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- W1999318388 abstract "To identify molecules that might serve as biomarkers or targets for the development of novel molecular therapies, we have been screening genes encoding transmembrane/secretory proteins that are up-regulated in lung cancers, using cDNA microarrays. During this process, we identified a secreted protein, LASEP1 (lung cancer-associated serum protein 1) as a candidate. Immunohistochemical staining using tumor tissue microarrays consisting of 374 non-small cell lung cancers (NSCLC) revealed that LASEP1 protein was frequently over-expressed in lung cancers; positive staining of LASEP1 was observed in 210 (56.1%) of 374 NSCLC, while that was observed in 9 (69.2%) of 13 small cell lung cancers (SCLC). In addition, a strong LASEP1 positivity was associated with poor prognosis for patients with NSCLC (P Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3005. doi:1538-7445.AM2012-3005" @default.
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- W1999318388 date "2012-04-15" @default.
- W1999318388 modified "2023-09-30" @default.
- W1999318388 title "Abstract 3005: Characterization of a lung cancer growth factor, LASEP1 as a serological and prognostic biomarker and a therapeutic target" @default.
- W1999318388 doi "https://doi.org/10.1158/1538-7445.am2012-3005" @default.
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