FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999308081> ?p ?o ?g. }

• W1999308081 endingPage "e218" @default.
• W1999308081 startingPage "e212" @default.
• W1999308081 abstract "This open-label, single-arm, phase I/II, dose-escalation study was designed to determine the recommended phase II dose (RP2D), pharmacokinetics, tolerability, and efficacy of bendamustine in pediatric patients (age ranging from 1 to 20 y) with histologically proven relapsed/refractory acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML). Patients (27 with ALL, 16 with AML) received intravenous bendamustine on days 1 and 2 of each treatment cycle. Phase I involved planned dose escalation of bendamustine to establish the RP2D for phase II. Objectives included overall response rate, duration of response, and tolerability. Eleven patients were treated in phase I, and the RP2D was 120 mg/m2. In phase II, 32 patients received bendamustine 120 mg/m2. Two patients with ALL (bendamustine 90 mg/m2) experienced complete response (CR). Among patients who received bendamustine 120 mg/m2, 2 experienced partial response (PR); 7 had stable disease. The overall response rate (CR+CR without platelet recovery [CRp]) was 4.7% and biological activity rate (CR+CRp+PR) was 9.3%. No AML patients responded. The most common adverse events were anemia, neutropenia, thrombocytopenia, pyrexia, nausea, vomiting, and diarrhea. Bendamustine monotherapy has acceptable tolerability in heavily pretreated children with relapsed/refractory ALL or AML and appears to have some activity in ALL, warranting further studies in combination trials." @default.
• W1999308081 created "2016-06-24" @default.
• W1999308081 creator A5000976107 @default.
• W1999308081 creator A5007182073 @default.
• W1999308081 creator A5014044521 @default.
• W1999308081 creator A5037359116 @default.
• W1999308081 creator A5045769455 @default.
• W1999308081 creator A5047568799 @default.
• W1999308081 creator A5065627642 @default.
• W1999308081 creator A5073690360 @default.
• W1999308081 creator A5076062165 @default.
• W1999308081 creator A5081397248 @default.
• W1999308081 creator A5083442088 @default.
• W1999308081 creator A5086323558 @default.
• W1999308081 date "2014-05-01" @default.
• W1999308081 modified "2023-09-27" @default.
• W1999308081 title "Open-label Bendamustine Monotherapy for Pediatric Patients With Relapsed or Refractory Acute Leukemia" @default.
• W1999308081 cites W1522465334 @default.
• W1999308081 cites W2002027837 @default.
• W1999308081 cites W2054811026 @default.
• W1999308081 cites W2128936398 @default.
• W1999308081 cites W2142019712 @default.
• W1999308081 cites W2150280279 @default.
• W1999308081 cites W2163348695 @default.
• W1999308081 cites W2168399216 @default.
• W1999308081 cites W2147083172 @default.
• W1999308081 doi "https://doi.org/10.1097/mph.0000000000000021" @default.
• W1999308081 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4020582" @default.
• W1999308081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24072240" @default.
• W1999308081 hasPublicationYear "2014" @default.
• W1999308081 type Work @default.
• W1999308081 sameAs 1999308081 @default.
• W1999308081 citedByCount "11" @default.
• W1999308081 countsByYear W19993080812014 @default.
• W1999308081 countsByYear W19993080812015 @default.
• W1999308081 countsByYear W19993080812016 @default.
• W1999308081 countsByYear W19993080812019 @default.
• W1999308081 countsByYear W19993080812020 @default.
• W1999308081 countsByYear W19993080812021 @default.
• W1999308081 countsByYear W19993080812022 @default.
• W1999308081 crossrefType "journal-article" @default.
• W1999308081 hasAuthorship W1999308081A5000976107 @default.
• W1999308081 hasAuthorship W1999308081A5007182073 @default.
• W1999308081 hasAuthorship W1999308081A5014044521 @default.
• W1999308081 hasAuthorship W1999308081A5037359116 @default.
• W1999308081 hasAuthorship W1999308081A5045769455 @default.
• W1999308081 hasAuthorship W1999308081A5047568799 @default.
• W1999308081 hasAuthorship W1999308081A5065627642 @default.
• W1999308081 hasAuthorship W1999308081A5073690360 @default.
• W1999308081 hasAuthorship W1999308081A5076062165 @default.
• W1999308081 hasAuthorship W1999308081A5081397248 @default.
• W1999308081 hasAuthorship W1999308081A5083442088 @default.
• W1999308081 hasAuthorship W1999308081A5086323558 @default.
• W1999308081 hasBestOaLocation W19993080811 @default.
• W1999308081 hasConcept C126322002 @default.
• W1999308081 hasConcept C197934379 @default.
• W1999308081 hasConcept C2776694085 @default.
• W1999308081 hasConcept C2776863199 @default.
• W1999308081 hasConcept C2777063308 @default.
• W1999308081 hasConcept C2777938653 @default.
• W1999308081 hasConcept C2778375690 @default.
• W1999308081 hasConcept C2778461978 @default.
• W1999308081 hasConcept C2778850193 @default.
• W1999308081 hasConcept C2780580376 @default.
• W1999308081 hasConcept C2781442060 @default.
• W1999308081 hasConcept C31760486 @default.
• W1999308081 hasConcept C535046627 @default.
• W1999308081 hasConcept C71924100 @default.
• W1999308081 hasConcept C90924648 @default.
• W1999308081 hasConceptScore W1999308081C126322002 @default.
• W1999308081 hasConceptScore W1999308081C197934379 @default.
• W1999308081 hasConceptScore W1999308081C2776694085 @default.
• W1999308081 hasConceptScore W1999308081C2776863199 @default.
• W1999308081 hasConceptScore W1999308081C2777063308 @default.
• W1999308081 hasConceptScore W1999308081C2777938653 @default.
• W1999308081 hasConceptScore W1999308081C2778375690 @default.
• W1999308081 hasConceptScore W1999308081C2778461978 @default.
• W1999308081 hasConceptScore W1999308081C2778850193 @default.
• W1999308081 hasConceptScore W1999308081C2780580376 @default.
• W1999308081 hasConceptScore W1999308081C2781442060 @default.
• W1999308081 hasConceptScore W1999308081C31760486 @default.
• W1999308081 hasConceptScore W1999308081C535046627 @default.
• W1999308081 hasConceptScore W1999308081C71924100 @default.
• W1999308081 hasConceptScore W1999308081C90924648 @default.
• W1999308081 hasIssue "4" @default.
• W1999308081 hasLocation W19993080811 @default.
• W1999308081 hasLocation W19993080812 @default.
• W1999308081 hasLocation W19993080813 @default.
• W1999308081 hasLocation W19993080814 @default.
• W1999308081 hasLocation W19993080815 @default.
• W1999308081 hasOpenAccess W1999308081 @default.
• W1999308081 hasPrimaryLocation W19993080811 @default.
• W1999308081 hasRelatedWork W2014862321 @default.
• W1999308081 hasRelatedWork W2022556905 @default.
• W1999308081 hasRelatedWork W2028444391 @default.
• W1999308081 hasRelatedWork W2066251854 @default.
• W1999308081 hasRelatedWork W2083329993 @default.
• W1999308081 hasRelatedWork W2150129319 @default.

• next