FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999278327> ?p ?o ?g. }

• W1999278327 endingPage "26" @default.
• W1999278327 startingPage "21" @default.
• W1999278327 abstract "PI3K/AKT signalling pathway controls important cellular processes such as the cell proliferation and apoptosis. PIK3CA gene encoding a catalytic subunit of the PI3K is mutated and/or amplified in various neoplasms, including ovarian cancer. We aimed to evaluate PIK3CA alterations and their clinical importance in ovarian cancer patients. Molecular analysis was performed on 117 ovarian carcinomas with the use of qPCR, SSCP and sequencing. In a group of 98 patients with complete clinical data, 62 patients were treated with standard taxane-platinum regimens and 36 patients with platinum-cyclophosphamide regimens. A multivariate analysis was performed by the Cox's and logistic regression models. PIK3CA mutations occurred in 5/117 (4.3%) carcinomas, exclusively in the endometrioid and clear cell types (p = 0.0002); they were also associated with low FIGO stage (p = 0.0003), low tumor grade (p = 0.045) and early patient's age at diagnosis (p = 0.0005). The PIK3CA amplification (predominantly a low-level) was found in 28/117 (24%) ovarian carcinomas. It was more frequent in TP53 mutant tumors (p = 0.012) and tended to associate with high pAKT expression (p = 0.061). The PIK3CA amplification strongly diminished odds of complete remission (OR = 0.25, p = 0.033) and platinum sensitive response (PS, OR = 0.12, p = 0.004) in the taxane-platinum treated patients. The odds of PS were also much lower in all patients with the PIK3CA amplification evaluated together, regardless of the treatment applied (OR = 0.18, p = 0.001). Our results suggest that PIK3CA amplification may be a marker predicting ovarian cancer response to chemotherapy." @default.
• W1999278327 created "2016-06-24" @default.
• W1999278327 creator A5016847201 @default.
• W1999278327 creator A5030601366 @default.
• W1999278327 creator A5036076289 @default.
• W1999278327 creator A5038574935 @default.
• W1999278327 creator A5051561067 @default.
• W1999278327 creator A5055353827 @default.
• W1999278327 creator A5061423783 @default.
• W1999278327 creator A5075651552 @default.
• W1999278327 creator A5078714257 @default.
• W1999278327 date "2009-01-01" @default.
• W1999278327 modified "2023-10-10" @default.
• W1999278327 title "PIK3CA amplification associates with resistance to chemotherapy in ovarian cancer patients" @default.
• W1999278327 cites W140268124 @default.
• W1999278327 cites W1505255521 @default.
• W1999278327 cites W1537889906 @default.
• W1999278327 cites W1545893705 @default.
• W1999278327 cites W1594020010 @default.
• W1999278327 cites W1912261041 @default.
• W1999278327 cites W1970131592 @default.
• W1999278327 cites W1971843650 @default.
• W1999278327 cites W1981219604 @default.
• W1999278327 cites W1987328581 @default.
• W1999278327 cites W1991384876 @default.
• W1999278327 cites W1999065747 @default.
• W1999278327 cites W2014031706 @default.
• W1999278327 cites W2016503230 @default.
• W1999278327 cites W2031594903 @default.
• W1999278327 cites W2032720638 @default.
• W1999278327 cites W2032974786 @default.
• W1999278327 cites W2036093957 @default.
• W1999278327 cites W2040140279 @default.
• W1999278327 cites W2044464259 @default.
• W1999278327 cites W2053521827 @default.
• W1999278327 cites W2062185937 @default.
• W1999278327 cites W2081994535 @default.
• W1999278327 cites W2100470338 @default.
• W1999278327 cites W2106770132 @default.
• W1999278327 cites W2109528706 @default.
• W1999278327 cites W2127281537 @default.
• W1999278327 cites W2137714688 @default.
• W1999278327 cites W2144040817 @default.
• W1999278327 cites W2154692501 @default.
• W1999278327 cites W2154893943 @default.
• W1999278327 cites W2155197934 @default.
• W1999278327 cites W2167010784 @default.
• W1999278327 cites W2167805334 @default.
• W1999278327 cites W2404556245 @default.
• W1999278327 cites W2413490488 @default.
• W1999278327 doi "https://doi.org/10.4161/cbt.8.1.7209" @default.
• W1999278327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19029838" @default.
• W1999278327 hasPublicationYear "2009" @default.
• W1999278327 type Work @default.
• W1999278327 sameAs 1999278327 @default.
• W1999278327 citedByCount "85" @default.
• W1999278327 countsByYear W19992783272012 @default.
• W1999278327 countsByYear W19992783272013 @default.
• W1999278327 countsByYear W19992783272014 @default.
• W1999278327 countsByYear W19992783272015 @default.
• W1999278327 countsByYear W19992783272016 @default.
• W1999278327 countsByYear W19992783272017 @default.
• W1999278327 countsByYear W19992783272018 @default.
• W1999278327 countsByYear W19992783272019 @default.
• W1999278327 countsByYear W19992783272020 @default.
• W1999278327 countsByYear W19992783272021 @default.
• W1999278327 countsByYear W19992783272022 @default.
• W1999278327 crossrefType "journal-article" @default.
• W1999278327 hasAuthorship W1999278327A5016847201 @default.
• W1999278327 hasAuthorship W1999278327A5030601366 @default.
• W1999278327 hasAuthorship W1999278327A5036076289 @default.
• W1999278327 hasAuthorship W1999278327A5038574935 @default.
• W1999278327 hasAuthorship W1999278327A5051561067 @default.
• W1999278327 hasAuthorship W1999278327A5055353827 @default.
• W1999278327 hasAuthorship W1999278327A5061423783 @default.
• W1999278327 hasAuthorship W1999278327A5075651552 @default.
• W1999278327 hasAuthorship W1999278327A5078714257 @default.
• W1999278327 hasBestOaLocation W19992783271 @default.
• W1999278327 hasConcept C121608353 @default.
• W1999278327 hasConcept C126322002 @default.
• W1999278327 hasConcept C143998085 @default.
• W1999278327 hasConcept C156957248 @default.
• W1999278327 hasConcept C190283241 @default.
• W1999278327 hasConcept C2776694085 @default.
• W1999278327 hasConcept C2777511904 @default.
• W1999278327 hasConcept C2777609662 @default.
• W1999278327 hasConcept C2780427987 @default.
• W1999278327 hasConcept C502942594 @default.
• W1999278327 hasConcept C530470458 @default.
• W1999278327 hasConcept C54355233 @default.
• W1999278327 hasConcept C71924100 @default.
• W1999278327 hasConcept C86554907 @default.
• W1999278327 hasConcept C86803240 @default.
• W1999278327 hasConceptScore W1999278327C121608353 @default.
• W1999278327 hasConceptScore W1999278327C126322002 @default.
• W1999278327 hasConceptScore W1999278327C143998085 @default.
• W1999278327 hasConceptScore W1999278327C156957248 @default.
• W1999278327 hasConceptScore W1999278327C190283241 @default.

• next