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- W1999156845 abstract "Abstract The role of electrostatic forces in the interaction between local anesthetics and phospholipid membranes has been well studied previously. The present work tested the hypothesis that the tertiary amine local anesthetics can also interact with charged groups that may be present on membrane proteins. The rotational mobility of a spin-labeled local anesthetic, 2-[N-methyl-N-(2,2,6.6-tetramethylpiperi-dinooxyl)] ethyl p-hexyloxybenzoate, in erythrocyte membranes was found to decrease upon addition of chemical modifiers that react covalently with free amino groups of the membrane and decrease the concentration of the membrane's fixed positive charge. Reagents that did not react with free amino groups, or those that did react with amino groups but did not alter the net charge of the membrane, had no effect on the mobility of the spin-labeled local anesthetic. The decrease in the anesthetic's mobility found after reaction with amino-directed reagents was shown to be due to the attraction of the positively charged anesthetic to the modified site. The immobilization of the anesthetics was primarily due to modification of the membrane protein components. The immobilized anesthetics are most probably located at the inner surface of the membrane." @default.
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- W1999156845 title "The effect of chemical modifiers on the interaction of a spin-labeled local anesthetic with human erythrocyte membranes" @default.
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- W1999156845 doi "https://doi.org/10.1016/0006-2952(76)90111-8" @default.
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