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- W1999275462 abstract "Influenza viruses are serious pathogens for humans. They are known to infect host tissues by first binding to sialoconjugates on the cell surface through their hemagglutinin. α-Sialoside-containing polymers have been demonstrated to be potent inhibitors of the hemagglutination on human erythrocytes by influenza viruses. Moreover, they have showed superior antigenic properties than their corresponding natural sialoconjugates from the basis of multivalent and cluster effects. For the viewpoint of drug targeting, we have tried to develop efficient synthesis of novel sialopolymers in which the inter-sialoside distances could be controlled. We report the novel synthesis of sialocopolymers using condensation polymerization. The condensation of branched α-sialoside, prepared from p-nitrophenyl α-sialoside and 3,3′-iminobis(propylamine) with 1,4-diisocyanatobutane and 1,6-diisocyanatohexane, produced copolymers without any promoters. These copolymers retained their specific lectin-binding properties, as determined with wheat germ agglutinin (WGA), a plant lectin known to bind sialosides and glucosaminides on the agar gel double immunodiffusion test. Each copolymer showed clear binding. On micro-turbidimetric assay, they exhibited strong cross-linking properties with WGA, and copolymer including the hexyl group showed stronger binding properties than the butyl one." @default.
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- W1999275462 date "2001-12-01" @default.
- W1999275462 modified "2023-09-28" @default.
- W1999275462 title "Synthesis of novel sialic acid-containing polymers as inhibitors of hemagglutination" @default.
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- W1999275462 doi "https://doi.org/10.1016/s0531-5131(01)00428-9" @default.
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