FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999098361> ?p ?o ?g. }

• W1999098361 endingPage "1188" @default.
• W1999098361 startingPage "1179" @default.
• W1999098361 abstract "Dendritic cells (DCs) have not been well studied in chronic obstructive pulmonary disease (COPD), yet their integral role in activating and differentiating T cells makes them potential participants in COPD pathogenesis.To determine the expression of maturation molecules by individual DC subsets in relationship to COPD stage and to expression of the acute activation marker CD69 by lung CD4(+) T cells.We nonenzymatically released lung leukocytes from human surgical specimens (n = 42) and used flow cytometry to identify three DC subsets (mDC1, mDC2, and pDC) and to measure their expression of three costimulatory molecules (CD40, CD80 and CD86) and of CD83, the definitive marker of DC maturation. Spearman nonparametric correlation analysis was used to identify significant correlations between expression of DC maturation molecules and COPD severity.Expression of CD40 by mDC1 and mDC2 and of CD86 by mDC2 was high regardless of GOLD stage, but CD80 and CD83 on these two DC subsets increased with disease progression. pDC also showed significant increases in expression of CD40 and CD80. Expression of all but one of the DC molecules that increased with COPD severity also correlated with CD69 expression on lung CD4(+) T cells from the same patients, with the exception of CD83 on mDC2.This cross-sectional study implies that COPD progression is associated with significant increases in costimulatory molecule expression by multiple lung DC subsets. Interactions with lung DCs may contribute to the immunophenotype of CD4(+) T cells in advanced COPD. Clinical trial registered with www.clinicaltrials.gov (NCT00281229)." @default.
• W1999098361 created "2016-06-24" @default.
• W1999098361 creator A5000651180 @default.
• W1999098361 creator A5007274627 @default.
• W1999098361 creator A5008368274 @default.
• W1999098361 creator A5012452800 @default.
• W1999098361 creator A5019468837 @default.
• W1999098361 creator A5026096786 @default.
• W1999098361 creator A5044846381 @default.
• W1999098361 creator A5062970615 @default.
• W1999098361 creator A5080425432 @default.
• W1999098361 creator A5082568705 @default.
• W1999098361 creator A5089258048 @default.
• W1999098361 date "2009-12-15" @default.
• W1999098361 modified "2023-09-27" @default.
• W1999098361 title "Lung Dendritic Cell Expression of Maturation Molecules Increases with Worsening Chronic Obstructive Pulmonary Disease" @default.
• W1999098361 cites W1507248048 @default.
• W1999098361 cites W1542277406 @default.
• W1999098361 cites W1596007839 @default.
• W1999098361 cites W1841444077 @default.
• W1999098361 cites W1917131809 @default.
• W1999098361 cites W1918368808 @default.
• W1999098361 cites W1947375451 @default.
• W1999098361 cites W1967415740 @default.
• W1999098361 cites W1978855332 @default.
• W1999098361 cites W1981699748 @default.
• W1999098361 cites W1983559113 @default.
• W1999098361 cites W1991531286 @default.
• W1999098361 cites W1992439632 @default.
• W1999098361 cites W2022306839 @default.
• W1999098361 cites W2025273503 @default.
• W1999098361 cites W2033877575 @default.
• W1999098361 cites W2056661436 @default.
• W1999098361 cites W2059046642 @default.
• W1999098361 cites W2065006357 @default.
• W1999098361 cites W2066686943 @default.
• W1999098361 cites W2077811143 @default.
• W1999098361 cites W2088593313 @default.
• W1999098361 cites W2094526738 @default.
• W1999098361 cites W2100200230 @default.
• W1999098361 cites W2112478136 @default.
• W1999098361 cites W2113779347 @default.
• W1999098361 cites W2114308840 @default.
• W1999098361 cites W2118537722 @default.
• W1999098361 cites W2118540226 @default.
• W1999098361 cites W2121412233 @default.
• W1999098361 cites W2122363894 @default.
• W1999098361 cites W2124325544 @default.
• W1999098361 cites W2127466319 @default.
• W1999098361 cites W2131424980 @default.
• W1999098361 cites W2135703618 @default.
• W1999098361 cites W2137713574 @default.
• W1999098361 cites W2143412049 @default.
• W1999098361 cites W2145466675 @default.
• W1999098361 cites W2149748445 @default.
• W1999098361 cites W2151821433 @default.
• W1999098361 cites W2155956048 @default.
• W1999098361 cites W2156645716 @default.
• W1999098361 cites W2158722408 @default.
• W1999098361 cites W2161870927 @default.
• W1999098361 cites W2161902022 @default.
• W1999098361 cites W2165600124 @default.
• W1999098361 cites W2171649568 @default.
• W1999098361 cites W2414233154 @default.
• W1999098361 cites W90568390 @default.
• W1999098361 doi "https://doi.org/10.1164/rccm.200904-0552oc" @default.
• W1999098361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2796731" @default.
• W1999098361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19729666" @default.
• W1999098361 hasPublicationYear "2009" @default.
• W1999098361 type Work @default.
• W1999098361 sameAs 1999098361 @default.
• W1999098361 citedByCount "99" @default.
• W1999098361 countsByYear W19990983612012 @default.
• W1999098361 countsByYear W19990983612013 @default.
• W1999098361 countsByYear W19990983612014 @default.
• W1999098361 countsByYear W19990983612015 @default.
• W1999098361 countsByYear W19990983612016 @default.
• W1999098361 countsByYear W19990983612017 @default.
• W1999098361 countsByYear W19990983612018 @default.
• W1999098361 countsByYear W19990983612019 @default.
• W1999098361 countsByYear W19990983612020 @default.
• W1999098361 countsByYear W19990983612021 @default.
• W1999098361 countsByYear W19990983612022 @default.
• W1999098361 countsByYear W19990983612023 @default.
• W1999098361 crossrefType "journal-article" @default.
• W1999098361 hasAuthorship W1999098361A5000651180 @default.
• W1999098361 hasAuthorship W1999098361A5007274627 @default.
• W1999098361 hasAuthorship W1999098361A5008368274 @default.
• W1999098361 hasAuthorship W1999098361A5012452800 @default.
• W1999098361 hasAuthorship W1999098361A5019468837 @default.
• W1999098361 hasAuthorship W1999098361A5026096786 @default.
• W1999098361 hasAuthorship W1999098361A5044846381 @default.
• W1999098361 hasAuthorship W1999098361A5062970615 @default.
• W1999098361 hasAuthorship W1999098361A5080425432 @default.
• W1999098361 hasAuthorship W1999098361A5082568705 @default.
• W1999098361 hasAuthorship W1999098361A5089258048 @default.
• W1999098361 hasBestOaLocation W19990983612 @default.
• W1999098361 hasConcept C126322002 @default.

• next