Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999331681> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1999331681 endingPage "226" @default.
- W1999331681 startingPage "219" @default.
- W1999331681 abstract "Objective: To further elucidate the mechanism by which cytomegalovirus (CMV) may promote atherosclerosis, we studied the expression pattern of cellular inflammatory and proliferative signals in the aortic wall of CMV(+) and CMV(-) patients undergoing coronary artery bypass grafting (CABG). Methods: Aortic biopsies and blood samples of 68 CABG patients were investigated for CMV‐DNA by PCR and in situ hybridisation. Expression of pp65 antigen, adhesion molecules (ICAM-1, VCAM-1, E-selectin), growth factors (PDGF‐AA, TGF-β), and the cellular proliferation factor Ki-67 was studied by immunohistochemistry. Logistic regression was used to test the correlation between the presence of CMV, vascular inflammation, and traditional noninflammatory risk factors for atherosclerosis. Results: CMV‐DNA was detected in the aortic tissue of 52 (76 %) patients, and was localised predominantly in vascular smooth muscle cells. In CMV(+) patients, the expression of adhesion molecules and growth factors in the aortic endothelium was increased compared with CMV(-) patients. A positive correlation of elevated CRP, the induction of adhesion molecules and growth factors and CMV(+) was found. Female gender, smoking, and hyperlipidaemia were identified as risk factors for CMV(+). Conclusions: CMV‐DNA in smooth muscle cells induces local growth factor expression as well as endothelial activation, both of which can promote the progression of atherosclerosis. Since traditional atherogenic risk factors increase the likelihood of aortic CMV manifestation, we suggest that CMV plays a crucial role in mediating the progression of atherosclerosis." @default.
- W1999331681 created "2016-06-24" @default.
- W1999331681 creator A5032685005 @default.
- W1999331681 creator A5037285192 @default.
- W1999331681 creator A5053395803 @default.
- W1999331681 creator A5055249856 @default.
- W1999331681 creator A5064367620 @default.
- W1999331681 creator A5075357366 @default.
- W1999331681 creator A5083575661 @default.
- W1999331681 creator A5088101682 @default.
- W1999331681 date "2006-06-01" @default.
- W1999331681 modified "2023-10-18" @default.
- W1999331681 title "Cytomegalovirus and Proliferative Signals in the Vascular Wall of CABG Patients" @default.
- W1999331681 doi "https://doi.org/10.1055/s-2006-923891" @default.
- W1999331681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16755441" @default.
- W1999331681 hasPublicationYear "2006" @default.
- W1999331681 type Work @default.
- W1999331681 sameAs 1999331681 @default.
- W1999331681 citedByCount "16" @default.
- W1999331681 countsByYear W19993316812012 @default.
- W1999331681 countsByYear W19993316812013 @default.
- W1999331681 countsByYear W19993316812015 @default.
- W1999331681 countsByYear W19993316812018 @default.
- W1999331681 countsByYear W19993316812020 @default.
- W1999331681 countsByYear W19993316812022 @default.
- W1999331681 countsByYear W19993316812023 @default.
- W1999331681 crossrefType "journal-article" @default.
- W1999331681 hasAuthorship W1999331681A5032685005 @default.
- W1999331681 hasAuthorship W1999331681A5037285192 @default.
- W1999331681 hasAuthorship W1999331681A5053395803 @default.
- W1999331681 hasAuthorship W1999331681A5055249856 @default.
- W1999331681 hasAuthorship W1999331681A5064367620 @default.
- W1999331681 hasAuthorship W1999331681A5075357366 @default.
- W1999331681 hasAuthorship W1999331681A5083575661 @default.
- W1999331681 hasAuthorship W1999331681A5088101682 @default.
- W1999331681 hasConcept C126322002 @default.
- W1999331681 hasConcept C16224149 @default.
- W1999331681 hasConcept C170493617 @default.
- W1999331681 hasConcept C185946421 @default.
- W1999331681 hasConcept C203014093 @default.
- W1999331681 hasConcept C204232928 @default.
- W1999331681 hasConcept C2522874641 @default.
- W1999331681 hasConcept C2775960820 @default.
- W1999331681 hasConcept C2776246508 @default.
- W1999331681 hasConcept C2776409557 @default.
- W1999331681 hasConcept C2776820930 @default.
- W1999331681 hasConcept C2776914184 @default.
- W1999331681 hasConcept C2776985958 @default.
- W1999331681 hasConcept C2776992346 @default.
- W1999331681 hasConcept C2777732132 @default.
- W1999331681 hasConcept C2779395532 @default.
- W1999331681 hasConcept C2780727368 @default.
- W1999331681 hasConcept C2992686903 @default.
- W1999331681 hasConcept C71924100 @default.
- W1999331681 hasConceptScore W1999331681C126322002 @default.
- W1999331681 hasConceptScore W1999331681C16224149 @default.
- W1999331681 hasConceptScore W1999331681C170493617 @default.
- W1999331681 hasConceptScore W1999331681C185946421 @default.
- W1999331681 hasConceptScore W1999331681C203014093 @default.
- W1999331681 hasConceptScore W1999331681C204232928 @default.
- W1999331681 hasConceptScore W1999331681C2522874641 @default.
- W1999331681 hasConceptScore W1999331681C2775960820 @default.
- W1999331681 hasConceptScore W1999331681C2776246508 @default.
- W1999331681 hasConceptScore W1999331681C2776409557 @default.
- W1999331681 hasConceptScore W1999331681C2776820930 @default.
- W1999331681 hasConceptScore W1999331681C2776914184 @default.
- W1999331681 hasConceptScore W1999331681C2776985958 @default.
- W1999331681 hasConceptScore W1999331681C2776992346 @default.
- W1999331681 hasConceptScore W1999331681C2777732132 @default.
- W1999331681 hasConceptScore W1999331681C2779395532 @default.
- W1999331681 hasConceptScore W1999331681C2780727368 @default.
- W1999331681 hasConceptScore W1999331681C2992686903 @default.
- W1999331681 hasConceptScore W1999331681C71924100 @default.
- W1999331681 hasIssue "4" @default.
- W1999331681 hasLocation W19993316811 @default.
- W1999331681 hasLocation W19993316812 @default.
- W1999331681 hasOpenAccess W1999331681 @default.
- W1999331681 hasPrimaryLocation W19993316811 @default.
- W1999331681 hasRelatedWork W169646064 @default.
- W1999331681 hasRelatedWork W1977793874 @default.
- W1999331681 hasRelatedWork W1986881834 @default.
- W1999331681 hasRelatedWork W1992082902 @default.
- W1999331681 hasRelatedWork W2010786744 @default.
- W1999331681 hasRelatedWork W2034269870 @default.
- W1999331681 hasRelatedWork W2072139527 @default.
- W1999331681 hasRelatedWork W3093812827 @default.
- W1999331681 hasRelatedWork W3139691921 @default.
- W1999331681 hasRelatedWork W4295835870 @default.
- W1999331681 hasVolume "54" @default.
- W1999331681 isParatext "false" @default.
- W1999331681 isRetracted "false" @default.
- W1999331681 magId "1999331681" @default.
- W1999331681 workType "article" @default.