FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999180573> ?p ?o ?g. }

• W1999180573 abstract "Calcitonin gene-related peptide (CGRP) has a key role in migraine pathophysiology and is associated with activation of the trigeminovascular system. The trigeminal ganglion, storing CGRP and its receptor components, projects peripheral to the intracranial vasculature and central to regions in the brainstem with Aδ- and C-fibers; this constitutes an essential part of the pain pathways activated in migraine attacks. Therefore it is of importance to identify the regions within the brainstem that processes nociceptive information from the trigeminovascular system, such as the spinal trigeminal nucleus (STN) and the C1-level of the spinal cord. Immunohistochemistry was used to study the distribution and relation between CGRP and its receptor components - calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1) - in human and rat STN and at the C1-level, using a set of newly well characterized antibodies. In addition, double-stainings with CGRP and myelin basic protein (MBP, myelin), synaptophysin (synaptic vesicles) or IB4 (C-fibers in general) were performed. In the STN, the highest density of CGRP immunoreactive fibers were found in a network around fiber bundles in the superficial laminae. CLR and RAMP1 expression were predominately found in fibers in the spinal trigeminal tract region, with some fibers spanning into the superficial laminae. Co-localization between CGRP and its receptor components was not noted. In C1, CGRP was expressed in fibers of laminae I and II. The CGRP staining was similar in rat, except for CGRP positive neurons that were found close to the central canal. In C1, the receptor components were detected in laminae I and II, however these fibers were distinct from fibers expressing CGRP as verified by confocal microscopy. This study demonstrates the detailed expression of CGRP and its receptor components within STN in the brainstem and in the spinal cord at C1-level, and shows the possibility of CGRP acting postjunctionally in these areas putatively involved in primary headaches." @default.
• W1999180573 created "2016-06-24" @default.
• W1999180573 creator A5042139121 @default.
• W1999180573 creator A5084413123 @default.
• W1999180573 date "2011-11-10" @default.
• W1999180573 modified "2023-10-04" @default.
• W1999180573 title "Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level" @default.
• W1999180573 cites W1506673182 @default.
• W1999180573 cites W1969275361 @default.
• W1999180573 cites W1970846628 @default.
• W1999180573 cites W1973662774 @default.
• W1999180573 cites W1977067039 @default.
• W1999180573 cites W1978702138 @default.
• W1999180573 cites W1982394915 @default.
• W1999180573 cites W1982703295 @default.
• W1999180573 cites W1987697087 @default.
• W1999180573 cites W1988565149 @default.
• W1999180573 cites W1989871310 @default.
• W1999180573 cites W1991934679 @default.
• W1999180573 cites W2007980154 @default.
• W1999180573 cites W2010648377 @default.
• W1999180573 cites W2018165321 @default.
• W1999180573 cites W2022091918 @default.
• W1999180573 cites W2029611164 @default.
• W1999180573 cites W2041847544 @default.
• W1999180573 cites W2046951924 @default.
• W1999180573 cites W2048132386 @default.
• W1999180573 cites W2048821374 @default.
• W1999180573 cites W2049876031 @default.
• W1999180573 cites W2067231489 @default.
• W1999180573 cites W2069041929 @default.
• W1999180573 cites W2071181481 @default.
• W1999180573 cites W2075190704 @default.
• W1999180573 cites W2084093310 @default.
• W1999180573 cites W2084801155 @default.
• W1999180573 cites W2085872316 @default.
• W1999180573 cites W2087734088 @default.
• W1999180573 cites W2095859169 @default.
• W1999180573 cites W2098988727 @default.
• W1999180573 cites W2111112233 @default.
• W1999180573 cites W2135858080 @default.
• W1999180573 cites W2142154103 @default.
• W1999180573 cites W2154996109 @default.
• W1999180573 cites W4246001062 @default.
• W1999180573 doi "https://doi.org/10.1186/1471-2202-12-112" @default.
• W1999180573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3282678" @default.
• W1999180573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22074408" @default.
• W1999180573 hasPublicationYear "2011" @default.
• W1999180573 type Work @default.
• W1999180573 sameAs 1999180573 @default.
• W1999180573 citedByCount "130" @default.
• W1999180573 countsByYear W19991805732012 @default.
• W1999180573 countsByYear W19991805732013 @default.
• W1999180573 countsByYear W19991805732014 @default.
• W1999180573 countsByYear W19991805732015 @default.
• W1999180573 countsByYear W19991805732016 @default.
• W1999180573 countsByYear W19991805732017 @default.
• W1999180573 countsByYear W19991805732018 @default.
• W1999180573 countsByYear W19991805732019 @default.
• W1999180573 countsByYear W19991805732020 @default.
• W1999180573 countsByYear W19991805732021 @default.
• W1999180573 countsByYear W19991805732022 @default.
• W1999180573 countsByYear W19991805732023 @default.
• W1999180573 crossrefType "journal-article" @default.
• W1999180573 hasAuthorship W1999180573A5042139121 @default.
• W1999180573 hasAuthorship W1999180573A5084413123 @default.
• W1999180573 hasBestOaLocation W19991805731 @default.
• W1999180573 hasConcept C105702510 @default.
• W1999180573 hasConcept C118303440 @default.
• W1999180573 hasConcept C126322002 @default.
• W1999180573 hasConcept C15490471 @default.
• W1999180573 hasConcept C163170386 @default.
• W1999180573 hasConcept C169760540 @default.
• W1999180573 hasConcept C170493617 @default.
• W1999180573 hasConcept C185592680 @default.
• W1999180573 hasConcept C2776352249 @default.
• W1999180573 hasConcept C2776700747 @default.
• W1999180573 hasConcept C2780775167 @default.
• W1999180573 hasConcept C551621295 @default.
• W1999180573 hasConcept C71924100 @default.
• W1999180573 hasConcept C86803240 @default.
• W1999180573 hasConcept C92316933 @default.
• W1999180573 hasConcept C94487597 @default.
• W1999180573 hasConceptScore W1999180573C105702510 @default.
• W1999180573 hasConceptScore W1999180573C118303440 @default.
• W1999180573 hasConceptScore W1999180573C126322002 @default.
• W1999180573 hasConceptScore W1999180573C15490471 @default.
• W1999180573 hasConceptScore W1999180573C163170386 @default.
• W1999180573 hasConceptScore W1999180573C169760540 @default.
• W1999180573 hasConceptScore W1999180573C170493617 @default.
• W1999180573 hasConceptScore W1999180573C185592680 @default.
• W1999180573 hasConceptScore W1999180573C2776352249 @default.
• W1999180573 hasConceptScore W1999180573C2776700747 @default.
• W1999180573 hasConceptScore W1999180573C2780775167 @default.
• W1999180573 hasConceptScore W1999180573C551621295 @default.
• W1999180573 hasConceptScore W1999180573C71924100 @default.
• W1999180573 hasConceptScore W1999180573C86803240 @default.
• W1999180573 hasConceptScore W1999180573C92316933 @default.
• W1999180573 hasConceptScore W1999180573C94487597 @default.
• W1999180573 hasIssue "1" @default.

• next