FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999191657> ?p ?o ?g. }

• W1999191657 endingPage "605" @default.
• W1999191657 startingPage "593" @default.
• W1999191657 abstract "1. Myocytes were dissociated from the sinoatrial (SA) node of rat heart using a new enzymatic dissociation technique. Only a small number of isolated SA node myocytes showed regular rhythmic contractions and spontaneous action potentials, and these were used in the present study. 2. The spontaneous action potential was resistant to TTX, and the action potential parameters were similar to those of rabbit and guinea-pig pacemaker cells. Major time- and voltage-dependent currents were the delayed rectifier K+ current IKr, the L-type Ca2+ current ICa,L and the sodium current INa. The hyperpolarization-activated cation current (If) was recorded from approximately 50 % of the cells with hyperpolarization beyond -90 mV. 3. The instantaneous current jump at the onset of a hyperpolarizing pulse showed inward rectification and was largely blocked by Ba2+. This Ba2+-sensitive current corresponded well to the inward rectifier K+ current (IK1), although it was much smaller in amplitude than in the ventricle. 4. A sustained inward current was activated on depolarization from -80 mV to the voltage range of slow diastolic depolarization. The current was blocked by nicardipine, enlarged by isoprenaline and was insensitive to removal of external Ca2+. These characteristics were similar to the sustained inward current, Ist, previously described in the rabbit and guinea-pig SA node cells. 5. The role of Ist was considered by constructing empirical equations, which were applied to the experimental record of the action potential. It is demonstrated that the voltage-dependent activation of Ist constitutes a positive feedback loop with the depolarization of the membrane." @default.
• W1999191657 created "2016-06-24" @default.
• W1999191657 creator A5074482591 @default.
• W1999191657 creator A5080062563 @default.
• W1999191657 creator A5087139089 @default.
• W1999191657 date "2000-03-01" @default.
• W1999191657 modified "2023-09-26" @default.
• W1999191657 title "The sustained inward current and inward rectifier K⁺ current in pacemaker cells dissociated from rat sinoatrial node" @default.
• W1999191657 cites W10522707 @default.
• W1999191657 cites W1968560076 @default.
• W1999191657 cites W1970081505 @default.
• W1999191657 cites W1974222702 @default.
• W1999191657 cites W1975382475 @default.
• W1999191657 cites W1983128983 @default.
• W1999191657 cites W1984623782 @default.
• W1999191657 cites W1987929343 @default.
• W1999191657 cites W2016820258 @default.
• W1999191657 cites W2019242831 @default.
• W1999191657 cites W2040059820 @default.
• W1999191657 cites W2040659702 @default.
• W1999191657 cites W2045226853 @default.
• W1999191657 cites W2046244884 @default.
• W1999191657 cites W2047917369 @default.
• W1999191657 cites W2064397594 @default.
• W1999191657 cites W2077123850 @default.
• W1999191657 cites W2081625576 @default.
• W1999191657 cites W2085236183 @default.
• W1999191657 cites W2101822309 @default.
• W1999191657 cites W2102148490 @default.
• W1999191657 cites W2123517938 @default.
• W1999191657 cites W2129513982 @default.
• W1999191657 cites W2138693821 @default.
• W1999191657 cites W2141882258 @default.
• W1999191657 cites W2147923796 @default.
• W1999191657 cites W2148241719 @default.
• W1999191657 cites W2166779237 @default.
• W1999191657 cites W2168220641 @default.
• W1999191657 cites W2284965530 @default.
• W1999191657 cites W2320571739 @default.
• W1999191657 cites W2344220134 @default.
• W1999191657 doi "https://doi.org/10.1111/j.1469-7793.2000.t01-2-00593.x" @default.
• W1999191657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2269831" @default.
• W1999191657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10718740" @default.
• W1999191657 hasPublicationYear "2000" @default.
• W1999191657 type Work @default.
• W1999191657 sameAs 1999191657 @default.
• W1999191657 citedByCount "82" @default.
• W1999191657 countsByYear W19991916572012 @default.
• W1999191657 countsByYear W19991916572013 @default.
• W1999191657 countsByYear W19991916572014 @default.
• W1999191657 countsByYear W19991916572015 @default.
• W1999191657 countsByYear W19991916572016 @default.
• W1999191657 countsByYear W19991916572017 @default.
• W1999191657 countsByYear W19991916572018 @default.
• W1999191657 countsByYear W19991916572019 @default.
• W1999191657 countsByYear W19991916572020 @default.
• W1999191657 countsByYear W19991916572021 @default.
• W1999191657 countsByYear W19991916572022 @default.
• W1999191657 countsByYear W19991916572023 @default.
• W1999191657 crossrefType "journal-article" @default.
• W1999191657 hasAuthorship W1999191657A5074482591 @default.
• W1999191657 hasAuthorship W1999191657A5080062563 @default.
• W1999191657 hasAuthorship W1999191657A5087139089 @default.
• W1999191657 hasBestOaLocation W19991916572 @default.
• W1999191657 hasConcept C12554922 @default.
• W1999191657 hasConcept C126322002 @default.
• W1999191657 hasConcept C131453863 @default.
• W1999191657 hasConcept C147944092 @default.
• W1999191657 hasConcept C170493617 @default.
• W1999191657 hasConcept C177832589 @default.
• W1999191657 hasConcept C181911157 @default.
• W1999191657 hasConcept C185263204 @default.
• W1999191657 hasConcept C185592680 @default.
• W1999191657 hasConcept C197270303 @default.
• W1999191657 hasConcept C2777953023 @default.
• W1999191657 hasConcept C2778071365 @default.
• W1999191657 hasConcept C2778542873 @default.
• W1999191657 hasConcept C4141045 @default.
• W1999191657 hasConcept C50254741 @default.
• W1999191657 hasConcept C55493867 @default.
• W1999191657 hasConcept C66974803 @default.
• W1999191657 hasConcept C71240020 @default.
• W1999191657 hasConcept C71924100 @default.
• W1999191657 hasConcept C84393581 @default.
• W1999191657 hasConcept C86803240 @default.
• W1999191657 hasConcept C94924445 @default.
• W1999191657 hasConceptScore W1999191657C12554922 @default.
• W1999191657 hasConceptScore W1999191657C126322002 @default.
• W1999191657 hasConceptScore W1999191657C131453863 @default.
• W1999191657 hasConceptScore W1999191657C147944092 @default.
• W1999191657 hasConceptScore W1999191657C170493617 @default.
• W1999191657 hasConceptScore W1999191657C177832589 @default.
• W1999191657 hasConceptScore W1999191657C181911157 @default.
• W1999191657 hasConceptScore W1999191657C185263204 @default.
• W1999191657 hasConceptScore W1999191657C185592680 @default.
• W1999191657 hasConceptScore W1999191657C197270303 @default.
• W1999191657 hasConceptScore W1999191657C2777953023 @default.
• W1999191657 hasConceptScore W1999191657C2778071365 @default.

• next