FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999218784> ?p ?o ?g. }

• W1999218784 abstract "Changes to the cerebral white matter, observed as white matter hyperintensities (WMHs) on T2 or FLAIR MRI sequences, are extremely common in cognitively intact elderly. Those with increased baseline and rates of WMH accumulation have been shown to have an increased risk of conversion to mild cognitive impairment (MCI), a likely precursor of progressive dementia. The acceleration of this WMH increase relative to the time of the clinical transition to MCI has not been established. 184 subjects, mean age 83.8 ± 6.6, who transited to MCI in the Oregon Brain Aging Study during their follow-up were used in the current study. Subjects underwent annual cognitive and MRI assessments. MCI was defined by the first of two consecutive semiannual CDR scores > 0.5 to minimize the possible inclusion of subjects with transient or reversible cognitive impairment. WMH volumes were determined from T2 sequences using a semi-automated computer program. The outcome was % WMH out of intracranial volume. The time before MCI, when the change in WMH burden accelerates, was assessed using a mixed-effects model with a change point for subjects who developed MCI during follow-up of over 15 years (mean duration: 6.3 yrs ± 4.7), adjusting for age and gender. The presence of the following cerebrovascular risk factors was controlled in the models: stroke or transient ischemic attack, hypertension, diabetes, and smoking history. Acceleration in %WMH volume increase occurred 5.0 years (95% Confidence Interval: 2.8-10.5) before the onset of MCI. Before the change point, WMH increased by 0.49% annually (p< 0.0001), but after the change point, the increase accelerated by an additional 0.25% (p=0.001). That is, after the change point, WMH increased by 0.74% of ICV annually. Acceleration in CNS volume loss occurred 4.0 years (95% Confidence Interval: 3.2-5.0) before the onset of MCI. Acceleration in WMH burden (a common indicator of cerebrovascular disease in the elderly) is a pathological change that emerges early in the pre-symptomatic phase leading to MCI. Longitudinal changes in WMH may thus be useful in determining those at risk for cognitive impairment and for planning strategies for introducing disease modifying therapies prior to dementia onset." @default.
• W1999218784 created "2016-06-24" @default.
• W1999218784 creator A5012711937 @default.
• W1999218784 creator A5021979900 @default.
• W1999218784 creator A5022953237 @default.
• W1999218784 creator A5040631126 @default.
• W1999218784 creator A5087173048 @default.
• W1999218784 date "2011-07-01" @default.
• W1999218784 modified "2023-09-27" @default.
• W1999218784 title "IC-03-03: Trajectory of white matter hyperintensity burden preceding mild cognitive impairment" @default.
• W1999218784 doi "https://doi.org/10.1016/j.jalz.2011.05.015" @default.
• W1999218784 hasPublicationYear "2011" @default.
• W1999218784 type Work @default.
• W1999218784 sameAs 1999218784 @default.
• W1999218784 citedByCount "0" @default.
• W1999218784 crossrefType "journal-article" @default.
• W1999218784 hasAuthorship W1999218784A5012711937 @default.
• W1999218784 hasAuthorship W1999218784A5021979900 @default.
• W1999218784 hasAuthorship W1999218784A5022953237 @default.
• W1999218784 hasAuthorship W1999218784A5040631126 @default.
• W1999218784 hasAuthorship W1999218784A5087173048 @default.
• W1999218784 hasBestOaLocation W19992187841 @default.
• W1999218784 hasConcept C101070640 @default.
• W1999218784 hasConcept C126322002 @default.
• W1999218784 hasConcept C126838900 @default.
• W1999218784 hasConcept C143409427 @default.
• W1999218784 hasConcept C146638467 @default.
• W1999218784 hasConcept C164705383 @default.
• W1999218784 hasConcept C187212893 @default.
• W1999218784 hasConcept C2779134260 @default.
• W1999218784 hasConcept C2779483572 @default.
• W1999218784 hasConcept C2781192897 @default.
• W1999218784 hasConcept C2984863031 @default.
• W1999218784 hasConcept C2984915365 @default.
• W1999218784 hasConcept C44249647 @default.
• W1999218784 hasConcept C65835030 @default.
• W1999218784 hasConcept C71924100 @default.
• W1999218784 hasConceptScore W1999218784C101070640 @default.
• W1999218784 hasConceptScore W1999218784C126322002 @default.
• W1999218784 hasConceptScore W1999218784C126838900 @default.
• W1999218784 hasConceptScore W1999218784C143409427 @default.
• W1999218784 hasConceptScore W1999218784C146638467 @default.
• W1999218784 hasConceptScore W1999218784C164705383 @default.
• W1999218784 hasConceptScore W1999218784C187212893 @default.
• W1999218784 hasConceptScore W1999218784C2779134260 @default.
• W1999218784 hasConceptScore W1999218784C2779483572 @default.
• W1999218784 hasConceptScore W1999218784C2781192897 @default.
• W1999218784 hasConceptScore W1999218784C2984863031 @default.
• W1999218784 hasConceptScore W1999218784C2984915365 @default.
• W1999218784 hasConceptScore W1999218784C44249647 @default.
• W1999218784 hasConceptScore W1999218784C65835030 @default.
• W1999218784 hasConceptScore W1999218784C71924100 @default.
• W1999218784 hasIssue "4S_Part_1" @default.
• W1999218784 hasLocation W19992187841 @default.
• W1999218784 hasOpenAccess W1999218784 @default.
• W1999218784 hasPrimaryLocation W19992187841 @default.
• W1999218784 hasRelatedWork W1608409665 @default.
• W1999218784 hasRelatedWork W2030963269 @default.
• W1999218784 hasRelatedWork W2066936027 @default.
• W1999218784 hasRelatedWork W2070268750 @default.
• W1999218784 hasRelatedWork W2123220543 @default.
• W1999218784 hasRelatedWork W2128756004 @default.
• W1999218784 hasRelatedWork W2132874104 @default.
• W1999218784 hasRelatedWork W2342298207 @default.
• W1999218784 hasRelatedWork W2950570999 @default.
• W1999218784 hasRelatedWork W4317659503 @default.
• W1999218784 hasVolume "7" @default.
• W1999218784 isParatext "false" @default.
• W1999218784 isRetracted "false" @default.
• W1999218784 magId "1999218784" @default.
• W1999218784 workType "article" @default.