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• W1999241036 startingPage "195" @default.
• W1999241036 abstract "Prolactin (PRL) is widely considered to be the juvenile hormone of anuran tadpoles and to counteract the effects of thyroid hormone (TH), the hormone that controls amphibian metamorphosis. This putative function was concluded mainly from experiments in which mammalian PRL was injected into tadpoles or added to cultured tadpole tissues. In this study, we show that overexpression of ovine or Xenopus laevis PRL in transgenic X. laevis does not prolong tadpole life, establishing that PRL does not play a role in the life cycle of amphibians that is equivalent to that of juvenile hormone in insect metamorphosis. However, overexpression of PRL produces tailed frogs by reversing specifically some but not all of the programs of tail resorption and stimulating growth of fibroblasts in the tail. Whereas TH induces muscle resorption in tails of these transgenics, the tail fibroblasts continue to proliferate resulting in a fibrotic tail that is resistant to TH." @default.
• W1999241036 created "2016-06-24" @default.
• W1999241036 creator A5013917487 @default.
• W1999241036 creator A5019609294 @default.
• W1999241036 date "2000-01-04" @default.
• W1999241036 modified "2023-10-03" @default.
• W1999241036 title "Prolactin is not a juvenile hormone in <i>Xenopus</i> <i>laevis</i> metamorphosis" @default.
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• W1999241036 doi "https://doi.org/10.1073/pnas.97.1.195" @default.
• W1999241036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/26639" @default.
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• W1999241036 hasPublicationYear "2000" @default.
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