FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999316208> ?p ?o ?g. }

• W1999316208 endingPage "785" @default.
• W1999316208 startingPage "780" @default.
• W1999316208 abstract "parkin loss associated early-onset of Parkinson's disease, involves mitochondrial dysfunction and oxidative stress as the plausible decisive molecular mechanisms in disease pathogenesis. Mitochondrial dysfunction involves several up/down regulation of gene products, one of which being p53 is found to be elevated. Elevated p53 is involved in mitochondrial mediated apoptosis of neuronal cells in Parkinson's patients who are folate deficient as well. The present study therefore attempts to examine the effect of Folic acid (FA) supplementation in alleviation of anomalies associated with parkin knockdown using RNAi approach, specific to Dopaminergic (DA) neurons in Drosophila model system. Here we show that FA supplementation provide protection against parkin RNAi associated discrepancies, thereby improves locomotor ability, reduces mortality and oxidative stress, and partially improves Zn levels. Further, metabolic active cell status and ATP levels were also found to be improved thereby indicating improved mitochondrial function. To corroborate FA supplementation in mitochondrial functioning further, status of p53 and spargel was checked by qRT-PCR. Here we show that folic acid supplementation enrich mitochondrial functioning as depicted from improved spargel level and lowered p53 level, which was originally vice versa in parkin knockdown flies cultured in standard media. Our data thus support the potential of folic acid in alleviating the behavioural defects, oxidative stress, augmentation of zinc and ATP levels in parkin knock down flies. Further, folic acid role in repressing mitochondrial dysfunction is encouraging to further explore its possible mechanistic role to be utilized as potential therapeutics for Parkinson's disease." @default.
• W1999316208 created "2016-06-24" @default.
• W1999316208 creator A5005765365 @default.
• W1999316208 creator A5011486337 @default.
• W1999316208 creator A5029990030 @default.
• W1999316208 creator A5084798963 @default.
• W1999316208 date "2015-05-01" @default.
• W1999316208 modified "2023-09-26" @default.
• W1999316208 title "Folic acid supplementation rescues anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinson's disease" @default.
• W1999316208 cites W1877873625 @default.
• W1999316208 cites W1963494046 @default.
• W1999316208 cites W1978680540 @default.
• W1999316208 cites W1983310681 @default.
• W1999316208 cites W1990527253 @default.
• W1999316208 cites W1992852556 @default.
• W1999316208 cites W1997144351 @default.
• W1999316208 cites W2011603170 @default.
• W1999316208 cites W2024610036 @default.
• W1999316208 cites W2025444083 @default.
• W1999316208 cites W2032730372 @default.
• W1999316208 cites W2033952333 @default.
• W1999316208 cites W2039824115 @default.
• W1999316208 cites W2052211882 @default.
• W1999316208 cites W2055124287 @default.
• W1999316208 cites W2069448970 @default.
• W1999316208 cites W2080773722 @default.
• W1999316208 cites W2091930637 @default.
• W1999316208 cites W2092914873 @default.
• W1999316208 cites W2101672833 @default.
• W1999316208 cites W2101678659 @default.
• W1999316208 cites W2146373470 @default.
• W1999316208 cites W2148113868 @default.
• W1999316208 cites W2155015733 @default.
• W1999316208 cites W2161688851 @default.
• W1999316208 doi "https://doi.org/10.1016/j.bbrc.2015.03.106" @default.
• W1999316208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25824034" @default.
• W1999316208 hasPublicationYear "2015" @default.
• W1999316208 type Work @default.
• W1999316208 sameAs 1999316208 @default.
• W1999316208 citedByCount "16" @default.
• W1999316208 countsByYear W19993162082016 @default.
• W1999316208 countsByYear W19993162082017 @default.
• W1999316208 countsByYear W19993162082019 @default.
• W1999316208 countsByYear W19993162082020 @default.
• W1999316208 countsByYear W19993162082021 @default.
• W1999316208 countsByYear W19993162082022 @default.
• W1999316208 crossrefType "journal-article" @default.
• W1999316208 hasAuthorship W1999316208A5005765365 @default.
• W1999316208 hasAuthorship W1999316208A5011486337 @default.
• W1999316208 hasAuthorship W1999316208A5029990030 @default.
• W1999316208 hasAuthorship W1999316208A5084798963 @default.
• W1999316208 hasConcept C104317684 @default.
• W1999316208 hasConcept C126322002 @default.
• W1999316208 hasConcept C134018914 @default.
• W1999316208 hasConcept C137183658 @default.
• W1999316208 hasConcept C166703698 @default.
• W1999316208 hasConcept C170493617 @default.
• W1999316208 hasConcept C173396325 @default.
• W1999316208 hasConcept C190283241 @default.
• W1999316208 hasConcept C203522944 @default.
• W1999316208 hasConcept C2775864247 @default.
• W1999316208 hasConcept C2776151105 @default.
• W1999316208 hasConcept C2776804853 @default.
• W1999316208 hasConcept C2777668072 @default.
• W1999316208 hasConcept C2779134260 @default.
• W1999316208 hasConcept C2779324830 @default.
• W1999316208 hasConcept C2779734285 @default.
• W1999316208 hasConcept C28859421 @default.
• W1999316208 hasConcept C37000724 @default.
• W1999316208 hasConcept C513476851 @default.
• W1999316208 hasConcept C55493867 @default.
• W1999316208 hasConcept C67705224 @default.
• W1999316208 hasConcept C71924100 @default.
• W1999316208 hasConcept C86803240 @default.
• W1999316208 hasConcept C95444343 @default.
• W1999316208 hasConcept C98274493 @default.
• W1999316208 hasConceptScore W1999316208C104317684 @default.
• W1999316208 hasConceptScore W1999316208C126322002 @default.
• W1999316208 hasConceptScore W1999316208C134018914 @default.
• W1999316208 hasConceptScore W1999316208C137183658 @default.
• W1999316208 hasConceptScore W1999316208C166703698 @default.
• W1999316208 hasConceptScore W1999316208C170493617 @default.
• W1999316208 hasConceptScore W1999316208C173396325 @default.
• W1999316208 hasConceptScore W1999316208C190283241 @default.
• W1999316208 hasConceptScore W1999316208C203522944 @default.
• W1999316208 hasConceptScore W1999316208C2775864247 @default.
• W1999316208 hasConceptScore W1999316208C2776151105 @default.
• W1999316208 hasConceptScore W1999316208C2776804853 @default.
• W1999316208 hasConceptScore W1999316208C2777668072 @default.
• W1999316208 hasConceptScore W1999316208C2779134260 @default.
• W1999316208 hasConceptScore W1999316208C2779324830 @default.
• W1999316208 hasConceptScore W1999316208C2779734285 @default.
• W1999316208 hasConceptScore W1999316208C28859421 @default.
• W1999316208 hasConceptScore W1999316208C37000724 @default.
• W1999316208 hasConceptScore W1999316208C513476851 @default.
• W1999316208 hasConceptScore W1999316208C55493867 @default.
• W1999316208 hasConceptScore W1999316208C67705224 @default.
• W1999316208 hasConceptScore W1999316208C71924100 @default.

• next