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- W1999386908 abstract "Abstract Incubation of human erythrocytes with copper sulfate results in hemolysis. Progesterone enhances substantially the copper-induced hemolysis under conditions in which progesterone alone does not cause hemolysis. Addition of progesterone, after preincubation with copper sulfate, affects the induction period that occurs before hemolysis; increasing the time of preincubation decreases the induction period. In contrast, the length of time needed for detecting hemolysis is not affected by the length of the preincubation period with progesterone. The time period required for hemolysis to commence after copper sulfate is added, following a preincubation with progesterone, is similar to that time period which is observed when copper sulfate and progesterone are added together at the beginning of the incubation. Calcium chloride inhibits the copper-progesterone hemolysis. Copper sulfate alone causes the erythrocytes to have an increased osmotic fragility. The results suggest that progesterone initiates hemolysis by binding to sites exposed after copper ions cause alterations in the membrane." @default.
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- W1999386908 title "Enhancement of the copper-induced hemolysis by progesterone" @default.
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- W1999386908 doi "https://doi.org/10.1016/0022-4731(74)90112-5" @default.
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