FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999276095> ?p ?o ?g. }

• W1999276095 endingPage "374" @default.
• W1999276095 startingPage "363" @default.
• W1999276095 abstract "Splenic macrophages play a key role in regulating cell proliferation during a variety of chronic perturbations of the hematopoietic system. This regulatory activity is in sharp contrast to the activities of inflammatory monocytes/macrophages in that it is not dominated by the secretion of prostaglandins or toxic metabolites such as peroxides. A productive model for studying these nontoxic regulatory activities of splenic macrophages has been provided by macrophages generated in vitro (Mø-c) during autologous spleen cell culture. The Mø-c effectively inhibit (>90%) lymphocyte proliferation by inhibiting G1→S phase progression without inhibiting the production of interleukins by the lymphocytes. Conditioned medium from Mø-c activated with LPS + rIFN-γ effected a similar G1 arrest of activated lymphocytes. The involvement of IFN-β in effecting the antiproliferative activity is suggested by (1) the ability of monospecific anti-IFN-β mAB, but not anti-TGF-β, anti-IL-1, anti-TNF-α, or anti-IFN-γ, to neutralize the antiproliferative activity in the Mø-c supernatants and (2) the ability of purified IFN-β to effect a similar inhibition of cell proliferation (i.e., G1 arrest without inhibition of interleukin production). rTNF-α and rIFN-γ could not effect such an inhibition of cell proliferation and did not synergize with IFN-β in producing such an antiproliferative effect. The Mø-c could be activated to effector function by a combination of LPS + rIFN-γ or rTNF-α + rIFN-γ, but not by any one of those reagents alone. LPS alone was sufficient to stimulate TNF-α production by the Mø-c. Activation of the Mø)-c by LPS + rIFN-γ could be completely blocked by anti-TNF-a antibodies. These data suggest that the Mø-c can be induced to produce inhibitory levels of cytostatic cytokines by a TNF-α autocrine loop that is IFN-γ dependent. The in vivo relevance of this effector mechanism is suggested by, and discussed in the context of, the recent reports of “spontaneous” production of IFN-β during immunological disorders." @default.
• W1999276095 created "2016-06-24" @default.
• W1999276095 creator A5056061479 @default.
• W1999276095 creator A5076113010 @default.
• W1999276095 date "1992-02-01" @default.
• W1999276095 modified "2023-09-27" @default.
• W1999276095 title "Evidence for involvement of TNF-α in the induction phase and IFN-β in the effector phase of antiproliferative activity of splenic macrophages" @default.
• W1999276095 cites W1523531414 @default.
• W1999276095 cites W1534274816 @default.
• W1999276095 cites W1536939386 @default.
• W1999276095 cites W1552812763 @default.
• W1999276095 cites W1558675846 @default.
• W1999276095 cites W1559795580 @default.
• W1999276095 cites W1560190801 @default.
• W1999276095 cites W1562311277 @default.
• W1999276095 cites W1566302510 @default.
• W1999276095 cites W1567468635 @default.
• W1999276095 cites W1600496839 @default.
• W1999276095 cites W1897226866 @default.
• W1999276095 cites W1920825587 @default.
• W1999276095 cites W1942668068 @default.
• W1999276095 cites W1964174689 @default.
• W1999276095 cites W1972521500 @default.
• W1999276095 cites W1976865493 @default.
• W1999276095 cites W1980514400 @default.
• W1999276095 cites W1986193266 @default.
• W1999276095 cites W1986939367 @default.
• W1999276095 cites W2007768242 @default.
• W1999276095 cites W2009788307 @default.
• W1999276095 cites W2013665821 @default.
• W1999276095 cites W2014426420 @default.
• W1999276095 cites W2015004821 @default.
• W1999276095 cites W2017596457 @default.
• W1999276095 cites W2033684442 @default.
• W1999276095 cites W2046196550 @default.
• W1999276095 cites W2050820037 @default.
• W1999276095 cites W2077308166 @default.
• W1999276095 cites W2083726090 @default.
• W1999276095 cites W2102349493 @default.
• W1999276095 cites W2131115069 @default.
• W1999276095 cites W2159069239 @default.
• W1999276095 cites W2172845396 @default.
• W1999276095 cites W2174322658 @default.
• W1999276095 cites W4231432207 @default.
• W1999276095 cites W4236236434 @default.
• W1999276095 doi "https://doi.org/10.1016/0008-8749(92)90078-4" @default.
• W1999276095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1733508" @default.
• W1999276095 hasPublicationYear "1992" @default.
• W1999276095 type Work @default.
• W1999276095 sameAs 1999276095 @default.
• W1999276095 citedByCount "12" @default.
• W1999276095 crossrefType "journal-article" @default.
• W1999276095 hasAuthorship W1999276095A5056061479 @default.
• W1999276095 hasAuthorship W1999276095A5076113010 @default.
• W1999276095 hasConcept C134018914 @default.
• W1999276095 hasConcept C17991360 @default.
• W1999276095 hasConcept C202751555 @default.
• W1999276095 hasConcept C203014093 @default.
• W1999276095 hasConcept C2778690821 @default.
• W1999276095 hasConcept C2779244956 @default.
• W1999276095 hasConcept C2780931953 @default.
• W1999276095 hasConcept C49039625 @default.
• W1999276095 hasConcept C51785407 @default.
• W1999276095 hasConcept C55493867 @default.
• W1999276095 hasConcept C62112901 @default.
• W1999276095 hasConcept C86803240 @default.
• W1999276095 hasConceptScore W1999276095C134018914 @default.
• W1999276095 hasConceptScore W1999276095C17991360 @default.
• W1999276095 hasConceptScore W1999276095C202751555 @default.
• W1999276095 hasConceptScore W1999276095C203014093 @default.
• W1999276095 hasConceptScore W1999276095C2778690821 @default.
• W1999276095 hasConceptScore W1999276095C2779244956 @default.
• W1999276095 hasConceptScore W1999276095C2780931953 @default.
• W1999276095 hasConceptScore W1999276095C49039625 @default.
• W1999276095 hasConceptScore W1999276095C51785407 @default.
• W1999276095 hasConceptScore W1999276095C55493867 @default.
• W1999276095 hasConceptScore W1999276095C62112901 @default.
• W1999276095 hasConceptScore W1999276095C86803240 @default.
• W1999276095 hasIssue "2" @default.
• W1999276095 hasLocation W19992760951 @default.
• W1999276095 hasLocation W19992760952 @default.
• W1999276095 hasOpenAccess W1999276095 @default.
• W1999276095 hasPrimaryLocation W19992760951 @default.
• W1999276095 hasRelatedWork W1994050787 @default.
• W1999276095 hasRelatedWork W2015459546 @default.
• W1999276095 hasRelatedWork W2105418996 @default.
• W1999276095 hasRelatedWork W2115251431 @default.
• W1999276095 hasRelatedWork W2347684119 @default.
• W1999276095 hasRelatedWork W2378618357 @default.
• W1999276095 hasRelatedWork W2384242661 @default.
• W1999276095 hasRelatedWork W2398878426 @default.
• W1999276095 hasRelatedWork W2409988542 @default.
• W1999276095 hasRelatedWork W591945087 @default.
• W1999276095 hasVolume "139" @default.
• W1999276095 isParatext "false" @default.
• W1999276095 isRetracted "false" @default.
• W1999276095 magId "1999276095" @default.
• W1999276095 workType "article" @default.