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• W1999320461 abstract "The iron-binding proteins, transferrin and ferritin, are involved in the processes of transport and storage in iron metabolism. Their expression is induced in response to iron overload. Here, we show the expression profile of transferrin (Bi-Tf) and the ferritin heavy chain subunit (Bi-FerHCH) of the bumblebee Bombus ignitus in response to iron overload. Bi-Tf exhibits fat body-specific expression, whereas Bi-FerHCH is ubiquitously expressed and upregulated in various tissues, though in a similar manner, by iron overload. We also demonstrate their expression regulation via reduction of Bi-Tf or Bi-FerHCH levels in the fat body via RNA interference (RNAi). Under uniform conditions in which FeCl(3) was overloaded, the RNAi-induced Bi-Tf knock-down B. ignitus worker bees showed upregulated expression of Bi-FerHCH, and reciprocally, Bi-FerHCH RNAi knockdowns showed upregulated Bi-Tf expression in the fat body. This result indicates that, in case of the loss of Bi-Tf or Bi-FerHCH, the expression of Bi-FerHCH or Bi-Tf, respectively, is upregulated in response to iron overload." @default.
• W1999320461 created "2016-06-24" @default.
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• W1999320461 date "2009-06-01" @default.
• W1999320461 modified "2023-10-18" @default.
• W1999320461 title "Expression profile of the iron-binding proteins transferrin and ferritin heavy chain subunit in the bumblebee Bombus ignitus" @default.
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• W1999320461 doi "https://doi.org/10.1016/j.cbpb.2009.02.014" @default.
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