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• W1999368051 endingPage "924" @default.
• W1999368051 startingPage "911" @default.
• W1999368051 abstract "The metabolic syndrome (syndrome X) is a cluster of risk factors and a common cause of cardiovascular disease in humans. Although the underlying mechanism for metabolic syndrome is still poorly understood, recent clinical data and studies with transgenic animals implicate elevated intracellular glucocorticoid tone in the etiology of metabolic syndrome. Development of selective inhibitors of 11β-hydroxysteroid dehydrogenase (11β-HSD)-1 and their use in rodent animal disease models encompassing several aspects of metabolic syndrome indicate the possibility of therapeutic intervention. This review will focus on recent advances in our understanding of the role of 11β-HSD1 in metabolic disorders and other disease processes." @default.
• W1999368051 created "2016-06-24" @default.
• W1999368051 creator A5084780906 @default.
• W1999368051 creator A5085573793 @default.
• W1999368051 date "2005-09-01" @default.
• W1999368051 modified "2023-09-25" @default.
• W1999368051 title "Inhibition of 11β-HSD1 as a novel treatment for the metabolic syndrome: do glucocorticoids play a role?" @default.
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