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- W1999241498 abstract "Abstract A series of C5 cycloalkyl benzodiazepin-2-one CCKB receptor antagonists are reported in which substitution by tolyl-urea at C3 has generated a chiral centre. As only one of these enantiomers is selective for the CCKB receptor an analytical separation of the enantiomers was developed to monitor the resolution of compounds by chemical means. It was shown that such compounds may be resolved using a Pirkle-type 3,5-(dinitrobenzoyl)-leucine (DNBL) chiral stationary phase (CSP) to give high a and Rs values. Such high enantioselectivities allowed the separation to be scaled-up sufficiently such that gram quantities of each enantiomer could be isolated by preparative chiral HPLC. An investigation is described in which the effect of substituent, mobile phase composition, temperature and the alternate CSP 3,5-(dinitrobenzoyl)-phenylglycine (DNPBG) is discussed for such compounds." @default.
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- W1999241498 date "1997-01-01" @default.
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- W1999241498 title "Analytical and Preparative Enantiomeric Separation of a Series of C5-Cycloalkylamine-L,4-Benzodiazepin-2-one CCKB Receptor Antagonists by Chiral HPLC" @default.
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- W1999241498 doi "https://doi.org/10.1080/10826079708010640" @default.
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