Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999386671> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1999386671 abstract "Most adverse cutaneous drug reactions (ACDR) are mediated by delayed hypersensitivity (dh) with lymphocyte recruitment and inflammatory cytokines release, including tumour necrosis factor alpha (TNFalpha). Polymorphisms in the TNFalpha gene, such as the infrequent allele TNF2, predispose to certain inflammatory entities and enhance TNFalpha production. The incidence of the TNF2 allele is increased in British patients with severe ACDR, suggesting TNFalpha as a major contributor in the pathogenesis of ACDR.We designed a prospective study to analyse the epidemiology of ACDR in a third-level Mexican hospital and explore the possibility of a relationship between the TNF2 allele and ACDR-dh.A prospective study during 9 months allowed recognition of 34 ACDR-dh patients. The study included 33 paired patients, and 44 healthy volunteers. All subjects were genotyped for TNF2 by PCR DNA amplification and NcoI restriction endonuclease digestion. Results Incidence of ACDR was 0.95%. The TNF2 allele was detected in 9.9% of the sample population with no significant differences between healthy controls, and patients with or without ACDR-dh. Only 3 of the 34 ACDR-dh subjects presented severe reactions, with 1 having the TNF2 allele. Comorbidity analysis showed significance only with autoimmune thyroid disease, consistent with reports on Chinese and Tunisian patients.ACDR incidence and TNF2/TNFA heterozygosity were lower in Mexican than in Caucasian patients. ACDR-dh patients showed no increased frequency in the TNF2 allele." @default.
- W1999386671 created "2016-06-24" @default.
- W1999386671 creator A5005343116 @default.
- W1999386671 creator A5022493823 @default.
- W1999386671 creator A5059252621 @default.
- W1999386671 date "2009-07-01" @default.
- W1999386671 modified "2023-10-16" @default.
- W1999386671 title "Incidence of adverse cutaneous drug reactions in a Mexican sample: an exploratory study on their association to tumour necrosis factor alpha TNF2 allele" @default.
- W1999386671 cites W1546747274 @default.
- W1999386671 cites W1996220604 @default.
- W1999386671 cites W1999464995 @default.
- W1999386671 cites W2001805749 @default.
- W1999386671 cites W2014048895 @default.
- W1999386671 cites W2017306702 @default.
- W1999386671 cites W2026786900 @default.
- W1999386671 cites W2047005985 @default.
- W1999386671 cites W2049377340 @default.
- W1999386671 cites W2052008987 @default.
- W1999386671 cites W2056382301 @default.
- W1999386671 cites W2061542205 @default.
- W1999386671 cites W2063146416 @default.
- W1999386671 cites W2087094124 @default.
- W1999386671 cites W2103213111 @default.
- W1999386671 cites W2103559160 @default.
- W1999386671 cites W2114748094 @default.
- W1999386671 cites W2149224515 @default.
- W1999386671 doi "https://doi.org/10.1111/j.1468-3083.2009.03173.x" @default.
- W1999386671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19309429" @default.
- W1999386671 hasPublicationYear "2009" @default.
- W1999386671 type Work @default.
- W1999386671 sameAs 1999386671 @default.
- W1999386671 citedByCount "6" @default.
- W1999386671 countsByYear W19993866712012 @default.
- W1999386671 countsByYear W19993866712014 @default.
- W1999386671 countsByYear W19993866712015 @default.
- W1999386671 crossrefType "journal-article" @default.
- W1999386671 hasAuthorship W1999386671A5005343116 @default.
- W1999386671 hasAuthorship W1999386671A5022493823 @default.
- W1999386671 hasAuthorship W1999386671A5059252621 @default.
- W1999386671 hasConcept C104317684 @default.
- W1999386671 hasConcept C180754005 @default.
- W1999386671 hasConcept C203014093 @default.
- W1999386671 hasConcept C2908647359 @default.
- W1999386671 hasConcept C37463918 @default.
- W1999386671 hasConcept C54355233 @default.
- W1999386671 hasConcept C71924100 @default.
- W1999386671 hasConcept C86803240 @default.
- W1999386671 hasConcept C99454951 @default.
- W1999386671 hasConceptScore W1999386671C104317684 @default.
- W1999386671 hasConceptScore W1999386671C180754005 @default.
- W1999386671 hasConceptScore W1999386671C203014093 @default.
- W1999386671 hasConceptScore W1999386671C2908647359 @default.
- W1999386671 hasConceptScore W1999386671C37463918 @default.
- W1999386671 hasConceptScore W1999386671C54355233 @default.
- W1999386671 hasConceptScore W1999386671C71924100 @default.
- W1999386671 hasConceptScore W1999386671C86803240 @default.
- W1999386671 hasConceptScore W1999386671C99454951 @default.
- W1999386671 hasLocation W19993866711 @default.
- W1999386671 hasLocation W19993866712 @default.
- W1999386671 hasOpenAccess W1999386671 @default.
- W1999386671 hasPrimaryLocation W19993866711 @default.
- W1999386671 hasRelatedWork W1560624496 @default.
- W1999386671 hasRelatedWork W1991060602 @default.
- W1999386671 hasRelatedWork W2009008398 @default.
- W1999386671 hasRelatedWork W2046088649 @default.
- W1999386671 hasRelatedWork W2091054858 @default.
- W1999386671 hasRelatedWork W2091842850 @default.
- W1999386671 hasRelatedWork W2147458577 @default.
- W1999386671 hasRelatedWork W2150765396 @default.
- W1999386671 hasRelatedWork W2166715959 @default.
- W1999386671 hasRelatedWork W2169157594 @default.
- W1999386671 hasRelatedWork W2278256566 @default.
- W1999386671 hasRelatedWork W2280440761 @default.
- W1999386671 hasRelatedWork W2346488766 @default.
- W1999386671 hasRelatedWork W2351617830 @default.
- W1999386671 hasRelatedWork W2369180996 @default.
- W1999386671 hasRelatedWork W2410292517 @default.
- W1999386671 hasRelatedWork W2428343936 @default.
- W1999386671 hasRelatedWork W2802993765 @default.
- W1999386671 hasRelatedWork W2974649950 @default.
- W1999386671 hasRelatedWork W63180488 @default.
- W1999386671 isParatext "false" @default.
- W1999386671 isRetracted "false" @default.
- W1999386671 magId "1999386671" @default.
- W1999386671 workType "article" @default.