FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999109058> ?p ?o ?g. }

• W1999109058 endingPage "5079" @default.
• W1999109058 startingPage "5074" @default.
• W1999109058 abstract "Recent studies suggest that Cu/Zn superoxide dismutase (SOD1) could be pathogenic in both familial and sporadic amyotrophic lateral sclerosis (ALS) through either inheritable or nonheritable modifications. The presence of a misfolded WT SOD1 in patients with sporadic ALS, along with the recently reported evidence that reducing SOD1 levels in astrocytes derived from sporadic patients inhibits astrocyte-mediated toxicity on motor neurons, suggest that WT SOD1 may acquire toxic properties similar to familial ALS-linked mutant SOD1, perhaps through posttranslational modifications. Using patients’ lymphoblasts, we show here that indeed WT SOD1 is modified posttranslationally in sporadic ALS and is iper-oxidized (i.e., above baseline oxidation levels) in a subset of patients with bulbar onset. Derivatization analysis of oxidized carbonyl compounds performed on immunoprecipitated SOD1 identified an iper-oxidized SOD1 that recapitulates mutant SOD1-like properties and damages mitochondria by forming a toxic complex with mitochondrial Bcl-2. This study conclusively demonstrates the existence of an iper-oxidized SOD1 with toxic properties in patient-derived cells and identifies a common SOD1-dependent toxicity between mutant SOD1-linked familial ALS and a subset of sporadic ALS, providing an opportunity to develop biomarkers to subclassify ALS and devise SOD1-based therapies that go beyond the small group of patients with mutant SOD1." @default.
• W1999109058 created "2016-06-24" @default.
• W1999109058 creator A5007864376 @default.
• W1999109058 creator A5009669782 @default.
• W1999109058 creator A5015273408 @default.
• W1999109058 creator A5029855257 @default.
• W1999109058 creator A5059444134 @default.
• W1999109058 creator A5070964311 @default.
• W1999109058 creator A5078857071 @default.
• W1999109058 creator A5085021881 @default.
• W1999109058 date "2012-03-13" @default.
• W1999109058 modified "2023-10-16" @default.
• W1999109058 title "An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1" @default.
• W1999109058 cites W1963947961 @default.
• W1999109058 cites W1994600281 @default.
• W1999109058 cites W2004950164 @default.
• W1999109058 cites W2009434886 @default.
• W1999109058 cites W2011007124 @default.
• W1999109058 cites W2015266340 @default.
• W1999109058 cites W2032269048 @default.
• W1999109058 cites W2046002256 @default.
• W1999109058 cites W2054424443 @default.
• W1999109058 cites W2059355164 @default.
• W1999109058 cites W2072981065 @default.
• W1999109058 cites W2073987119 @default.
• W1999109058 cites W2077041830 @default.
• W1999109058 cites W2082705131 @default.
• W1999109058 cites W2096386031 @default.
• W1999109058 cites W2099065983 @default.
• W1999109058 cites W2100111801 @default.
• W1999109058 cites W2106819616 @default.
• W1999109058 cites W2113780113 @default.
• W1999109058 cites W2123779560 @default.
• W1999109058 cites W2128815118 @default.
• W1999109058 cites W2150430904 @default.
• W1999109058 cites W2150523249 @default.
• W1999109058 cites W2154945114 @default.
• W1999109058 cites W2155235678 @default.
• W1999109058 cites W2156046858 @default.
• W1999109058 cites W2157076525 @default.
• W1999109058 cites W2171303338 @default.
• W1999109058 cites W2232671867 @default.
• W1999109058 cites W4295135156 @default.
• W1999109058 doi "https://doi.org/10.1073/pnas.1115402109" @default.
• W1999109058 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3324021" @default.
• W1999109058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22416121" @default.
• W1999109058 hasPublicationYear "2012" @default.
• W1999109058 type Work @default.
• W1999109058 sameAs 1999109058 @default.
• W1999109058 citedByCount "163" @default.
• W1999109058 countsByYear W19991090582012 @default.
• W1999109058 countsByYear W19991090582013 @default.
• W1999109058 countsByYear W19991090582014 @default.
• W1999109058 countsByYear W19991090582015 @default.
• W1999109058 countsByYear W19991090582016 @default.
• W1999109058 countsByYear W19991090582017 @default.
• W1999109058 countsByYear W19991090582018 @default.
• W1999109058 countsByYear W19991090582019 @default.
• W1999109058 countsByYear W19991090582020 @default.
• W1999109058 countsByYear W19991090582021 @default.
• W1999109058 countsByYear W19991090582022 @default.
• W1999109058 countsByYear W19991090582023 @default.
• W1999109058 crossrefType "journal-article" @default.
• W1999109058 hasAuthorship W1999109058A5007864376 @default.
• W1999109058 hasAuthorship W1999109058A5009669782 @default.
• W1999109058 hasAuthorship W1999109058A5015273408 @default.
• W1999109058 hasAuthorship W1999109058A5029855257 @default.
• W1999109058 hasAuthorship W1999109058A5059444134 @default.
• W1999109058 hasAuthorship W1999109058A5070964311 @default.
• W1999109058 hasAuthorship W1999109058A5078857071 @default.
• W1999109058 hasAuthorship W1999109058A5085021881 @default.
• W1999109058 hasBestOaLocation W19991090581 @default.
• W1999109058 hasConcept C104317684 @default.
• W1999109058 hasConcept C142724271 @default.
• W1999109058 hasConcept C143065580 @default.
• W1999109058 hasConcept C185592680 @default.
• W1999109058 hasConcept C2775838275 @default.
• W1999109058 hasConcept C2776151105 @default.
• W1999109058 hasConcept C2777615887 @default.
• W1999109058 hasConcept C2779134260 @default.
• W1999109058 hasConcept C2780596555 @default.
• W1999109058 hasConcept C28859421 @default.
• W1999109058 hasConcept C55493867 @default.
• W1999109058 hasConcept C71924100 @default.
• W1999109058 hasConceptScore W1999109058C104317684 @default.
• W1999109058 hasConceptScore W1999109058C142724271 @default.
• W1999109058 hasConceptScore W1999109058C143065580 @default.
• W1999109058 hasConceptScore W1999109058C185592680 @default.
• W1999109058 hasConceptScore W1999109058C2775838275 @default.
• W1999109058 hasConceptScore W1999109058C2776151105 @default.
• W1999109058 hasConceptScore W1999109058C2777615887 @default.
• W1999109058 hasConceptScore W1999109058C2779134260 @default.
• W1999109058 hasConceptScore W1999109058C2780596555 @default.
• W1999109058 hasConceptScore W1999109058C28859421 @default.
• W1999109058 hasConceptScore W1999109058C55493867 @default.
• W1999109058 hasConceptScore W1999109058C71924100 @default.
• W1999109058 hasIssue "13" @default.
• W1999109058 hasLocation W19991090581 @default.

• next