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- W1999314991 abstract "ABSTRACT Francisella tularensis , a gram-negative bacterium, is the etiologic agent of tularemia and has recently been classified as a category A bioterrorism agent. Infections with F. tularensis result in an inflammatory response that plays an important role in the pathogenesis of the disease; however, the cellular mechanisms mediating this response have not been completely elucidated. In the present study, we determined the role of Toll-like receptors (TLRs) in mediating inflammatory responses to F. tularensis LVS, and the role of NF-κB in regulating these responses. Stimulation of bone marrow-derived dendritic cells from C57BL/6 wild-type (wt) and TLR4 −/− but not TLR2 −/− mice, with live F. tularensis LVS elicited a dose-dependent increase in the production of tumor necrosis factor alpha. F. tularensis LVS also induced in a dose-dependent manner an up-regulation in the expression of the costimulatory molecules CD80 and CD86 and of CD40 and the major histocompatibility complex class II molecules on dendritic cells from wt and TLR4 −/− but not TLR2 −/− mice. TLR6, not TLR1, was shown to be involved in mediating the inflammatory response to F. tularensis LVS, indicating that the functional heterodimer is TLR2/TLR6. Stimulation of dendritic cells with F. tularensis resulted in the activation of NF-κB, which resulted in a differential effect on the production of pro- and anti-inflammatory cytokines. Taken together, our results demonstrate the role of TLR2/TLR6 in the host's inflammatory response to F. tularensis LVS in vitro and the regulatory function of NF-κB in modulating the inflammatory response." @default.
- W1999314991 created "2016-06-24" @default.
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- W1999314991 date "2006-05-01" @default.
- W1999314991 modified "2023-10-02" @default.
- W1999314991 title "Toll-Like Receptor 2 Is Required for Inflammatory Responses to<i>Francisella tularensis</i>LVS" @default.
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- W1999314991 doi "https://doi.org/10.1128/iai.74.5.2809-2816.2006" @default.
- W1999314991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1459727" @default.
- W1999314991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16622218" @default.
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