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- W1999347750 abstract "Purpose: To study the efficacy of topical administration of gatifloxacin (0.3%), moxifloxacin (0.5%) ophthalmic solutions, and besifloxacin (0.6%) ophthalmic suspension as prophylaxis and treatment of pneumococcal endophthalmitis. Methods: Four groups of New Zealand white rabbits were topically treated with gatifloxacin, moxifloxacin, besifloxacin, and phosphate-buffered saline (PBS) at the following time points: 60, 45, 30, and 15 min before infection, immediately after infection, and then 6, 12, 18, and 24 h postinfection. Penicillin-resistant Streptococcus pneumoniae (PRSP; 106 colony-forming unit [CFU] in 50 μL) was injected into the aqueous humor of each eye. The clinical severity of the eyes was assessed by 2 masked observers 24 h postinfection. Aqueous and vitreous samples were collected, diluted, and plated to determine recovered CFU. Results: Fluoroquinolone-treated eyes had significantly lower clinical scores and bacteria recovered from the aqueous humor than the PBS-treated eyes. There was no difference, however, among the fluoroquinolone-treated groups. In contrast, none of the fluoroquinolones reduced the number of bacteria recovered (CFU) from the vitreous humor. Conclusions: Besifloxacin is as effective as moxifloxacin and gatifloxacin in a rabbit model for topical prophylaxis and treatment of PRSP-induced endophthalmitis." @default.
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- W1999347750 date "2010-06-01" @default.
- W1999347750 modified "2023-09-27" @default.
- W1999347750 title "Comparative Efficacy of Besifloxacin and Other Fluoroquinolones in a Prophylaxis Model of Penicillin-Resistant<i>Streptococcus pneumoniae</i>Rabbit Endophthalmitis" @default.
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- W1999347750 doi "https://doi.org/10.1089/jop.2009.0154" @default.
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