Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999291808> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1999291808 endingPage "173" @default.
- W1999291808 startingPage "167" @default.
- W1999291808 abstract "The reversal of insulin effects on sugar transport and phosphodiesterase in fat cells was studied after arresting further actions of insulin with KCN, NaN3, 2,4-dinitrophenol, or dicumarol. These agents rapidly lower the ATP concentration and concomitantly block the actions of insulin added later. Contrary to our expectation, the above inhibitors failed to initiate deactivation of the hormone-stimulated transport system. Instead, in the presence of the agents the transport system remained activated even after cells had been washed with an insulin-free buffer. This effect of the inhibitors was reversed when cells were washed with an inhibitor-free buffer containing glucose or pyruvate. The above inhibitors also blocked the deactivation of sugar transport stimulated by mechanical agitation. The effects of the inhibitors could not be explained by their possible effects on the basal transport activity, the intracellular urea space, or the cell count. The insulin-stimulated phosphodiesterase activity was rapidly lowered when cells were exposed to the above inhibitors. Apparently, these agents did not denature phosphodiesterase itself since the latter could be reactivated by insulin when inhibitor-treated cells were washed with a glucose-containing buffer. None of the above agents, except dicumarol, significantly inhibited phosphodiesterase activity in a cell-free system. It is suggested that the effects of insulin on sugar transport and phosphodiesterase are reversed by different mechanisms. ATP or metabolic energy may be involved in the deactivation of sugar transport, but not in that of phosphodiesterase." @default.
- W1999291808 created "2016-06-24" @default.
- W1999291808 creator A5032398504 @default.
- W1999291808 creator A5055286098 @default.
- W1999291808 creator A5068182385 @default.
- W1999291808 creator A5028729011 @default.
- W1999291808 date "1980-08-01" @default.
- W1999291808 modified "2023-10-09" @default.
- W1999291808 title "Reversal of insulin effects in fat cells may require energy for deactivation of glucose transport, but not for deactivation of phosphodiesterase" @default.
- W1999291808 cites W123467347 @default.
- W1999291808 cites W1480810179 @default.
- W1999291808 cites W153130060 @default.
- W1999291808 cites W1560440045 @default.
- W1999291808 cites W1579181700 @default.
- W1999291808 cites W1775749144 @default.
- W1999291808 cites W1864836751 @default.
- W1999291808 cites W2059906465 @default.
- W1999291808 cites W2073673616 @default.
- W1999291808 cites W2086623105 @default.
- W1999291808 cites W2086906852 @default.
- W1999291808 cites W2125032912 @default.
- W1999291808 cites W2143873575 @default.
- W1999291808 cites W4300044664 @default.
- W1999291808 cites W4323913119 @default.
- W1999291808 doi "https://doi.org/10.1016/0003-9861(80)90165-4" @default.
- W1999291808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6157364" @default.
- W1999291808 hasPublicationYear "1980" @default.
- W1999291808 type Work @default.
- W1999291808 sameAs 1999291808 @default.
- W1999291808 citedByCount "36" @default.
- W1999291808 crossrefType "journal-article" @default.
- W1999291808 hasAuthorship W1999291808A5028729011 @default.
- W1999291808 hasAuthorship W1999291808A5032398504 @default.
- W1999291808 hasAuthorship W1999291808A5055286098 @default.
- W1999291808 hasAuthorship W1999291808A5068182385 @default.
- W1999291808 hasConcept C126322002 @default.
- W1999291808 hasConcept C134018914 @default.
- W1999291808 hasConcept C161573976 @default.
- W1999291808 hasConcept C181199279 @default.
- W1999291808 hasConcept C185592680 @default.
- W1999291808 hasConcept C2776766087 @default.
- W1999291808 hasConcept C2777108408 @default.
- W1999291808 hasConcept C2777866211 @default.
- W1999291808 hasConcept C2778421351 @default.
- W1999291808 hasConcept C2779306644 @default.
- W1999291808 hasConcept C55493867 @default.
- W1999291808 hasConcept C62826618 @default.
- W1999291808 hasConcept C71924100 @default.
- W1999291808 hasConcept C79879829 @default.
- W1999291808 hasConcept C86803240 @default.
- W1999291808 hasConceptScore W1999291808C126322002 @default.
- W1999291808 hasConceptScore W1999291808C134018914 @default.
- W1999291808 hasConceptScore W1999291808C161573976 @default.
- W1999291808 hasConceptScore W1999291808C181199279 @default.
- W1999291808 hasConceptScore W1999291808C185592680 @default.
- W1999291808 hasConceptScore W1999291808C2776766087 @default.
- W1999291808 hasConceptScore W1999291808C2777108408 @default.
- W1999291808 hasConceptScore W1999291808C2777866211 @default.
- W1999291808 hasConceptScore W1999291808C2778421351 @default.
- W1999291808 hasConceptScore W1999291808C2779306644 @default.
- W1999291808 hasConceptScore W1999291808C55493867 @default.
- W1999291808 hasConceptScore W1999291808C62826618 @default.
- W1999291808 hasConceptScore W1999291808C71924100 @default.
- W1999291808 hasConceptScore W1999291808C79879829 @default.
- W1999291808 hasConceptScore W1999291808C86803240 @default.
- W1999291808 hasIssue "1" @default.
- W1999291808 hasLocation W19992918081 @default.
- W1999291808 hasLocation W19992918082 @default.
- W1999291808 hasOpenAccess W1999291808 @default.
- W1999291808 hasPrimaryLocation W19992918081 @default.
- W1999291808 hasRelatedWork W1971859682 @default.
- W1999291808 hasRelatedWork W1994965139 @default.
- W1999291808 hasRelatedWork W2107510101 @default.
- W1999291808 hasRelatedWork W2414633774 @default.
- W1999291808 hasRelatedWork W2547069902 @default.
- W1999291808 hasRelatedWork W2726421366 @default.
- W1999291808 hasRelatedWork W2745827302 @default.
- W1999291808 hasRelatedWork W4211103015 @default.
- W1999291808 hasRelatedWork W4285741418 @default.
- W1999291808 hasRelatedWork W4309722971 @default.
- W1999291808 hasVolume "203" @default.
- W1999291808 isParatext "false" @default.
- W1999291808 isRetracted "false" @default.
- W1999291808 magId "1999291808" @default.
- W1999291808 workType "article" @default.