FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999086289> ?p ?o ?g. }

• W1999086289 endingPage "32" @default.
• W1999086289 startingPage "27" @default.
• W1999086289 abstract "A simple plant phenolic acid, protocatechuic acid and a polyphenol, tannic acid are potential chemopreventive agents which inhibited the chemically induced carcinogenesis in many experimental models. We previously demonstrated that those compounds modulate the activity of xenobiotic detoxifying enzymes, including GST in mouse liver, kidney and epidermis. Intraperitoneal (i.p.) treatment with protocatechuic acid in the dose of 80mg/kg for three consecutive days increased the GST activity in liver and kidney. In case of tannic acid the same effect was observed in kidney after i.p. administration of the single dose of 80mg/kg. Topical application of phenolic acids resulted in enhancement of epidermal GST activity. The focus of this study was to further investigate the effects of these phenolic acids on the protein levels of GST isozymes in the same tissues using the treatment protocols used in our previous studies. The results confirmed the expression of GST alfa, mu, pi and theta in mouse liver, kidney and epidermis. Treatment with protocatechuic acid resulted in an increase of the expression of GST class mu in liver, but did not affect this isoform in skin and kidney. This compound inhibited the level of kidney GST pi by 35%. Tannic acid decreased the expression of GST mu, alpha and theta in liver. Application of the equimolar doses of both phenolic acids on mouse skin resulted in reduced level of the GST alpha protein. The results of our study indicate that, although moderate, the effect of protocatechuic acid and tannic acid on GST subunits in mice may play certain role in biological activity of these compounds. Of special importance could be the increased expression of GST mu in liver which is involved in detoxification of many carcinogens including polycyclic aromatic hydrocarbons." @default.
• W1999086289 created "2016-06-24" @default.
• W1999086289 creator A5032077553 @default.
• W1999086289 creator A5044027133 @default.
• W1999086289 creator A5090294516 @default.
• W1999086289 date "2008-01-01" @default.
• W1999086289 modified "2023-10-16" @default.
• W1999086289 title "Hepatic and extrahepatic expression of glutathione S-transferase isozymes in mice and its modulation by naturally occurring phenolic acids" @default.
• W1999086289 cites W1775749144 @default.
• W1999086289 cites W1846230073 @default.
• W1999086289 cites W1968836765 @default.
• W1999086289 cites W1969747613 @default.
• W1999086289 cites W1980998456 @default.
• W1999086289 cites W1989411463 @default.
• W1999086289 cites W1989614044 @default.
• W1999086289 cites W2000869533 @default.
• W1999086289 cites W2004811651 @default.
• W1999086289 cites W2006776638 @default.
• W1999086289 cites W2007179303 @default.
• W1999086289 cites W2013485244 @default.
• W1999086289 cites W2031972213 @default.
• W1999086289 cites W2034109502 @default.
• W1999086289 cites W2047822026 @default.
• W1999086289 cites W2067955906 @default.
• W1999086289 cites W2068075238 @default.
• W1999086289 cites W2071596429 @default.
• W1999086289 cites W2074191613 @default.
• W1999086289 cites W2085786747 @default.
• W1999086289 cites W2097224528 @default.
• W1999086289 cites W2100837269 @default.
• W1999086289 cites W2101108802 @default.
• W1999086289 cites W2105587694 @default.
• W1999086289 cites W2126921546 @default.
• W1999086289 cites W2140587505 @default.
• W1999086289 cites W2141431092 @default.
• W1999086289 cites W2152944981 @default.
• W1999086289 cites W2156279805 @default.
• W1999086289 cites W2160036452 @default.
• W1999086289 cites W2177427245 @default.
• W1999086289 cites W23026567 @default.
• W1999086289 doi "https://doi.org/10.1016/j.etap.2007.08.005" @default.
• W1999086289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21783832" @default.
• W1999086289 hasPublicationYear "2008" @default.
• W1999086289 type Work @default.
• W1999086289 sameAs 1999086289 @default.
• W1999086289 citedByCount "10" @default.
• W1999086289 countsByYear W19990862892012 @default.
• W1999086289 countsByYear W19990862892014 @default.
• W1999086289 countsByYear W19990862892015 @default.
• W1999086289 countsByYear W19990862892017 @default.
• W1999086289 countsByYear W19990862892019 @default.
• W1999086289 countsByYear W19990862892023 @default.
• W1999086289 crossrefType "journal-article" @default.
• W1999086289 hasAuthorship W1999086289A5032077553 @default.
• W1999086289 hasAuthorship W1999086289A5044027133 @default.
• W1999086289 hasAuthorship W1999086289A5090294516 @default.
• W1999086289 hasConcept C119795356 @default.
• W1999086289 hasConcept C134018914 @default.
• W1999086289 hasConcept C178790620 @default.
• W1999086289 hasConcept C181199279 @default.
• W1999086289 hasConcept C185592680 @default.
• W1999086289 hasConcept C2778004101 @default.
• W1999086289 hasConcept C2778778762 @default.
• W1999086289 hasConcept C2780091579 @default.
• W1999086289 hasConcept C2781203734 @default.
• W1999086289 hasConcept C2781393965 @default.
• W1999086289 hasConcept C538909803 @default.
• W1999086289 hasConcept C55493867 @default.
• W1999086289 hasConcept C86803240 @default.
• W1999086289 hasConceptScore W1999086289C119795356 @default.
• W1999086289 hasConceptScore W1999086289C134018914 @default.
• W1999086289 hasConceptScore W1999086289C178790620 @default.
• W1999086289 hasConceptScore W1999086289C181199279 @default.
• W1999086289 hasConceptScore W1999086289C185592680 @default.
• W1999086289 hasConceptScore W1999086289C2778004101 @default.
• W1999086289 hasConceptScore W1999086289C2778778762 @default.
• W1999086289 hasConceptScore W1999086289C2780091579 @default.
• W1999086289 hasConceptScore W1999086289C2781203734 @default.
• W1999086289 hasConceptScore W1999086289C2781393965 @default.
• W1999086289 hasConceptScore W1999086289C538909803 @default.
• W1999086289 hasConceptScore W1999086289C55493867 @default.
• W1999086289 hasConceptScore W1999086289C86803240 @default.
• W1999086289 hasIssue "1" @default.
• W1999086289 hasLocation W19990862891 @default.
• W1999086289 hasLocation W19990862892 @default.
• W1999086289 hasOpenAccess W1999086289 @default.
• W1999086289 hasPrimaryLocation W19990862891 @default.
• W1999086289 hasRelatedWork W1550996414 @default.
• W1999086289 hasRelatedWork W1999086289 @default.
• W1999086289 hasRelatedWork W2037443437 @default.
• W1999086289 hasRelatedWork W2050182051 @default.
• W1999086289 hasRelatedWork W2060038873 @default.
• W1999086289 hasRelatedWork W2163536072 @default.
• W1999086289 hasRelatedWork W2318424018 @default.
• W1999086289 hasRelatedWork W4253727616 @default.
• W1999086289 hasRelatedWork W903917906 @default.
• W1999086289 hasRelatedWork W2469868107 @default.
• W1999086289 hasVolume "25" @default.

• next