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- W1999270110 abstract "posed of mtDNA and formylated peptides, are released after cellular injury and activate innate immune responses.mtDNA is found in variable amounts in serumand the tumormicroenvironment of epithelial ovarian cancer (EOC) patients. Because EOC is associated with cellular necrosis, we reasoned that extracellular mtDNA may be a molecular marker of prognosis. The prognostic significance of CA-125, the serummarkermost closely associated with EOC, is widely published. Methods: Serum frompatientswith advanced-stage EOC collected before primary surgical debulking (n= 41) was analyzed for mtDNA using quantitative polymerase chain reaction with cytochrome B primers specific for mtDNA. Defining the top 15% concentration of serum mtDNA as the high (hi) category and the remainder as low (lo), survival was determined for each category. Comparison using Cox regression model was performed. Progression-free survival (PFS) was the primary clinical endpoint. Log rank test was then used to correlate published CA-125 data with serum mtDNA. Results: Patientswithin the serummtDNA grouphadmarkedly reduced PFS (4.5 vs. 16.1 months; P=0.00145) and overall survival (8.3 vs. 50.1 months; P=0.00098) compared to the mtDNA group. Table 1A lists the patient characteristics, including disease stage, histology, grade, and mean patient age at diagnosis. Comparing pretreatment serum mtDNA levels to published results on serum CA-125 levels from a Gynecology Oncology Group study that analyzed 1299 patientswith EOC, serum mtDNA was substantially better in predicting prognosis for PFS (HR= 4.3) and OS (HR= 5.4), as shown in Table 1B. Conclusions: Comparing pretreatment serum mtDNA levels in a small cohort of the top 15% with published data on serum CA-125 levels, we observed significantly greater effect sizes with serum mtDNA in predicting prognosis in EOC, with the greatest effect in the high serum mtDNA category." @default.
- W1999270110 created "2016-06-24" @default.
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- W1999270110 date "2015-04-01" @default.
- W1999270110 modified "2023-09-22" @default.
- W1999270110 title "Laparoscopic retroperitoneal lymphadenectomy for bulky para-aortic ovarian cancer recurrence" @default.
- W1999270110 doi "https://doi.org/10.1016/j.ygyno.2015.01.030" @default.
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