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- W1999353649 abstract "The sensation of taste is mediated by electrical events in taste bud cells, which are embedded in the tongue epithelium. Prior to about 1981, many taste researchers regarded the tongue epithelium as virtually impermeable to most substances including small electrolytes. Taste transduction was assumed to be due to equilibrium adsorption of tastants to receptors on the taste cell membrane. More recent experiments show that, in the case of salt taste, the electrical events associated with transduction are due to ion flow across membranes rather than ion binding to a receptor. We wished to determine if standard assumptions about topology and membrane ion transport processes in high resistance (“tight”) epithelia apply to the tongue for a range of salt concentrations on the tongue surface. A model of the tongue epithelium was developed based on an earlier network model of ion transport in a kidney tight epithelium. The model has 4 membranes with series and parallel pathways and 3 transported ions. The model successfully simulates some aspects of both steady-state and transient transepithelial electrical measurements observed in vitro for a wide range (50–2000 mM) of NaCl concentrations. This is the concentration range of interest for gustation. The earlier kidney model had not been applied to hyperosmotic NaCl concentrations. The simulations indicate that common epithelial transport mechanisms can account for some phenomena important in taste transduction. They also indicate that the Na + channels in taste cells have different properties than those typical in other tight epithelia." @default.
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- W1999353649 title "The role of epithelial ion transport in taste transduction: A network thermodynamic model" @default.
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- W1999353649 doi "https://doi.org/10.1016/0895-7177(94)90192-9" @default.
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