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• W1999058908 endingPage "e1002730" @default.
• W1999058908 startingPage "e1002730" @default.
• W1999058908 abstract "Chromosome pairing in meiotic prophase is a prerequisite for the high fidelity of chromosome segregation that haploidizes the genome prior to gamete formation. In the budding yeast Saccharomyces cerevisiae, as in most multicellular eukaryotes, homologous pairing at the cytological level reflects the contemporaneous search for homology at the molecular level, where DNA double-strand broken ends find and interact with templates for repair on homologous chromosomes. Synapsis (synaptonemal complex formation) stabilizes pairing and supports DNA repair. The bouquet stage, where telomeres have formed a transient single cluster early in meiotic prophase, and telomere-promoted rapid meiotic prophase chromosome movements (RPMs) are prominent temporal correlates of pairing and synapsis. The bouquet has long been thought to contribute to the kinetics of pairing, but the individual roles of bouquet and RPMs are difficult to assess because of common dependencies. For example, in budding yeast RPMs and bouquet both require the broadly conserved SUN protein Mps3 as well as Ndj1 and Csm4, which link telomeres to the cytoskeleton through the intact nuclear envelope. We find that mutants in these genes provide a graded series of RPM activity: wild-type>mps3-dCC>mps3-dAR>ndj1Δ>mps3-dNT = csm4Δ. Pairing rates are directly correlated with RPM activity even though only wild-type forms a bouquet, suggesting that RPMs promote homologous pairing directly while the bouquet plays at most a minor role in Saccharomyces cerevisiae. A new collision trap assay demonstrates that RPMs generate homologous and heterologous chromosome collisions in or before the earliest stages of prophase, suggesting that RPMs contribute to pairing by stirring the nuclear contents to aid the recombination-mediated homology search." @default.
• W1999058908 created "2016-06-24" @default.
• W1999058908 creator A5003578767 @default.
• W1999058908 creator A5014953970 @default.
• W1999058908 creator A5077261619 @default.
• W1999058908 date "2012-05-24" @default.
• W1999058908 modified "2023-09-27" @default.
• W1999058908 title "Meiotic Chromosome Pairing Is Promoted by Telomere-Led Chromosome Movements Independent of Bouquet Formation" @default.
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• W1999058908 doi "https://doi.org/10.1371/journal.pgen.1002730" @default.
• W1999058908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3359977" @default.
• W1999058908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22654677" @default.
• W1999058908 hasPublicationYear "2012" @default.
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