FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999072783> ?p ?o ?g. }

• W1999072783 endingPage "3585" @default.
• W1999072783 startingPage "3579" @default.
• W1999072783 abstract "Treatment of bacteriophage MS2 with 4'-(hydroxymethyl)-4,5',8-trimethylpsoralen and 360-nm light caused a dose-dependent decline in the infectivity of the virus. Covalent photobinding of a single psoralen molecule on the phage genome was a lethal event. Ribonucleic acid (RNA) extracted from psoralen and light-treated virus had a dose-dependent 385-nm fluorescence emission but was unaltered in its physical properties compared to control RNA samples. Phage adsorption and penetration in Escherichia coli host cells were unaffected, but in vivo replication of the treated virus was affected to the same extent as infectivity. The cell-free translational activity of the MS2 RNA was also severely reduced after psoralen and light treatment of the phage. Examination of the in vitro translation products revealed that the synthesis of the viral replicase protein was most substantially affected. Psoralen treatment of purified, protein-free MS2 RNA promoted an even greater reduction in cell-free synthesis of all viral proteins. This difference in translational function was consistent with the observation that virion-free RNA bound approximately 4 times as much psoralen as did RNA treated within the phage capsid. It was concluded that the replicase gene is the most sensitive region of the viral RNA molecule for psoralen binding." @default.
• W1999072783 created "2016-06-24" @default.
• W1999072783 creator A5056024477 @default.
• W1999072783 creator A5089855178 @default.
• W1999072783 date "1981-06-09" @default.
• W1999072783 modified "2023-09-26" @default.
• W1999072783 title "Effects of (hydroxymethyl)trimethylpsoralen on structure and function of bacteriophage MS2 ribonucleic acid" @default.
• W1999072783 cites W1484498918 @default.
• W1999072783 cites W1513237425 @default.
• W1999072783 cites W1530036925 @default.
• W1999072783 cites W1586147123 @default.
• W1999072783 cites W1755988619 @default.
• W1999072783 cites W1963589513 @default.
• W1999072783 cites W1965556993 @default.
• W1999072783 cites W1970235943 @default.
• W1999072783 cites W1973738093 @default.
• W1999072783 cites W1982765951 @default.
• W1999072783 cites W1984013243 @default.
• W1999072783 cites W2000641090 @default.
• W1999072783 cites W2005391395 @default.
• W1999072783 cites W2007576361 @default.
• W1999072783 cites W2012136538 @default.
• W1999072783 cites W2013370121 @default.
• W1999072783 cites W2021417532 @default.
• W1999072783 cites W2032652449 @default.
• W1999072783 cites W2034277598 @default.
• W1999072783 cites W2035686904 @default.
• W1999072783 cites W2044785588 @default.
• W1999072783 cites W2060932537 @default.
• W1999072783 cites W2063262141 @default.
• W1999072783 cites W2068567113 @default.
• W1999072783 cites W2070688330 @default.
• W1999072783 cites W2073597280 @default.
• W1999072783 cites W2077594845 @default.
• W1999072783 cites W2094664738 @default.
• W1999072783 cites W2101397589 @default.
• W1999072783 cites W2119204081 @default.
• W1999072783 cites W2144202537 @default.
• W1999072783 cites W2147807642 @default.
• W1999072783 cites W2205516038 @default.
• W1999072783 cites W2225804084 @default.
• W1999072783 doi "https://doi.org/10.1021/bi00515a042" @default.
• W1999072783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7020756" @default.
• W1999072783 hasPublicationYear "1981" @default.
• W1999072783 type Work @default.
• W1999072783 sameAs 1999072783 @default.
• W1999072783 citedByCount "5" @default.
• W1999072783 crossrefType "journal-article" @default.
• W1999072783 hasAuthorship W1999072783A5056024477 @default.
• W1999072783 hasAuthorship W1999072783A5089855178 @default.
• W1999072783 hasConcept C104317684 @default.
• W1999072783 hasConcept C106358424 @default.
• W1999072783 hasConcept C153911025 @default.
• W1999072783 hasConcept C159047783 @default.
• W1999072783 hasConcept C185592680 @default.
• W1999072783 hasConcept C202878990 @default.
• W1999072783 hasConcept C2522874641 @default.
• W1999072783 hasConcept C2775940340 @default.
• W1999072783 hasConcept C2776441376 @default.
• W1999072783 hasConcept C2776449523 @default.
• W1999072783 hasConcept C2781110370 @default.
• W1999072783 hasConcept C41258723 @default.
• W1999072783 hasConcept C547475151 @default.
• W1999072783 hasConcept C552990157 @default.
• W1999072783 hasConcept C55493867 @default.
• W1999072783 hasConcept C67705224 @default.
• W1999072783 hasConcept C86803240 @default.
• W1999072783 hasConceptScore W1999072783C104317684 @default.
• W1999072783 hasConceptScore W1999072783C106358424 @default.
• W1999072783 hasConceptScore W1999072783C153911025 @default.
• W1999072783 hasConceptScore W1999072783C159047783 @default.
• W1999072783 hasConceptScore W1999072783C185592680 @default.
• W1999072783 hasConceptScore W1999072783C202878990 @default.
• W1999072783 hasConceptScore W1999072783C2522874641 @default.
• W1999072783 hasConceptScore W1999072783C2775940340 @default.
• W1999072783 hasConceptScore W1999072783C2776441376 @default.
• W1999072783 hasConceptScore W1999072783C2776449523 @default.
• W1999072783 hasConceptScore W1999072783C2781110370 @default.
• W1999072783 hasConceptScore W1999072783C41258723 @default.
• W1999072783 hasConceptScore W1999072783C547475151 @default.
• W1999072783 hasConceptScore W1999072783C552990157 @default.
• W1999072783 hasConceptScore W1999072783C55493867 @default.
• W1999072783 hasConceptScore W1999072783C67705224 @default.
• W1999072783 hasConceptScore W1999072783C86803240 @default.
• W1999072783 hasIssue "12" @default.
• W1999072783 hasLocation W19990727831 @default.
• W1999072783 hasLocation W19990727832 @default.
• W1999072783 hasOpenAccess W1999072783 @default.
• W1999072783 hasPrimaryLocation W19990727831 @default.
• W1999072783 hasRelatedWork W1547704451 @default.
• W1999072783 hasRelatedWork W1992301543 @default.
• W1999072783 hasRelatedWork W1999072783 @default.
• W1999072783 hasRelatedWork W2083930860 @default.
• W1999072783 hasRelatedWork W2102914026 @default.
• W1999072783 hasRelatedWork W2397272805 @default.
• W1999072783 hasRelatedWork W2598474077 @default.
• W1999072783 hasRelatedWork W3130516858 @default.
• W1999072783 hasRelatedWork W423997295 @default.

• next