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- W1999064908 abstract "Expression of Kaposi's sarcoma-associated herpesvirus v-FLIP leads to the spindle-shape morphology of endothelial cells and is essential for the survival of primary effusion lymphoma cells. Activation of the NF-κB transcription factor by v-FLIP is responsible for these effects. Considering that the interferon-β (ifn-β) gene is regulated partly through NF-κB, we sought to determine whether v-FLIP would activate the expression of the ifn-β gene. Our results indicate that when v-FLIP is expressed by itself it has no effect on ifn-β gene activation but when it is combined with known IFN-β inducers, a synergistic activation of the ifn-β gene occurs. This effect is strictly dependent on NF-κB and is mediated through the positive regulatory domain II of the IFN-β promoter. Furthermore, we report that protection from Fas-induced cell-death by v-FLIP is observed whether or not the type I IFN signaling pathway is activated. Our work therefore contributes to increase our knowledge on v-FLIP, highlighting the complex immunomodulatory properties of this anti-apoptotic viral protein." @default.
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- W1999064908 date "2007-10-01" @default.
- W1999064908 modified "2023-10-16" @default.
- W1999064908 title "Synergistic activation of interferon-β gene transcription by the viral FLICE inhibitory protein of Kaposi's sarcoma-associated herpesvirus and type I IFN activators" @default.
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- W1999064908 doi "https://doi.org/10.1002/eji.200737181" @default.
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