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- W1999358152 abstract "In order to compare the morphine‐sparing effect, analgesic efficacy and tolerance of nefopam and propacetamol given at their highest recommended doses, 120 patients undergoing elective hepatic resection were randomly assigned to receive postoperative intravenous patient‐controlled analgesia with morphine alone, or in combination with nefopam (20 mg.4 h ‐1 ) or propacetamol (2 g.6 h ‐1 ). Compared with the control group (43 [7–92] mg), median [range] cumulative morphine consumption for 24 h after the study started was halved in the nefopam group (21 [3–78] mg, p <0.001) and 20% lower in the propacetamol group (35 [6–84] mg, p = 0.15). Analgesia was superior in the nefopam group despite the lower morphine consumption. Adverse effects were comparable in the three groups, except for significantly more nausea in the control group (39% vs. 17 and 26% in the nefopam and propacetamol groups, respectively) and more sweating in the nefopam group (17% vs. 0 and 3% in the control and propacetamol groups, respectively). Overall patient satisfaction was better (p < 0.001) in patients given nefopam (97%) than those receiving morphine alone (82%) or propacetamol (74%)." @default.
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- W1999358152 date "2001-06-01" @default.
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- W1999358152 title "Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection*" @default.
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- W1999358152 doi "https://doi.org/10.1046/j.1365-2044.2001.01980.x" @default.
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