FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999123701> ?p ?o ?g. }

• W1999123701 endingPage "14205" @default.
• W1999123701 startingPage "14200" @default.
• W1999123701 abstract "Activation of the retinoblastoma (RB) protein through dephosphorylation arises in cells upon exit from M phase and in response to environmental stresses, including DNA damage. We provide here for the first time evidence that these responses are co-ordinately affected in a subset of tumor derived cell lines. We find that RB dephosphorylation is not apparent in these cells during progression into G(1). Importantly these cells also do not respond with RB activation after DNA damage during S phase. Moreover and as a consequence they display phenotypes classically associated with RB(-) cells, showing accelerated apoptosis after DNA damage and DNA re-replication after spindle-checkpoint activation. A large body of literature provides evidence that controls governing inactivation of RB are lost in tumors. The results presented here indicate that the reverse reaction, namely the activation of RB from an inactive precursor, may also be compromised. Our findings indicate that this type of defect may be coupled with hypersensitivity to DNA damage and an increase in genomic instability in response to spindle-checkpoint activation thus bearing potentially important medical implications." @default.
• W1999123701 created "2016-06-24" @default.
• W1999123701 creator A5016939749 @default.
• W1999123701 creator A5040494686 @default.
• W1999123701 creator A5072840888 @default.
• W1999123701 date "2002-10-11" @default.
• W1999123701 modified "2023-09-24" @default.
• W1999123701 title "RB activation defect in tumor cell lines" @default.
• W1999123701 cites W1486122524 @default.
• W1999123701 cites W1574250061 @default.
• W1999123701 cites W1622642497 @default.
• W1999123701 cites W1972027777 @default.
• W1999123701 cites W1978834938 @default.
• W1999123701 cites W1983371173 @default.
• W1999123701 cites W1988058940 @default.
• W1999123701 cites W1991155290 @default.
• W1999123701 cites W1995690959 @default.
• W1999123701 cites W2009951223 @default.
• W1999123701 cites W2014285665 @default.
• W1999123701 cites W2042976610 @default.
• W1999123701 cites W2044583546 @default.
• W1999123701 cites W2055077352 @default.
• W1999123701 cites W2086521820 @default.
• W1999123701 cites W2105933029 @default.
• W1999123701 cites W2141599538 @default.
• W1999123701 cites W2145862670 @default.
• W1999123701 cites W2150451425 @default.
• W1999123701 cites W2152616419 @default.
• W1999123701 cites W2158054272 @default.
• W1999123701 cites W2407171714 @default.
• W1999123701 cites W2416254354 @default.
• W1999123701 cites W4237282615 @default.
• W1999123701 doi "https://doi.org/10.1073/pnas.212519499" @default.
• W1999123701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/137861" @default.
• W1999123701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12379745" @default.
• W1999123701 hasPublicationYear "2002" @default.
• W1999123701 type Work @default.
• W1999123701 sameAs 1999123701 @default.
• W1999123701 citedByCount "40" @default.
• W1999123701 countsByYear W19991237012012 @default.
• W1999123701 countsByYear W19991237012013 @default.
• W1999123701 countsByYear W19991237012014 @default.
• W1999123701 countsByYear W19991237012015 @default.
• W1999123701 countsByYear W19991237012017 @default.
• W1999123701 countsByYear W19991237012019 @default.
• W1999123701 countsByYear W19991237012020 @default.
• W1999123701 countsByYear W19991237012021 @default.
• W1999123701 crossrefType "journal-article" @default.
• W1999123701 hasAuthorship W1999123701A5016939749 @default.
• W1999123701 hasAuthorship W1999123701A5040494686 @default.
• W1999123701 hasAuthorship W1999123701A5072840888 @default.
• W1999123701 hasBestOaLocation W19991237011 @default.
• W1999123701 hasConcept C11960822 @default.
• W1999123701 hasConcept C134935766 @default.
• W1999123701 hasConcept C143425029 @default.
• W1999123701 hasConcept C153911025 @default.
• W1999123701 hasConcept C178169997 @default.
• W1999123701 hasConcept C178666793 @default.
• W1999123701 hasConcept C181912034 @default.
• W1999123701 hasConcept C185592680 @default.
• W1999123701 hasConcept C190283241 @default.
• W1999123701 hasConcept C2776062698 @default.
• W1999123701 hasConcept C29537977 @default.
• W1999123701 hasConcept C502942594 @default.
• W1999123701 hasConcept C54355233 @default.
• W1999123701 hasConcept C552990157 @default.
• W1999123701 hasConcept C73573662 @default.
• W1999123701 hasConcept C86803240 @default.
• W1999123701 hasConcept C95444343 @default.
• W1999123701 hasConceptScore W1999123701C11960822 @default.
• W1999123701 hasConceptScore W1999123701C134935766 @default.
• W1999123701 hasConceptScore W1999123701C143425029 @default.
• W1999123701 hasConceptScore W1999123701C153911025 @default.
• W1999123701 hasConceptScore W1999123701C178169997 @default.
• W1999123701 hasConceptScore W1999123701C178666793 @default.
• W1999123701 hasConceptScore W1999123701C181912034 @default.
• W1999123701 hasConceptScore W1999123701C185592680 @default.
• W1999123701 hasConceptScore W1999123701C190283241 @default.
• W1999123701 hasConceptScore W1999123701C2776062698 @default.
• W1999123701 hasConceptScore W1999123701C29537977 @default.
• W1999123701 hasConceptScore W1999123701C502942594 @default.
• W1999123701 hasConceptScore W1999123701C54355233 @default.
• W1999123701 hasConceptScore W1999123701C552990157 @default.
• W1999123701 hasConceptScore W1999123701C73573662 @default.
• W1999123701 hasConceptScore W1999123701C86803240 @default.
• W1999123701 hasConceptScore W1999123701C95444343 @default.
• W1999123701 hasIssue "22" @default.
• W1999123701 hasLocation W19991237011 @default.
• W1999123701 hasLocation W19991237012 @default.
• W1999123701 hasLocation W19991237013 @default.
• W1999123701 hasLocation W19991237014 @default.
• W1999123701 hasOpenAccess W1999123701 @default.
• W1999123701 hasPrimaryLocation W19991237011 @default.
• W1999123701 hasRelatedWork W1604055027 @default.
• W1999123701 hasRelatedWork W1975936119 @default.
• W1999123701 hasRelatedWork W1996366132 @default.
• W1999123701 hasRelatedWork W2050243029 @default.
• W1999123701 hasRelatedWork W2111765047 @default.

• next