Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999223316> ?p ?o ?g. }
- W1999223316 endingPage "49" @default.
- W1999223316 startingPage "49" @default.
- W1999223316 abstract "Acute lymphoblastic leukemia in adolescents and young adults – from genomics to the clinics Saad Sirop Kenderian, Mark R Litzow Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA Abstract: Acute lymphoblastic leukemia (ALL) in adolescents and young adults (AYA) represents a unique and challenging disease entity. Despite the recent improvement of survival in this population over the last decade, it is still lagging behind the excellent cure rates obtained in pediatric ALL. This special population of AYA receives care from pediatric as well as adult hematologists and can be treated on pediatric or adult protocols. There is a substantial difference in disease biology, response to chemotherapy, and allogeneic stem cell transplantation between pediatric and AYA patients. This review discusses current controversies in the management of AYA, outcomes following treatment with pediatric and adult protocols, and the role of allogeneic stem cell transplantation. It focuses on the unique clinical, biological, and socioeconomic characteristics of this population that might partly explain the inferior outcomes. This review also explores recent advances in genomic profiling and emerging treatments in ALL. Keywords: novel agents, monoclonal antibodies, stem cell transplantation, bone marrow transplantation, Philadelphia positive ALL, genomic profile" @default.
- W1999223316 created "2016-06-24" @default.
- W1999223316 creator A5054196868 @default.
- W1999223316 creator A5085360755 @default.
- W1999223316 date "2013-04-01" @default.
- W1999223316 modified "2023-10-17" @default.
- W1999223316 title "Acute lymphoblastic leukemia in adolescents and young adults – from genomics to the clinics" @default.
- W1999223316 cites W146900568 @default.
- W1999223316 cites W1966375226 @default.
- W1999223316 cites W1971939163 @default.
- W1999223316 cites W1974345467 @default.
- W1999223316 cites W1975280591 @default.
- W1999223316 cites W1977546984 @default.
- W1999223316 cites W1980247257 @default.
- W1999223316 cites W1981353115 @default.
- W1999223316 cites W1981459448 @default.
- W1999223316 cites W1984684983 @default.
- W1999223316 cites W1986288031 @default.
- W1999223316 cites W1987294127 @default.
- W1999223316 cites W1991343198 @default.
- W1999223316 cites W1991644988 @default.
- W1999223316 cites W1993808217 @default.
- W1999223316 cites W1994568187 @default.
- W1999223316 cites W1999976747 @default.
- W1999223316 cites W2000116184 @default.
- W1999223316 cites W2010729137 @default.
- W1999223316 cites W2012114257 @default.
- W1999223316 cites W2016648625 @default.
- W1999223316 cites W2017838975 @default.
- W1999223316 cites W2018874316 @default.
- W1999223316 cites W2019386151 @default.
- W1999223316 cites W2026698098 @default.
- W1999223316 cites W2027763899 @default.
- W1999223316 cites W2031836130 @default.
- W1999223316 cites W2034099754 @default.
- W1999223316 cites W2035343180 @default.
- W1999223316 cites W2037148599 @default.
- W1999223316 cites W2038613090 @default.
- W1999223316 cites W2040329520 @default.
- W1999223316 cites W2043587224 @default.
- W1999223316 cites W2046838777 @default.
- W1999223316 cites W2052336881 @default.
- W1999223316 cites W2053218407 @default.
- W1999223316 cites W2061585822 @default.
- W1999223316 cites W2064184441 @default.
- W1999223316 cites W2066064966 @default.
- W1999223316 cites W2069709802 @default.
- W1999223316 cites W2071700698 @default.
- W1999223316 cites W2073240116 @default.
- W1999223316 cites W2092369026 @default.
- W1999223316 cites W2094546718 @default.
- W1999223316 cites W2097373767 @default.
- W1999223316 cites W2097827598 @default.
- W1999223316 cites W2100725347 @default.
- W1999223316 cites W2102929198 @default.
- W1999223316 cites W2104694028 @default.
- W1999223316 cites W2106275447 @default.
- W1999223316 cites W2108008366 @default.
- W1999223316 cites W2110013351 @default.
- W1999223316 cites W2110108440 @default.
- W1999223316 cites W2110993734 @default.
- W1999223316 cites W2117823975 @default.
- W1999223316 cites W2118597842 @default.
- W1999223316 cites W2119323978 @default.
- W1999223316 cites W2119967034 @default.
- W1999223316 cites W2120104555 @default.
- W1999223316 cites W2123755151 @default.
- W1999223316 cites W2127742735 @default.
- W1999223316 cites W2129315771 @default.
- W1999223316 cites W2130003099 @default.
- W1999223316 cites W2135563540 @default.
- W1999223316 cites W2139499066 @default.
- W1999223316 cites W2139969490 @default.
- W1999223316 cites W2142226489 @default.
- W1999223316 cites W2145662640 @default.
- W1999223316 cites W2145968395 @default.
- W1999223316 cites W2146762986 @default.
- W1999223316 cites W2147076142 @default.
- W1999223316 cites W2150368697 @default.
- W1999223316 cites W2151288624 @default.
- W1999223316 cites W2156671071 @default.
- W1999223316 cites W2157627970 @default.
- W1999223316 cites W2160881482 @default.
- W1999223316 cites W2164574990 @default.
- W1999223316 cites W2166306614 @default.
- W1999223316 cites W2167548316 @default.
- W1999223316 cites W2176249198 @default.
- W1999223316 cites W2276967310 @default.
- W1999223316 cites W2409145706 @default.
- W1999223316 cites W2460477750 @default.
- W1999223316 cites W2558541011 @default.
- W1999223316 cites W2560119857 @default.
- W1999223316 cites W2563838629 @default.
- W1999223316 cites W2564019916 @default.
- W1999223316 cites W2564031428 @default.
- W1999223316 cites W2564706358 @default.
- W1999223316 cites W2564933750 @default.
- W1999223316 cites W2571322992 @default.