FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999208965> ?p ?o ?g. }

• W1999208965 endingPage "e38615" @default.
• W1999208965 startingPage "e38615" @default.
• W1999208965 abstract "Background Non-obese diabetic (NOD) mice develop Sjögren's-like disease (SS-like) with loss of saliva flow and increased lymphocytic infiltrates in salivary glands (SGs). There are recent reports using multipotent mesenchymal stromal cells (MSCs) as a therapeutic strategy for autoimmune diseases due to their anti-inflammatory and immunomodulatory capabilities. This paper proposed a combined immuno- and cell-based therapy consisting of: A) an injection of complete Freund's adjuvant (CFA) to eradicate autoreactive T lymphocytes, and B) transplantations of MSCs to reselect lymphocytes. The objective of this was to test the effectiveness of CD45−/TER119− cells (MSCs) in re-establishing salivary function and in reducing the number of lymphocytic infiltrates (foci) in SGs. The second objective was to study if the mechanisms underlying a decrease in inflammation (focus score) was due to CFA, MSCs, or CFA+MSCs combined. Methodology/Principal Findings Donor MSCs were isolated from bones of male transgenic eGFP mice. Eight week-old female NOD mice received one of the following treatments: insulin, CFA, MSC, or CFA+MSC (combined therapy). Mice were followed for 14 weeks post-therapy. CD45−/TER119− cells demonstrated characteristics of MSCs as they were positive for Sca-1, CD106, CD105, CD73, CD29, CD44, negative for CD45, TER119, CD11b, had high number of CFU-F, and differentiated into osteocytes, chondrocytes and adipocytes. Both MSC and MSC+CFA groups prevented loss of saliva flow and reduced lymphocytic infiltrations in SGs. Moreover, the influx of T and B cells decreased in all foci in MSC and MSC+CFA groups, while the frequency of Foxp3+ (Treg) cell was increased. MSC-therapy alone reduced inflammation (TNF-α, TGF-β), but the combination of MSC+CFA reduced inflammation and increased the regenerative potential of SGs (FGF-2, EGF). Conclusions/Significance The combined use of MSC+CFA was effective in both preventing saliva secretion loss and reducing lymphocytic influx in salivary glands." @default.
• W1999208965 created "2016-06-24" @default.
• W1999208965 creator A5010327980 @default.
• W1999208965 creator A5033584209 @default.
• W1999208965 creator A5039121080 @default.
• W1999208965 creator A5058526750 @default.
• W1999208965 creator A5061775992 @default.
• W1999208965 creator A5072523216 @default.
• W1999208965 creator A5076613698 @default.
• W1999208965 creator A5087943806 @default.
• W1999208965 date "2012-06-07" @default.
• W1999208965 modified "2023-09-26" @default.
• W1999208965 title "Mesenchymal Stromal Cells Improve Salivary Function and Reduce Lymphocytic Infiltrates in Mice with Sjögren's-Like Disease" @default.
• W1999208965 cites W1594665449 @default.
• W1999208965 cites W1638726677 @default.
• W1999208965 cites W1694838020 @default.
• W1999208965 cites W1976496585 @default.
• W1999208965 cites W1978261658 @default.
• W1999208965 cites W1978425575 @default.
• W1999208965 cites W1981093904 @default.
• W1999208965 cites W1981622320 @default.
• W1999208965 cites W1981743114 @default.
• W1999208965 cites W1989500669 @default.
• W1999208965 cites W1999325485 @default.
• W1999208965 cites W2002726823 @default.
• W1999208965 cites W2007673642 @default.
• W1999208965 cites W2008477650 @default.
• W1999208965 cites W2021351302 @default.
• W1999208965 cites W2025371271 @default.
• W1999208965 cites W2029959553 @default.
• W1999208965 cites W2034675561 @default.
• W1999208965 cites W2039009609 @default.
• W1999208965 cites W2040713358 @default.
• W1999208965 cites W2048381117 @default.
• W1999208965 cites W2051208396 @default.
• W1999208965 cites W2051337941 @default.
• W1999208965 cites W2054393128 @default.
• W1999208965 cites W2057382222 @default.
• W1999208965 cites W2062695437 @default.
• W1999208965 cites W2066145942 @default.
• W1999208965 cites W2069239842 @default.
• W1999208965 cites W2085874330 @default.
• W1999208965 cites W2092211554 @default.
• W1999208965 cites W2092611780 @default.
• W1999208965 cites W2119774673 @default.
• W1999208965 cites W2122722718 @default.
• W1999208965 cites W2128404753 @default.
• W1999208965 cites W2134916694 @default.
• W1999208965 cites W2137308839 @default.
• W1999208965 cites W2151238232 @default.
• W1999208965 cites W2158461247 @default.
• W1999208965 cites W2171017604 @default.
• W1999208965 cites W2171417936 @default.
• W1999208965 cites W2217333307 @default.
• W1999208965 cites W3142959081 @default.
• W1999208965 doi "https://doi.org/10.1371/journal.pone.0038615" @default.
• W1999208965 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3369846" @default.
• W1999208965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22685592" @default.
• W1999208965 hasPublicationYear "2012" @default.
• W1999208965 type Work @default.
• W1999208965 sameAs 1999208965 @default.
• W1999208965 citedByCount "75" @default.
• W1999208965 countsByYear W19992089652013 @default.
• W1999208965 countsByYear W19992089652014 @default.
• W1999208965 countsByYear W19992089652015 @default.
• W1999208965 countsByYear W19992089652016 @default.
• W1999208965 countsByYear W19992089652017 @default.
• W1999208965 countsByYear W19992089652018 @default.
• W1999208965 countsByYear W19992089652019 @default.
• W1999208965 countsByYear W19992089652020 @default.
• W1999208965 countsByYear W19992089652021 @default.
• W1999208965 countsByYear W19992089652022 @default.
• W1999208965 countsByYear W19992089652023 @default.
• W1999208965 crossrefType "journal-article" @default.
• W1999208965 hasAuthorship W1999208965A5010327980 @default.
• W1999208965 hasAuthorship W1999208965A5033584209 @default.
• W1999208965 hasAuthorship W1999208965A5039121080 @default.
• W1999208965 hasAuthorship W1999208965A5058526750 @default.
• W1999208965 hasAuthorship W1999208965A5061775992 @default.
• W1999208965 hasAuthorship W1999208965A5072523216 @default.
• W1999208965 hasAuthorship W1999208965A5076613698 @default.
• W1999208965 hasAuthorship W1999208965A5087943806 @default.
• W1999208965 hasBestOaLocation W19992089651 @default.
• W1999208965 hasConcept C142724271 @default.
• W1999208965 hasConcept C16930146 @default.
• W1999208965 hasConcept C198826908 @default.
• W1999208965 hasConcept C203014093 @default.
• W1999208965 hasConcept C2778013207 @default.
• W1999208965 hasConcept C2780130043 @default.
• W1999208965 hasConcept C502942594 @default.
• W1999208965 hasConcept C71924100 @default.
• W1999208965 hasConcept C8891405 @default.
• W1999208965 hasConceptScore W1999208965C142724271 @default.
• W1999208965 hasConceptScore W1999208965C16930146 @default.
• W1999208965 hasConceptScore W1999208965C198826908 @default.
• W1999208965 hasConceptScore W1999208965C203014093 @default.
• W1999208965 hasConceptScore W1999208965C2778013207 @default.
• W1999208965 hasConceptScore W1999208965C2780130043 @default.

• next