Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999106225> ?p ?o ?g. }
- W1999106225 endingPage "5239" @default.
- W1999106225 startingPage "5230" @default.
- W1999106225 abstract "Paranodal junctions of myelinated nerve fibers are important for saltatory conduction and function as paracellular and membrane protein diffusion barriers flanking nodes of Ranvier. The formation of these specialized axoglial contacts depends on the presence of three cell adhesion molecules: neurofascin 155 on the glial membrane and a complex of Caspr and contactin on the axon. We isolated axonal and glial membranes highly enriched in these paranodal proteins and then used mass spectrometry to identify additional proteins associated with the paranodal axoglial junction. This strategy led to the identification of three novel components of the paranodal cytoskeleton: ankyrinB, alphaII spectrin, and betaII spectrin. Biochemical and immunohistochemical analyses revealed that these proteins associate with protein 4.1B in a macromolecular complex that is concentrated at central and peripheral paranodal junctions in the adult and during early myelination. Furthermore, we show that the paranodal localization of ankyrinB is disrupted in Caspr-null mice with aberrant paranodal junctions, demonstrating that paranodal neuron-glia interactions regulate the organization of the underlying cytoskeleton. In contrast, genetic disruption of the juxtaparanodal protein Caspr2 or the nodal cytoskeletal protein betaIV spectrin did not alter the paranodal cytoskeleton. Our results demonstrate that the paranodal junction contains specialized cytoskeletal components that may be important to stabilize axon-glia interactions and contribute to the membrane protein diffusion barrier found at paranodes." @default.
- W1999106225 created "2016-06-24" @default.
- W1999106225 creator A5006212346 @default.
- W1999106225 creator A5022184232 @default.
- W1999106225 creator A5023333671 @default.
- W1999106225 creator A5049402959 @default.
- W1999106225 creator A5049692788 @default.
- W1999106225 creator A5052741211 @default.
- W1999106225 creator A5069256973 @default.
- W1999106225 creator A5076802517 @default.
- W1999106225 creator A5080455465 @default.
- W1999106225 creator A5083792674 @default.
- W1999106225 date "2006-05-10" @default.
- W1999106225 modified "2023-09-24" @default.
- W1999106225 title "Spectrins and AnkyrinB Constitute a Specialized Paranodal Cytoskeleton" @default.
- W1999106225 cites W1560117306 @default.
- W1999106225 cites W1560962269 @default.
- W1999106225 cites W1579742067 @default.
- W1999106225 cites W1604240807 @default.
- W1999106225 cites W1633357948 @default.
- W1999106225 cites W1788586683 @default.
- W1999106225 cites W1876993892 @default.
- W1999106225 cites W1910325974 @default.
- W1999106225 cites W1964796114 @default.
- W1999106225 cites W1966721481 @default.
- W1999106225 cites W1971203163 @default.
- W1999106225 cites W1978553600 @default.
- W1999106225 cites W1979651668 @default.
- W1999106225 cites W1982110038 @default.
- W1999106225 cites W1983352835 @default.
- W1999106225 cites W1983774046 @default.
- W1999106225 cites W1984357699 @default.
- W1999106225 cites W1994853599 @default.
- W1999106225 cites W1998139699 @default.
- W1999106225 cites W2004104083 @default.
- W1999106225 cites W2005148481 @default.
- W1999106225 cites W2011028001 @default.
- W1999106225 cites W2012377585 @default.
- W1999106225 cites W2017281603 @default.
- W1999106225 cites W2033435068 @default.
- W1999106225 cites W2035573045 @default.
- W1999106225 cites W2039469316 @default.
- W1999106225 cites W2040101283 @default.
- W1999106225 cites W2041388242 @default.
- W1999106225 cites W2046096403 @default.
- W1999106225 cites W2047990013 @default.
- W1999106225 cites W2055906173 @default.
- W1999106225 cites W2059241499 @default.
- W1999106225 cites W2065200510 @default.
- W1999106225 cites W2070691915 @default.
- W1999106225 cites W2079735011 @default.
- W1999106225 cites W2081186536 @default.
- W1999106225 cites W2085241987 @default.
- W1999106225 cites W2086125969 @default.
- W1999106225 cites W2094448070 @default.
- W1999106225 cites W2095044668 @default.
- W1999106225 cites W2097049394 @default.
- W1999106225 cites W2097396891 @default.
- W1999106225 cites W2106492868 @default.
- W1999106225 cites W2106512080 @default.
- W1999106225 cites W2119219767 @default.
- W1999106225 cites W2122971055 @default.
- W1999106225 cites W2131255875 @default.
- W1999106225 cites W2164425582 @default.
- W1999106225 cites W2165094762 @default.
- W1999106225 cites W2167991458 @default.
- W1999106225 cites W2327949265 @default.
- W1999106225 cites W2330047351 @default.
- W1999106225 doi "https://doi.org/10.1523/jneurosci.0425-06.2006" @default.
- W1999106225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674250" @default.
- W1999106225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16687515" @default.
- W1999106225 hasPublicationYear "2006" @default.
- W1999106225 type Work @default.
- W1999106225 sameAs 1999106225 @default.
- W1999106225 citedByCount "144" @default.
- W1999106225 countsByYear W19991062252012 @default.
- W1999106225 countsByYear W19991062252013 @default.
- W1999106225 countsByYear W19991062252014 @default.
- W1999106225 countsByYear W19991062252015 @default.
- W1999106225 countsByYear W19991062252016 @default.
- W1999106225 countsByYear W19991062252017 @default.
- W1999106225 countsByYear W19991062252018 @default.
- W1999106225 countsByYear W19991062252019 @default.
- W1999106225 countsByYear W19991062252020 @default.
- W1999106225 countsByYear W19991062252021 @default.
- W1999106225 countsByYear W19991062252022 @default.
- W1999106225 countsByYear W19991062252023 @default.
- W1999106225 crossrefType "journal-article" @default.
- W1999106225 hasAuthorship W1999106225A5006212346 @default.
- W1999106225 hasAuthorship W1999106225A5022184232 @default.
- W1999106225 hasAuthorship W1999106225A5023333671 @default.
- W1999106225 hasAuthorship W1999106225A5049402959 @default.
- W1999106225 hasAuthorship W1999106225A5049692788 @default.
- W1999106225 hasAuthorship W1999106225A5052741211 @default.
- W1999106225 hasAuthorship W1999106225A5069256973 @default.
- W1999106225 hasAuthorship W1999106225A5076802517 @default.
- W1999106225 hasAuthorship W1999106225A5080455465 @default.
- W1999106225 hasAuthorship W1999106225A5083792674 @default.