FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999248384> ?p ?o ?g. }

• W1999248384 endingPage "C849" @default.
• W1999248384 startingPage "C841" @default.
• W1999248384 abstract "Sarcolipin (SLN) inhibits sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pumps. To evaluate the physiological significance of SLN in skeletal muscle, we compared muscle contractility and SERCA activity between Sln-null and wild-type mice. SLN protein expression in wild-type mice was abundant in soleus and red gastrocnemius (RG), low in extensor digitorum longus (EDL), and absent from white gastrocnemius (WG). SERCA activity rates were increased in soleus and RG, but not in EDL or WG, from Sln-null muscles, compared with wild type. No differences were seen between wild-type and Sln-null EDL muscles in force-frequency curves or maximum rates of force development (+dF/dt). Maximum relaxation rates (-dF/dt) of EDL were higher in Sln-null than wild type across a range of submaximal stimulation frequencies, but not during a twitch or peak tetanic contraction. For soleus, no differences were seen between wild type and Sln-null in peak tetanic force or +dF/dt; however, force-frequency curves showed that peak force during a twitch and 10-Hz contraction was lower in Sln-null. Changes in the soleus force-frequency curve corresponded with faster rates of force relaxation at nearly all stimulation frequencies in Sln-null compared with wild type. Repeated tetanic stimulation of soleus caused increased (-dF/dt) in wild type, but not in Sln-null. No compensatory responses were detected in analysis of other Ca(2+) regulatory proteins using Western blotting and immunohistochemistry or myosin heavy chain expression using immunofluorescence. These results show that 1) SLN regulates Ca(2+)-ATPase activity thereby regulating contractile kinetics in at least some skeletal muscles, 2) the functional significance of SLN is graded to the endogenous SLN expression level, and 3) SLN inhibitory effects on SERCA function are relieved in response to repeated contractions thus enhancing relaxation rates." @default.
• W1999248384 created "2016-06-24" @default.
• W1999248384 creator A5013877671 @default.
• W1999248384 creator A5019463364 @default.
• W1999248384 creator A5021487747 @default.
• W1999248384 creator A5032514627 @default.
• W1999248384 creator A5037914587 @default.
• W1999248384 creator A5041040281 @default.
• W1999248384 creator A5041105609 @default.
• W1999248384 creator A5045991393 @default.
• W1999248384 creator A5047489962 @default.
• W1999248384 creator A5057847031 @default.
• W1999248384 creator A5064079361 @default.
• W1999248384 creator A5068839871 @default.
• W1999248384 creator A5085059825 @default.
• W1999248384 date "2011-10-01" @default.
• W1999248384 modified "2023-10-04" @default.
• W1999248384 title "Enhanced Ca²⁺ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice" @default.
• W1999248384 cites W1969326155 @default.
• W1999248384 cites W1975535705 @default.
• W1999248384 cites W2003233440 @default.
• W1999248384 cites W2006482606 @default.
• W1999248384 cites W2009910222 @default.
• W1999248384 cites W2031301713 @default.
• W1999248384 cites W2032245659 @default.
• W1999248384 cites W2034931158 @default.
• W1999248384 cites W2035006932 @default.
• W1999248384 cites W2036181485 @default.
• W1999248384 cites W2038499885 @default.
• W1999248384 cites W2056507591 @default.
• W1999248384 cites W2060374317 @default.
• W1999248384 cites W2061688246 @default.
• W1999248384 cites W2065650877 @default.
• W1999248384 cites W2071160031 @default.
• W1999248384 cites W2075097463 @default.
• W1999248384 cites W2075211949 @default.
• W1999248384 cites W2096759707 @default.
• W1999248384 cites W2103647634 @default.
• W1999248384 cites W2104601678 @default.
• W1999248384 cites W2104874788 @default.
• W1999248384 cites W2106447491 @default.
• W1999248384 cites W2108172458 @default.
• W1999248384 cites W2111809871 @default.
• W1999248384 cites W2132520315 @default.
• W1999248384 cites W2142754357 @default.
• W1999248384 cites W2146432584 @default.
• W1999248384 cites W2147329907 @default.
• W1999248384 cites W2149199989 @default.
• W1999248384 cites W2157325454 @default.
• W1999248384 cites W2161336300 @default.
• W1999248384 cites W2166246053 @default.
• W1999248384 cites W2169093265 @default.
• W1999248384 cites W2182383789 @default.
• W1999248384 cites W2264443444 @default.
• W1999248384 cites W2792980560 @default.
• W1999248384 cites W58055601 @default.
• W1999248384 doi "https://doi.org/10.1152/ajpcell.00409.2010" @default.
• W1999248384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3654932" @default.
• W1999248384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21697544" @default.
• W1999248384 hasPublicationYear "2011" @default.
• W1999248384 type Work @default.
• W1999248384 sameAs 1999248384 @default.
• W1999248384 citedByCount "68" @default.
• W1999248384 countsByYear W19992483842012 @default.
• W1999248384 countsByYear W19992483842013 @default.
• W1999248384 countsByYear W19992483842014 @default.
• W1999248384 countsByYear W19992483842015 @default.
• W1999248384 countsByYear W19992483842016 @default.
• W1999248384 countsByYear W19992483842017 @default.
• W1999248384 countsByYear W19992483842018 @default.
• W1999248384 countsByYear W19992483842019 @default.
• W1999248384 countsByYear W19992483842020 @default.
• W1999248384 countsByYear W19992483842021 @default.
• W1999248384 countsByYear W19992483842022 @default.
• W1999248384 countsByYear W19992483842023 @default.
• W1999248384 crossrefType "journal-article" @default.
• W1999248384 hasAuthorship W1999248384A5013877671 @default.
• W1999248384 hasAuthorship W1999248384A5019463364 @default.
• W1999248384 hasAuthorship W1999248384A5021487747 @default.
• W1999248384 hasAuthorship W1999248384A5032514627 @default.
• W1999248384 hasAuthorship W1999248384A5037914587 @default.
• W1999248384 hasAuthorship W1999248384A5041040281 @default.
• W1999248384 hasAuthorship W1999248384A5041105609 @default.
• W1999248384 hasAuthorship W1999248384A5045991393 @default.
• W1999248384 hasAuthorship W1999248384A5047489962 @default.
• W1999248384 hasAuthorship W1999248384A5057847031 @default.
• W1999248384 hasAuthorship W1999248384A5064079361 @default.
• W1999248384 hasAuthorship W1999248384A5068839871 @default.
• W1999248384 hasAuthorship W1999248384A5085059825 @default.
• W1999248384 hasBestOaLocation W19992483842 @default.
• W1999248384 hasConcept C12554922 @default.
• W1999248384 hasConcept C126322002 @default.
• W1999248384 hasConcept C134018914 @default.
• W1999248384 hasConcept C163415756 @default.
• W1999248384 hasConcept C170493617 @default.
• W1999248384 hasConcept C181199279 @default.
• W1999248384 hasConcept C185592680 @default.
• W1999248384 hasConcept C200170125 @default.

• next