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- W1999146206 abstract "Chemotaxis of the bacterium Escherichia coli serves as a paradigm for the way living cells respond and adapt to changes in their environment. The chemotactic response has been well characterized at the level of individual flagellar motors and in populations of swimming cells. However, it is unknown how the interactions of multiple flagella combine to produce the whole-cell swimming response. Until now it has not been possible to accurately quantify the adaptive response of a single, multi-flagellated cell. We used our recently developed optical trapping technique1 to characterize the swimming behavior of individual bacteria as they respond to sudden changes in the chemical environment. Our assay allows us to quantify two features of adaptation, and how they vary as a function of the stimulus strength: abruptness, the degree to which adaptation occurs within a small number of run-tumble events; and overshoot, the degree of excessive response before the return to pre-stimulus behavior. In the effort to understand these new features and relate the activity of individual flagella to whole-cell swimming behavior, we have recently developed the ability to record high speed (500fps) movies of fluorescently labeled flagella on trapped cells. This allows us to observe individual flagella, while simultaneously quantifying long-term swimming behavior. We discuss all of our findings in the context of theoretical models of the chemotaxis network, and suggest how these findings provide clues to an improved understanding of chemotactic adaptation.1. Min, Mears, et al. 2009 Nov; Nature Methods 6(11):831–5." @default.
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- W1999146206 date "2012-01-01" @default.
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- W1999146206 title "Using Optical Traps to Study Bacterial Motility and Chemotaxis at the Single-Cell Level" @default.
- W1999146206 doi "https://doi.org/10.1016/j.bpj.2011.11.873" @default.
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