Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999278370> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1999278370 endingPage "1314" @default.
- W1999278370 startingPage "1310" @default.
- W1999278370 abstract "Bicalutamide is a non-steroidal antiandrogen and is an oral medication that is used for treating prostate cancer. To evaluate the bioavailability of bicalutamide from bicalutamide self-microemulsifying drug delivery systems (SMEDDS) and bicalutamide suspension formulations, a sensitive, specific reversed-phase high performance liquid chromatographic (HPLC) method using ultraviolet detection was developed and validated for the analysis of bicalutamide (BCT) in rat blood plasma. Letrozole (LZ) was used as the internal standard. The chromatographic separation was achieved on C18 column at 35 °C, with a mobile phase consisting of water: acetonitrile (adjusted to pH 3.0 with 20% o-phosphoric acid) (60:40), at a flow rate of 1.0 mL min−1. Bicalutamide and letrozole were well separated with retention times of 10.9 ± 0.2 and 5.7 ± 0.2 min, respectively. The method was successfully used to determine pharmacokinetics of bicalutamide, following oral administration of bicalutamide suspension and bicalutamide SMEDDS to wistar rats. Significant difference was observed in main pharmacokinetic parameters of tmax, Cmax and AUC0→∞ between SMEDDS and suspension, and a two fold increase in the relative bioavailability of bicalutamide was observed with the SMEDDS compared with suspension formulation. It was concluded that the absorption of bicalutamide from SMEDDS was enhanced." @default.
- W1999278370 created "2016-06-24" @default.
- W1999278370 creator A5003374144 @default.
- W1999278370 creator A5015679073 @default.
- W1999278370 creator A5035241559 @default.
- W1999278370 creator A5045777007 @default.
- W1999278370 creator A5062167921 @default.
- W1999278370 creator A5071782352 @default.
- W1999278370 creator A5081815617 @default.
- W1999278370 creator A5083786936 @default.
- W1999278370 date "2009-06-15" @default.
- W1999278370 modified "2023-10-17" @default.
- W1999278370 title "High performance liquid chromatography method for the pharmacokinetic study of bicalutamide SMEDDS and suspension formulations after oral administration to rats" @default.
- W1999278370 cites W1780471582 @default.
- W1999278370 cites W1975441908 @default.
- W1999278370 cites W1976061403 @default.
- W1999278370 cites W1979791843 @default.
- W1999278370 cites W1993481388 @default.
- W1999278370 cites W1994183479 @default.
- W1999278370 cites W2084956669 @default.
- W1999278370 cites W2092907094 @default.
- W1999278370 doi "https://doi.org/10.1016/j.talanta.2009.01.058" @default.
- W1999278370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19362193" @default.
- W1999278370 hasPublicationYear "2009" @default.
- W1999278370 type Work @default.
- W1999278370 sameAs 1999278370 @default.
- W1999278370 citedByCount "25" @default.
- W1999278370 countsByYear W19992783702012 @default.
- W1999278370 countsByYear W19992783702013 @default.
- W1999278370 countsByYear W19992783702014 @default.
- W1999278370 countsByYear W19992783702015 @default.
- W1999278370 countsByYear W19992783702016 @default.
- W1999278370 countsByYear W19992783702017 @default.
- W1999278370 countsByYear W19992783702018 @default.
- W1999278370 countsByYear W19992783702021 @default.
- W1999278370 countsByYear W19992783702022 @default.
- W1999278370 crossrefType "journal-article" @default.
- W1999278370 hasAuthorship W1999278370A5003374144 @default.
- W1999278370 hasAuthorship W1999278370A5015679073 @default.
- W1999278370 hasAuthorship W1999278370A5035241559 @default.
- W1999278370 hasAuthorship W1999278370A5045777007 @default.
- W1999278370 hasAuthorship W1999278370A5062167921 @default.
- W1999278370 hasAuthorship W1999278370A5071782352 @default.
- W1999278370 hasAuthorship W1999278370A5081815617 @default.
- W1999278370 hasAuthorship W1999278370A5083786936 @default.
- W1999278370 hasConcept C112705442 @default.
- W1999278370 hasConcept C121608353 @default.
- W1999278370 hasConcept C126322002 @default.
- W1999278370 hasConcept C179998833 @default.
- W1999278370 hasConcept C181389837 @default.
- W1999278370 hasConcept C185592680 @default.
- W1999278370 hasConcept C22979827 @default.
- W1999278370 hasConcept C2777176818 @default.
- W1999278370 hasConcept C2778812593 @default.
- W1999278370 hasConcept C2780192828 @default.
- W1999278370 hasConcept C2780962315 @default.
- W1999278370 hasConcept C43617362 @default.
- W1999278370 hasConcept C530470458 @default.
- W1999278370 hasConcept C61367390 @default.
- W1999278370 hasConcept C71924100 @default.
- W1999278370 hasConcept C98274493 @default.
- W1999278370 hasConceptScore W1999278370C112705442 @default.
- W1999278370 hasConceptScore W1999278370C121608353 @default.
- W1999278370 hasConceptScore W1999278370C126322002 @default.
- W1999278370 hasConceptScore W1999278370C179998833 @default.
- W1999278370 hasConceptScore W1999278370C181389837 @default.
- W1999278370 hasConceptScore W1999278370C185592680 @default.
- W1999278370 hasConceptScore W1999278370C22979827 @default.
- W1999278370 hasConceptScore W1999278370C2777176818 @default.
- W1999278370 hasConceptScore W1999278370C2778812593 @default.
- W1999278370 hasConceptScore W1999278370C2780192828 @default.
- W1999278370 hasConceptScore W1999278370C2780962315 @default.
- W1999278370 hasConceptScore W1999278370C43617362 @default.
- W1999278370 hasConceptScore W1999278370C530470458 @default.
- W1999278370 hasConceptScore W1999278370C61367390 @default.
- W1999278370 hasConceptScore W1999278370C71924100 @default.
- W1999278370 hasConceptScore W1999278370C98274493 @default.
- W1999278370 hasIssue "4-5" @default.
- W1999278370 hasLocation W19992783701 @default.
- W1999278370 hasLocation W19992783702 @default.
- W1999278370 hasOpenAccess W1999278370 @default.
- W1999278370 hasPrimaryLocation W19992783701 @default.
- W1999278370 hasRelatedWork W1969574919 @default.
- W1999278370 hasRelatedWork W2030240071 @default.
- W1999278370 hasRelatedWork W2033151 @default.
- W1999278370 hasRelatedWork W2068318921 @default.
- W1999278370 hasRelatedWork W2080955156 @default.
- W1999278370 hasRelatedWork W2373237830 @default.
- W1999278370 hasRelatedWork W2375301095 @default.
- W1999278370 hasRelatedWork W2401080248 @default.
- W1999278370 hasRelatedWork W2587902810 @default.
- W1999278370 hasRelatedWork W2741671832 @default.
- W1999278370 hasVolume "78" @default.
- W1999278370 isParatext "false" @default.
- W1999278370 isRetracted "false" @default.
- W1999278370 magId "1999278370" @default.
- W1999278370 workType "article" @default.