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• W1999063564 abstract "Several experimental studies have shown that acidosis impairs neurotransmitter uptake processes. The purpose of this study was to determine the mechanism underlying acidosis-induced alterations of the high-affinity dopamine (DA) uptake in rat striatal synaptosomes and slices. Acidosis (pH 5.5) performed either by lactic acid or phosphoric acid induced a decrease in the high-affinity DA uptake in the two striatal models, slices being lesser affected than synaptosomes. Addition of the acid prior to uptake measurement led to a strong reduction of the DA uptake velocity. This early inhibitory effect was completely reversed when acid was removed from the medium by washings. Conversely, when slices and synaptosomes were pre-incubated for different times with each acid, DA uptake remained inhibited in spite of washings. This later inhibition was accompanied by the production of thiobarbituric acid reactive substances, a marker of lipid peroxidation, and was partially prevented by the antioxidant Trolox. Taken together, these results suggest that acidosis, in a degree encountered during ischemia, alters the high-affinity DA uptake by at least two ways: an early and direct effect of H+ ions on the DA transporters, and subsequently an inhibition partially mediated by free radical damage." @default.
• W1999063564 created "2016-06-24" @default.
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• W1999063564 date "2003-01-01" @default.
• W1999063564 modified "2023-09-25" @default.
• W1999063564 title "Evidence that acidosis alters the high-affinity dopamine uptake in rat striatal slices and synaptosomes by different mechanisms partially related to oxidative damage" @default.
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• W1999063564 doi "https://doi.org/10.1016/s0197-0186(02)00061-x" @default.
• W1999063564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12441165" @default.
• W1999063564 hasPublicationYear "2003" @default.
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