Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999331452> ?p ?o ?g. }
- W1999331452 endingPage "6425" @default.
- W1999331452 startingPage "6420" @default.
- W1999331452 abstract "Based on the observed biological activities of coumarins and resveratrol, we synthesized fourteen hydroxylated 3-phenylcoumarins (stilbene-coumarin hybrids) including six novel ortho-hydroxy-methoxy substituted derivatives, 1-14, by Perkin reaction. We characterized these compounds concerning their antioxidant activity against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH)-induced pBR322 DNA strand breakage, and their antiproliferative effects on human promyelocytic leukemia HL-60 and human lung adenocarcinoma epithelial A549 cells. Structure-activity relationship information suggests that the introduction of ortho-hydroxy-methoxy groups and ortho-dihydroxy groups on the aromatic A ring could efficiently improve antiproliferative activity. Interestingly, a new derivative, 6-methoxy-7-hydroxy-3-(4'-hydroxyphenyl)coumarin, 9, behaved as a poor antioxidant but appeared to be the most potent antiproliferative agent among the compounds examined, and this activity was mediated by deregulation in cell cycle and induction of apoptosis." @default.
- W1999331452 created "2016-06-24" @default.
- W1999331452 creator A5000289221 @default.
- W1999331452 creator A5004829942 @default.
- W1999331452 creator A5013786490 @default.
- W1999331452 creator A5034443119 @default.
- W1999331452 creator A5038497048 @default.
- W1999331452 creator A5042310059 @default.
- W1999331452 creator A5063818470 @default.
- W1999331452 creator A5078332800 @default.
- W1999331452 creator A5082584032 @default.
- W1999331452 creator A5089855815 @default.
- W1999331452 creator A5091390223 @default.
- W1999331452 date "2011-11-01" @default.
- W1999331452 modified "2023-09-24" @default.
- W1999331452 title "Synthesis and biological evaluation of hydroxylated 3-phenylcoumarins as antioxidants and antiproliferative agents" @default.
- W1999331452 cites W1963978740 @default.
- W1999331452 cites W1966056100 @default.
- W1999331452 cites W1967269478 @default.
- W1999331452 cites W1977345060 @default.
- W1999331452 cites W1986303437 @default.
- W1999331452 cites W1989131731 @default.
- W1999331452 cites W1994998060 @default.
- W1999331452 cites W2000061453 @default.
- W1999331452 cites W2006609360 @default.
- W1999331452 cites W2010821874 @default.
- W1999331452 cites W2011044704 @default.
- W1999331452 cites W2017618924 @default.
- W1999331452 cites W2017675726 @default.
- W1999331452 cites W2018009940 @default.
- W1999331452 cites W2019957422 @default.
- W1999331452 cites W2041951165 @default.
- W1999331452 cites W2053995027 @default.
- W1999331452 cites W2060924028 @default.
- W1999331452 cites W2061776537 @default.
- W1999331452 cites W2083698469 @default.
- W1999331452 cites W2088725320 @default.
- W1999331452 cites W2093574265 @default.
- W1999331452 cites W2110890911 @default.
- W1999331452 cites W2119974603 @default.
- W1999331452 cites W2142732971 @default.
- W1999331452 cites W2150002690 @default.
- W1999331452 cites W2154587590 @default.
- W1999331452 cites W2169653856 @default.
- W1999331452 cites W2177886018 @default.
- W1999331452 cites W2231831983 @default.
- W1999331452 doi "https://doi.org/10.1016/j.bmcl.2011.08.090" @default.
- W1999331452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21920747" @default.
- W1999331452 hasPublicationYear "2011" @default.
- W1999331452 type Work @default.
- W1999331452 sameAs 1999331452 @default.
- W1999331452 citedByCount "62" @default.
- W1999331452 countsByYear W19993314522012 @default.
- W1999331452 countsByYear W19993314522013 @default.
- W1999331452 countsByYear W19993314522014 @default.
- W1999331452 countsByYear W19993314522015 @default.
- W1999331452 countsByYear W19993314522016 @default.
- W1999331452 countsByYear W19993314522017 @default.
- W1999331452 countsByYear W19993314522018 @default.
- W1999331452 countsByYear W19993314522019 @default.
- W1999331452 countsByYear W19993314522020 @default.
- W1999331452 countsByYear W19993314522021 @default.
- W1999331452 countsByYear W19993314522022 @default.
- W1999331452 crossrefType "journal-article" @default.
- W1999331452 hasAuthorship W1999331452A5000289221 @default.
- W1999331452 hasAuthorship W1999331452A5004829942 @default.
- W1999331452 hasAuthorship W1999331452A5013786490 @default.
- W1999331452 hasAuthorship W1999331452A5034443119 @default.
- W1999331452 hasAuthorship W1999331452A5038497048 @default.
- W1999331452 hasAuthorship W1999331452A5042310059 @default.
- W1999331452 hasAuthorship W1999331452A5063818470 @default.
- W1999331452 hasAuthorship W1999331452A5078332800 @default.
- W1999331452 hasAuthorship W1999331452A5082584032 @default.
- W1999331452 hasAuthorship W1999331452A5089855815 @default.
- W1999331452 hasAuthorship W1999331452A5091390223 @default.
- W1999331452 hasConcept C109316439 @default.
- W1999331452 hasConcept C116073593 @default.
- W1999331452 hasConcept C178790620 @default.
- W1999331452 hasConcept C185592680 @default.
- W1999331452 hasConcept C190283241 @default.
- W1999331452 hasConcept C202751555 @default.
- W1999331452 hasConcept C2776460385 @default.
- W1999331452 hasConcept C2776816829 @default.
- W1999331452 hasConcept C2778004101 @default.
- W1999331452 hasConcept C2781338262 @default.
- W1999331452 hasConcept C55493867 @default.
- W1999331452 hasConcept C71240020 @default.
- W1999331452 hasConcept C81729549 @default.
- W1999331452 hasConceptScore W1999331452C109316439 @default.
- W1999331452 hasConceptScore W1999331452C116073593 @default.
- W1999331452 hasConceptScore W1999331452C178790620 @default.
- W1999331452 hasConceptScore W1999331452C185592680 @default.
- W1999331452 hasConceptScore W1999331452C190283241 @default.
- W1999331452 hasConceptScore W1999331452C202751555 @default.
- W1999331452 hasConceptScore W1999331452C2776460385 @default.
- W1999331452 hasConceptScore W1999331452C2776816829 @default.
- W1999331452 hasConceptScore W1999331452C2778004101 @default.
- W1999331452 hasConceptScore W1999331452C2781338262 @default.