites W2007837102 @default.
• W1999056362 cites W2010136459 @default.
• W1999056362 cites W2013122899 @default.
• W1999056362 cites W2019814232 @default.
• W1999056362 cites W2037392995 @default.
• W1999056362 cites W2042795327 @default.
• W1999056362 cites W2043385214 @default.
• W1999056362 cites W2043561221 @default.
• W1999056362 cites W2061382541 @default.
• W1999056362 cites W2061590032 @default.
• W1999056362 cites W2077061468 @default.
• W1999056362 cites W2082350804 @default.
• W1999056362 cites W2091622880 @default.
• W1999056362 cites W2119781983 @default.
• W1999056362 cites W2145828216 @default.
• W1999056362 cites W2154860936 @default.
• W1999056362 cites W2164522979 @default.
• W1999056362 cites W2201852740 @default.
• W1999056362 cites W2338001129 @default.
• W1999056362 cites W4293247451 @default.
• W1999056362 cites W2083761359 @default.
• W1999056362 doi "https://doi.org/10.1016/0006-8993(94)90693-9" @default.
• W1999056362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7522930" @default.
• W1999056362 hasPublicationYear "1994" @default.
• W1999056362 type Work @default.
• W1999056362 sameAs 1999056362 @default.
• W1999056362 citedByCount "39" @default.
• W1999056362 countsByYear W19990563622014 @default.
• W1999056362 countsByYear W19990563622015 @default.
• W1999056362 crossrefType "journal-article" @default.
• W1999056362 hasAuthorship W1999056362A5068515709 @default.
• W1999056362 hasAuthorship W1999056362A5070313847 @default.
• W1999056362 hasAuthorship W1999056362A5073549812 @default.
• W1999056362 hasAuthorship W1999056362A5077150324 @default.
• W1999056362 hasAuthorship W1999056362A5086526301 @default.
• W1999056362 hasConcept C112243037 @default.
• W1999056362 hasConcept C126322002 @default.
• W1999056362 hasConcept C134018914 @default.
• W1999056362 hasConcept C158453852 @default.
• W1999056362 hasConcept C170493617 @default.
• W1999056362 hasConcept C181199279 @default.
• W1999056362 hasConcept C185592680 @default.
• W1999056362 hasConcept C202023056 @default.
• W1999056362 hasConcept C24998067 @default.
• W1999056362 hasConcept C2777468819 @default.
• W1999056362 hasConcept C2777622882 @default.
• W1999056362 hasConcept C2778182776 @default.
• W1999056362 hasConcept C2780059843 @default.
• W1999056362 hasConcept C29688787 @default.
• W1999056362 hasConcept C515207424 @default.
• W1999056362 hasConcept C519581460 @default.
• W1999056362 hasConcept C55493867 @default.
• W1999056362 hasConcept C71924100 @default.
• W1999056362 hasConcept C86803240 @default.
• W1999056362 hasConceptScore W1999056362C112243037 @default.
• W1999056362 hasConceptScore W1999056362C126322002 @default.
• W1999056362 hasConceptScore W1999056362C134018914 @default.
• W1999056362 hasConceptScore W1999056362C158453852 @default.
• W1999056362 hasConceptScore W1999056362C170493617 @default.
• W1999056362 hasConceptScore W1999056362C181199279 @default.
• W1999056362 hasConceptScore W1999056362C185592680 @default.
• W1999056362 hasConceptScore W1999056362C202023056 @default.
• W1999056362 hasConceptScore W1999056362C24998067 @default.
• W1999056362 hasConceptScore W1999056362C2777468819 @default.
• W1999056362 hasConceptScore W1999056362C2777622882 @default.
• W1999056362 hasConceptScore W1999056362C2778182776 @default.
• W1999056362 hasConceptScore W1999056362C2780059843 @default.
• W1999056362 hasConceptScore W1999056362C29688787 @default.
• W1999056362 hasConceptScore W1999056362C515207424 @default.
• W1999056362 hasConceptScore W1999056362C519581460 @default.
• W1999056362 hasConceptScore W1999056362C55493867 @default.
• W1999056362 hasConceptScore W1999056362C71924100 @default.
• W1999056362 hasConceptScore W1999056362C86803240 @default.
• W1999056362 hasIssue "1-2" @default.
• W1999056362 hasLocation W19990563621 @default.
• W1999056362 hasLocation W19990563622 @default.
• W1999056362 hasOpenAccess W1999056362 @default.
• W1999056362 hasPrimaryLocation W19990563621 @default.
• W1999056362 hasRelatedWork W1189948319 @default.

• next