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- W1999161768 abstract "Cardiopep is an acronym for cardioactive polypeptide. It is a newly isolated fraction of bee venom with an estimated molecular weight of 1940. The cardiovascular effects of cardiopep have been studied in a series of 30 isolated perfused Langendorff heart preparations, and in 12 intact animals. When injected into the coronary circulation of the perfused heart, cardiopep produces a 50 ± 10 per cent increase in rate, a 150 ± 50 per cent increase in force of contraction and no change in coronary vascular resistance. These effects lasted for the duration of the experiment. In those hearts in which intrinsic arrhythmias are present, a dose of 0·2 mg of cardiopep produced an immediate restoration of normal cardiac rhythm in addition to the effects on rate and force. In the intact monkey preparation, this same dose of cardiopep produces an increase in heart rate, aortic blood flow and right ventricular force. There are no significant changes in arterial blood pressure, central venous pressure or cortical activity. In addition cardiopep appears to be relatively nontoxic (LD50 = 15 mg/kg) when compared to whole bee venom (LD50 = 3·5 mg/kg). It would appear from these studies that cardiopep is a potent, nontoxic beta-adrenergic-like stimulant not entirely blocked by propranolol and possessing definite anti-arrhythmic properties." @default.
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- W1999161768 date "1974-03-01" @default.
- W1999161768 modified "2023-09-24" @default.
- W1999161768 title "Beta adrenergic and anti-arrhythmic effects of cardiopep, a newly isolated substance from whole bee venom" @default.
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- W1999161768 doi "https://doi.org/10.1016/0041-0101(74)90237-2" @default.
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