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• W1999287766 startingPage "601" @default.
• W1999287766 abstract "Dendritic cells (DCs) are potent antigen presenting cells that exist in virtually every tissue, and from which they capture antigens and migrate to secondary lymphoid organs where they activate naïve T cells. Although DCs are normally present in extremely small numbers in the circulation, recent advances in DC biology have allowed the development of methods to generate large numbers of these cells in vitro. Because of their immunoregulatory capacity, vaccination with tumor antigen-presenting DCs has been proposed as a treatment modality for cancer. In animal models, vaccination with DCs pulsed with tumor peptides, lysates, or RNA or loaded with apoptotic/necrotic tumor cells could induce significant antitumor CTL responses and antitumor immunity. However, the results from early clinical trails pointed to a need for additional improvement of DC-based vaccines before they could be considered as practical alternatives to the existing cancer treatment strategies. In this regard, subsequent studies have shown that DCs that express transgenes encoding tumor antigens are more potent primers of antitumor immunity both in vitro and in vivo than DCs simply pulsed with tumor peptides. Furthermore, DCs that have been engineered to express certain cytokines or chemokines can display a substantially improved maturation status, capacity to migrate to secondary lymphoid organs in vivo, and abilities to stimulate tumor-specific T cell responses and induce tumor immunity in vivo. In this review we also discuss a number of factors that are important considerations in designing DC vaccine strategies, including (i) the type and concentrations of tumor peptides used for pulsing DCs; (ii) the timing and intervals for DC vaccination/boostable data on DC vaccination portends bright prospects for this approach to tumor immune therapy, either alone or in conjunction with other therapies." @default.
• W1999287766 created "2016-06-24" @default.
• W1999287766 creator A5059916214 @default.
• W1999287766 creator A5071965865 @default.
• W1999287766 creator A5079727555 @default.
• W1999287766 date "2002-12-01" @default.
• W1999287766 modified "2023-09-25" @default.
• W1999287766 title "Advances in Dendritic Cell-Based Vaccine of Cancer" @default.
• W1999287766 cites W1479742818 @default.
• W1999287766 cites W1482806584 @default.
• W1999287766 cites W148337095 @default.
• W1999287766 cites W1496239631 @default.
• W1999287766 cites W1540648309 @default.
• W1999287766 cites W1561591381 @default.
• W1999287766 cites W1570968423 @default.
• W1999287766 cites W1581304569 @default.
• W1999287766 cites W1584203472 @default.
• W1999287766 cites W1585007382 @default.
• W1999287766 cites W1592589742 @default.
• W1999287766 cites W1594179287 @default.
• W1999287766 cites W1607689059 @default.
• W1999287766 cites W1661544713 @default.
• W1999287766 cites W1678167583 @default.
• W1999287766 cites W1851889911 @default.
• W1999287766 cites W1858218633 @default.
• W1999287766 cites W1878925351 @default.
• W1999287766 cites W1934655176 @default.
• W1999287766 cites W1963440056 @default.
• W1999287766 cites W1966344496 @default.
• W1999287766 cites W1967863944 @default.
• W1999287766 cites W1971038274 @default.
• W1999287766 cites W1972758309 @default.
• W1999287766 cites W1976239556 @default.
• W1999287766 cites W1976802937 @default.
• W1999287766 cites W1977945339 @default.
• W1999287766 cites W1978207494 @default.
• W1999287766 cites W1983467202 @default.
• W1999287766 cites W1991253178 @default.
• W1999287766 cites W1992339457 @default.
• W1999287766 cites W1995951180 @default.
• W1999287766 cites W1999023229 @default.
• W1999287766 cites W1999125634 @default.
• W1999287766 cites W2002507218 @default.
• W1999287766 cites W2002997762 @default.
• W1999287766 cites W2004353679 @default.
• W1999287766 cites W2007427208 @default.
• W1999287766 cites W2008236686 @default.
• W1999287766 cites W2011877310 @default.
• W1999287766 cites W2012148175 @default.
• W1999287766 cites W2015419935 @default.
• W1999287766 cites W2018029562 @default.
• W1999287766 cites W2018885103 @default.
• W1999287766 cites W2024107347 @default.
• W1999287766 cites W2027944395 @default.
• W1999287766 cites W2030230012 @default.
• W1999287766 cites W2031078224 @default.
• W1999287766 cites W2032516346 @default.
• W1999287766 cites W2036291495 @default.
• W1999287766 cites W2044949794 @default.
• W1999287766 cites W2046718813 @default.
• W1999287766 cites W2047611754 @default.
• W1999287766 cites W2047903168 @default.
• W1999287766 cites W2048737697 @default.
• W1999287766 cites W2050653614 @default.
• W1999287766 cites W2052118083 @default.
• W1999287766 cites W2053760636 @default.
• W1999287766 cites W2054262963 @default.
• W1999287766 cites W2055674147 @default.
• W1999287766 cites W2057189505 @default.
• W1999287766 cites W2059398217 @default.
• W1999287766 cites W2062350041 @default.
• W1999287766 cites W2066298818 @default.
• W1999287766 cites W2066799804 @default.
• W1999287766 cites W2066964346 @default.
• W1999287766 cites W2067489645 @default.
• W1999287766 cites W2074566129 @default.
• W1999287766 cites W2076666674 @default.
• W1999287766 cites W2078176299 @default.
• W1999287766 cites W2081573122 @default.
• W1999287766 cites W2089723029 @default.
• W1999287766 cites W2092235636 @default.
• W1999287766 cites W2097808656 @default.
• W1999287766 cites W2100446366 @default.
• W1999287766 cites W2109044040 @default.
• W1999287766 cites W2115439647 @default.
• W1999287766 cites W2116286338 @default.
• W1999287766 cites W2116415376 @default.
• W1999287766 cites W2119817247 @default.
• W1999287766 cites W2121633252 @default.
• W1999287766 cites W2124376809 @default.
• W1999287766 cites W2128117338 @default.
• W1999287766 cites W2129980000 @default.
• W1999287766 cites W2131523916 @default.
• W1999287766 cites W2136355116 @default.
• W1999287766 cites W2136502025 @default.
• W1999287766 cites W2139620037 @default.
• W1999287766 cites W2140944306 @default.
• W1999287766 cites W2141346620 @default.

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