Matches in SemOpenAlex for { <https://semopenalex.org/work/W1999398082> ?p ?o ?g. }
- W1999398082 endingPage "1584" @default.
- W1999398082 startingPage "1579" @default.
- W1999398082 abstract "Type-I ribosome-inactivating protein-trichosanthin (TCS) exhibits selective cytotoxicity toward different types of cells. It is believed that the cytotoxicity results from the inhibition of ribosomes to decrease protein synthesis , thereby indicating that there are specific mechanisms for TCS entry into target cells to reach the ribosomes. Low-density lipoprotein (LDL) receptor-related protein 1 (LRP1) is a large scavenger receptor that is responsible for the binding and endocytosis of diverse biological ligands on the cell surface. In this study, we demonstrated that 2 choriocarcinoma cell lines can significantly bind and internalize TCS. In contrast, Hela cell line displayed no obvious TCS binding and endocytosis. Furthermore LRP1 gene silencing in JAR and BeWo cell lines blocked TCS binding; TCS could also interact with LRP1.The results of our study established that LRP1 was a major receptor for phagocytosis of TCS in JAR and BeWo cell lines and might be the molecular basis of TCS abortificient and anti-choriocarcinoma activity." @default.
- W1999398082 created "2016-06-24" @default.
- W1999398082 creator A5032600357 @default.
- W1999398082 creator A5091120394 @default.
- W1999398082 date "2010-01-01" @default.
- W1999398082 modified "2023-09-24" @default.
- W1999398082 title "Low-density lipoprotein receptor-related protein 1 is an essential receptor for trichosanthin in 2 choriocarcinoma cell lines" @default.
- W1999398082 cites W1484985322 @default.
- W1999398082 cites W1522730050 @default.
- W1999398082 cites W1551287182 @default.
- W1999398082 cites W1569488450 @default.
- W1999398082 cites W1593508376 @default.
- W1999398082 cites W1967546408 @default.
- W1999398082 cites W1969300374 @default.
- W1999398082 cites W1970502611 @default.
- W1999398082 cites W1977311572 @default.
- W1999398082 cites W1978131045 @default.
- W1999398082 cites W1988193334 @default.
- W1999398082 cites W1999476309 @default.
- W1999398082 cites W2005111415 @default.
- W1999398082 cites W2012218342 @default.
- W1999398082 cites W2013376333 @default.
- W1999398082 cites W2018873526 @default.
- W1999398082 cites W2033329434 @default.
- W1999398082 cites W2035026318 @default.
- W1999398082 cites W2054412300 @default.
- W1999398082 cites W2063272768 @default.
- W1999398082 cites W2080288643 @default.
- W1999398082 cites W2085577847 @default.
- W1999398082 cites W2085648931 @default.
- W1999398082 cites W2087334661 @default.
- W1999398082 cites W2097237259 @default.
- W1999398082 cites W2127256767 @default.
- W1999398082 cites W2130630969 @default.
- W1999398082 cites W2147987239 @default.
- W1999398082 cites W2162175812 @default.
- W1999398082 doi "https://doi.org/10.1016/j.bbrc.2009.12.006" @default.
- W1999398082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19968964" @default.
- W1999398082 hasPublicationYear "2010" @default.
- W1999398082 type Work @default.
- W1999398082 sameAs 1999398082 @default.
- W1999398082 citedByCount "23" @default.
- W1999398082 countsByYear W19993980822012 @default.
- W1999398082 countsByYear W19993980822013 @default.
- W1999398082 countsByYear W19993980822014 @default.
- W1999398082 countsByYear W19993980822015 @default.
- W1999398082 countsByYear W19993980822016 @default.
- W1999398082 countsByYear W19993980822017 @default.
- W1999398082 countsByYear W19993980822018 @default.
- W1999398082 countsByYear W19993980822019 @default.
- W1999398082 countsByYear W19993980822020 @default.
- W1999398082 countsByYear W19993980822021 @default.
- W1999398082 countsByYear W19993980822022 @default.
- W1999398082 crossrefType "journal-article" @default.
- W1999398082 hasAuthorship W1999398082A5032600357 @default.
- W1999398082 hasAuthorship W1999398082A5091120394 @default.
- W1999398082 hasConcept C109316439 @default.
- W1999398082 hasConcept C115085202 @default.
- W1999398082 hasConcept C139647698 @default.
- W1999398082 hasConcept C153911025 @default.
- W1999398082 hasConcept C170493617 @default.
- W1999398082 hasConcept C185592680 @default.
- W1999398082 hasConcept C202751555 @default.
- W1999398082 hasConcept C2778163477 @default.
- W1999398082 hasConcept C2780072125 @default.
- W1999398082 hasConcept C2781260279 @default.
- W1999398082 hasConcept C28005876 @default.
- W1999398082 hasConcept C43554185 @default.
- W1999398082 hasConcept C54355233 @default.
- W1999398082 hasConcept C55493867 @default.
- W1999398082 hasConcept C81885089 @default.
- W1999398082 hasConcept C86803240 @default.
- W1999398082 hasConcept C95444343 @default.
- W1999398082 hasConceptScore W1999398082C109316439 @default.
- W1999398082 hasConceptScore W1999398082C115085202 @default.
- W1999398082 hasConceptScore W1999398082C139647698 @default.
- W1999398082 hasConceptScore W1999398082C153911025 @default.
- W1999398082 hasConceptScore W1999398082C170493617 @default.
- W1999398082 hasConceptScore W1999398082C185592680 @default.
- W1999398082 hasConceptScore W1999398082C202751555 @default.
- W1999398082 hasConceptScore W1999398082C2778163477 @default.
- W1999398082 hasConceptScore W1999398082C2780072125 @default.
- W1999398082 hasConceptScore W1999398082C2781260279 @default.
- W1999398082 hasConceptScore W1999398082C28005876 @default.
- W1999398082 hasConceptScore W1999398082C43554185 @default.
- W1999398082 hasConceptScore W1999398082C54355233 @default.
- W1999398082 hasConceptScore W1999398082C55493867 @default.
- W1999398082 hasConceptScore W1999398082C81885089 @default.
- W1999398082 hasConceptScore W1999398082C86803240 @default.
- W1999398082 hasConceptScore W1999398082C95444343 @default.
- W1999398082 hasFunder F4320321133 @default.
- W1999398082 hasIssue "4" @default.
- W1999398082 hasLocation W19993980821 @default.
- W1999398082 hasLocation W19993980822 @default.
- W1999398082 hasOpenAccess W1999398082 @default.
- W1999398082 hasPrimaryLocation W19993980821 @default.
- W1999398082 hasRelatedWork W1974824219 @default.
- W1999398082 hasRelatedWork W1999398082 @default.