Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999105655> ?p ?o ?g. }
- W1999105655 endingPage "64" @default.
- W1999105655 startingPage "57" @default.
- W1999105655 abstract "Cortisol, and heat shock protein 70 (HSP70) are known to perform key roles as part of the fish stress response. In the present study, two in vitro systems were used to investigate a possible cortisol-HSP70-apoptosis regulatory relationship. Using a developed silver sea bream fibroblast cell line (SSF), cortisol was found to induce HSP70 synthesis with a concomitant protection against camptothecin induced apoptosis. The induction of HSP70 synthesis using azetidine was also found to protect SSF against apoptosis. A primary culture of silver sea bream macrophages (SSM) displayed reduced HSP70, underwent apoptosis and displayed reduced phagocytic activity upon exposure to cortisol. The effect of cortisol on HSP70 expression in both SSF and SSM were blocked by the glucocorticoid antagonist, RU486. Treatment of SSM with azetidine protected against apoptosis and also enhanced phagocytic activity. The data from this study demonstrates for the first time that cortisol can be either anti- apoptotic or pro-apoptotic in different fish cells and such actions can be mediated via HSP70 induction or suppression respectively." @default.
- W1999105655 created "2016-06-24" @default.
- W1999105655 creator A5035541014 @default.
- W1999105655 creator A5036810769 @default.
- W1999105655 creator A5053742480 @default.
- W1999105655 date "2006-10-01" @default.
- W1999105655 modified "2023-09-23" @default.
- W1999105655 title "Cortisol can be pro- or anti-apoptotic in sea bream cells: Potential role of HSP70 induction for cytoprotection" @default.
- W1999105655 cites W139032385 @default.
- W1999105655 cites W1489400525 @default.
- W1999105655 cites W1577393853 @default.
- W1999105655 cites W1972115601 @default.
- W1999105655 cites W1975572803 @default.
- W1999105655 cites W1989207373 @default.
- W1999105655 cites W2003874924 @default.
- W1999105655 cites W2007501972 @default.
- W1999105655 cites W2015705067 @default.
- W1999105655 cites W2020357295 @default.
- W1999105655 cites W2021216016 @default.
- W1999105655 cites W2036389563 @default.
- W1999105655 cites W2036472708 @default.
- W1999105655 cites W2037297577 @default.
- W1999105655 cites W2043076168 @default.
- W1999105655 cites W2051793369 @default.
- W1999105655 cites W2053074248 @default.
- W1999105655 cites W2056337891 @default.
- W1999105655 cites W2056686888 @default.
- W1999105655 cites W2062775685 @default.
- W1999105655 cites W2063882601 @default.
- W1999105655 cites W2065990305 @default.
- W1999105655 cites W2068688726 @default.
- W1999105655 cites W2078020687 @default.
- W1999105655 cites W2079115295 @default.
- W1999105655 cites W2083137728 @default.
- W1999105655 cites W2083549154 @default.
- W1999105655 cites W2084036708 @default.
- W1999105655 cites W2085046609 @default.
- W1999105655 cites W2088464932 @default.
- W1999105655 cites W2100837269 @default.
- W1999105655 cites W2104941151 @default.
- W1999105655 cites W2111858669 @default.
- W1999105655 cites W2113836064 @default.
- W1999105655 cites W2120593951 @default.
- W1999105655 cites W2130196766 @default.
- W1999105655 cites W2130632058 @default.
- W1999105655 cites W2135603335 @default.
- W1999105655 cites W2136061619 @default.
- W1999105655 cites W2140797773 @default.
- W1999105655 cites W2146611582 @default.
- W1999105655 cites W2147262386 @default.
- W1999105655 cites W2150882718 @default.
- W1999105655 cites W2151167387 @default.
- W1999105655 cites W2151975923 @default.
- W1999105655 cites W2164781217 @default.
- W1999105655 cites W2168601768 @default.
- W1999105655 cites W2183044194 @default.
- W1999105655 cites W2185419453 @default.
- W1999105655 cites W40830852 @default.
- W1999105655 cites W4243484967 @default.
- W1999105655 cites W4293247451 @default.
- W1999105655 doi "https://doi.org/10.1016/j.mce.2006.08.006" @default.
- W1999105655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16989943" @default.
- W1999105655 hasPublicationYear "2006" @default.
- W1999105655 type Work @default.
- W1999105655 sameAs 1999105655 @default.
- W1999105655 citedByCount "27" @default.
- W1999105655 countsByYear W19991056552012 @default.
- W1999105655 countsByYear W19991056552014 @default.
- W1999105655 countsByYear W19991056552018 @default.
- W1999105655 countsByYear W19991056552019 @default.
- W1999105655 countsByYear W19991056552021 @default.
- W1999105655 countsByYear W19991056552022 @default.
- W1999105655 crossrefType "journal-article" @default.
- W1999105655 hasAuthorship W1999105655A5035541014 @default.
- W1999105655 hasAuthorship W1999105655A5036810769 @default.
- W1999105655 hasAuthorship W1999105655A5053742480 @default.
- W1999105655 hasConcept C104317684 @default.
- W1999105655 hasConcept C126322002 @default.
- W1999105655 hasConcept C134018914 @default.
- W1999105655 hasConcept C137984847 @default.
- W1999105655 hasConcept C190283241 @default.
- W1999105655 hasConcept C205260736 @default.
- W1999105655 hasConcept C2780841215 @default.
- W1999105655 hasConcept C2780967304 @default.
- W1999105655 hasConcept C55493867 @default.
- W1999105655 hasConcept C68991219 @default.
- W1999105655 hasConcept C71924100 @default.
- W1999105655 hasConcept C86803240 @default.
- W1999105655 hasConcept C95444343 @default.
- W1999105655 hasConcept C98274493 @default.
- W1999105655 hasConceptScore W1999105655C104317684 @default.
- W1999105655 hasConceptScore W1999105655C126322002 @default.
- W1999105655 hasConceptScore W1999105655C134018914 @default.
- W1999105655 hasConceptScore W1999105655C137984847 @default.
- W1999105655 hasConceptScore W1999105655C190283241 @default.
- W1999105655 hasConceptScore W1999105655C205260736 @default.
- W1999105655 hasConceptScore W1999105655C2780841215 @default.
- W1999105655 hasConceptScore W1999105655C2780967304 @default.